Mitochondria-containing extracellular vesicles from mouse vs. human brain endothelial cells for ischemic stroke therapy.

Autor: Dave KM; Graduate School of Pharmaceutical Sciences, Duquesne University, Pittsburgh, PA, United States of America., Venna VR; Department of Neurology, McGovern Medical School, University of Texas Health Science Center, Houston, TX, United States of America., Rao KS; Pittsburgh Heart Lung Blood Vascular Institute, University of Pittsburgh Medical School, Pittsburgh, PA, United States of America., Stolz DB; Center for Biologic Imaging, University of Pittsburgh Medical School, Pittsburgh, PA, United States of America., Brady B; Human Biology, South Dakota State University, Brookings, SD, United States of America., Quaicoe VA; Department of Neurology, McGovern Medical School, University of Texas Health Science Center, Houston, TX, United States of America., Maniskas ME; Department of Neurology, McGovern Medical School, University of Texas Health Science Center, Houston, TX, United States of America., Hildebrand EE; Graduate School of Pharmaceutical Sciences, Duquesne University, Pittsburgh, PA, United States of America; Department of Psychology, Westminster College, New Wilmington, PA, United States of America., Green D; Graduate School of Pharmaceutical Sciences, Duquesne University, Pittsburgh, PA, United States of America., Chen M; Department of Biomedical Engineering, Carnegie Mellon University, Pittsburgh, PA, United States of America., Milosevic J; Department of Biomedical Engineering, Carnegie Mellon University, Pittsburgh, PA, United States of America; Captis Diagnostics Inc, Pittsburgh, PA, United States of America., Zheng SY; Department of Biomedical Engineering, Carnegie Mellon University, Pittsburgh, PA, United States of America., Shiva SS; Pittsburgh Heart Lung Blood Vascular Institute, University of Pittsburgh Medical School, Pittsburgh, PA, United States of America; Department of Pharmacology and Chemical Biology, University of Pittsburgh Medical School, Pittsburgh, PA, United States of America., McCullough LD; Department of Neurology, McGovern Medical School, University of Texas Health Science Center, Houston, TX, United States of America., S Manickam D; Graduate School of Pharmaceutical Sciences, Duquesne University, Pittsburgh, PA, United States of America. Electronic address: soundaramanickd@duq.edu.

Publikováno v: Journal of controlled release : official journal of the Controlled Release Society [J Control Release] 2024 Sep; Vol. 373, pp. 803-822. Date of Electronic Publication: 2024 Aug 02.

The AKT2/SIRT5/TFEB pathway as a potential therapeutic target in non-neovascular AMD.

Autor: Ghosh S; Department of Ophthalmology, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA., Sharma R; Ocular and Stem Cell Translational Research Section, National Eye Institute, National Institutes of Health, Bethesda, MD, USA., Bammidi S; Department of Ophthalmology, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA., Koontz V; Department of Ophthalmology, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA., Nemani M; Department of Ophthalmology, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA., Yazdankhah M; Department of Ophthalmology, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA., Kedziora KM; Department of Cell Biology, Center for Biologic Imaging, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA., Stolz DB; Department of Cell Biology, Center for Biologic Imaging, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA., Wallace CT; Department of Cell Biology, Center for Biologic Imaging, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA., Yu-Wei C; Aging Institute, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA., Franks J; Department of Cell Biology, Center for Biologic Imaging, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA., Bose D; Ocular and Stem Cell Translational Research Section, National Eye Institute, National Institutes of Health, Bethesda, MD, USA., Shang P; Doheny Eye Institute, Pasadena, CA, USA., Ambrosino HM; Doheny Eye Institute, Pasadena, CA, USA., Dutton JR; Stem Cell Institute, University of Minnesota, Minneapolis, MN, USA., Geng Z; Stem Cell Institute, University of Minnesota, Minneapolis, MN, USA., Montford J; Ocular and Stem Cell Translational Research Section, National Eye Institute, National Institutes of Health, Bethesda, MD, USA., Ryu J; Ocular and Stem Cell Translational Research Section, National Eye Institute, National Institutes of Health, Bethesda, MD, USA., Rajasundaram D; Department of Pediatrics, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA., Hose S; Department of Ophthalmology, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA., Sahel JA; Department of Ophthalmology, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA.; Institut De La Vision, INSERM, CNRS, Sorbonne Université, Paris, France., Puertollano R; Cell Biology and Physiology Center, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD, USA., Finkel T; Aging Institute, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA., Zigler JS Jr; Wilmer Eye Institute, The Johns Hopkins University School of Medicine, Baltimore, MD, USA., Sergeev Y; Protein Biochemistry & Molecular Modeling Group, National Eye Institute, National Institutes of Health, Bethesda, MD, USA., Watkins SC; Department of Cell Biology, Center for Biologic Imaging, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA., Goetzman ES; Department of Pediatrics, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA., Ferrington DA; Doheny Eye Institute, Pasadena, CA, USA.; Department of Ophthalmology, University of California Los Angeles, Los Angeles, CA, USA., Flores-Bellver M; Department of Ophthalmology, University of Colorado Anschutz Medical Campus, Aurora, Colorado, USA., Kaarniranta K; Department of Ophthalmology, University of Eastern Finland and Kuopio University Hospital, Kuopio, Finland.; Department of Molecular Genetics, University of Lodz, Lodz, Poland., Sodhi A; Wilmer Eye Institute, The Johns Hopkins University School of Medicine, Baltimore, MD, USA., Bharti K; Ocular and Stem Cell Translational Research Section, National Eye Institute, National Institutes of Health, Bethesda, MD, USA. kapil.bharti@nih.gov., Handa JT; Wilmer Eye Institute, The Johns Hopkins University School of Medicine, Baltimore, MD, USA. jthanda@jhmi.edu., Sinha D; Department of Ophthalmology, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA. Debasish@pitt.edu.; Wilmer Eye Institute, The Johns Hopkins University School of Medicine, Baltimore, MD, USA. Debasish@pitt.edu.

Publikováno v: Nature communications [Nat Commun] 2024 Jul 21; Vol. 15 (1), pp. 6150. Date of Electronic Publication: 2024 Jul 21.

A genetically inducible endothelial niche enables vascularization of human kidney organoids with multilineage maturation and emergence of renin expressing cells.

Autor: Maggiore JC; Department of Cell Biology, School of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania, USA; Center for Integrative Organ Systems, University of Pittsburgh, Pittsburgh, Pennsylvania, USA., LeGraw R; Department of Pathology, Division of Experimental Pathology, School of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania, USA; Pittsburgh Liver Research Center, University of Pittsburgh, Pittsburgh, Pennsylvania, USA., Przepiorski A; Department of Cell Biology, School of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania, USA., Velazquez J; Department of Pathology, Division of Experimental Pathology, School of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania, USA; Pittsburgh Liver Research Center, University of Pittsburgh, Pittsburgh, Pennsylvania, USA., Chaney C; Department of Molecular Biology, University of Texas Southwestern Medical Center, Dallas, Texas, USA; Hamon Center for Regenerative Science and Medicine, University of Texas Southwestern Medical Center, Dallas, Texas, USA; Department of Internal Medicine, Division of Nephrology, University of Texas Southwestern Medical Center, Dallas, Texas, USA., Vanichapol T; Department of Molecular Medicine and Pathology, University of Auckland, Auckland, New Zealand., Streeter E; Department of Cell Biology, School of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania, USA; Center for Integrative Organ Systems, University of Pittsburgh, Pittsburgh, Pennsylvania, USA., Almuallim Z; Department of Cell Biology, School of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania, USA; Center for Integrative Organ Systems, University of Pittsburgh, Pittsburgh, Pennsylvania, USA., Oda A; Department of Pediatrics, School of Medicine, University of Pittsburgh, Pittsburgh Pennsylvania, USA., Chiba T; Department of Pediatrics, School of Medicine, University of Pittsburgh, Pittsburgh Pennsylvania, USA., Silva-Barbosa A; Department of Pediatrics, School of Medicine, University of Pittsburgh, Pittsburgh Pennsylvania, USA., Franks J; Center for Biologic Imaging, University of Pittsburgh, Pittsburgh, Pennsylvania, USA., Hislop J; Pittsburgh Liver Research Center, University of Pittsburgh, Pittsburgh, Pennsylvania, USA; Department of Bioengineering, Swanson School of Engineering, University of Pittsburgh, Pittsburgh, Pennsylvania, USA., Hill A; Department of Pathology, Division of Experimental Pathology, School of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania, USA; Pittsburgh Liver Research Center, University of Pittsburgh, Pittsburgh, Pennsylvania, USA., Wu H; Division of Nephrology, Department of Medicine, School of Medicine, Washington University in St. Louis, St. Louis, Missouri, USA., Pfister K; Department of Pediatrics, School of Medicine, University of Pittsburgh, Pittsburgh Pennsylvania, USA., Howden SE; Murdoch Children's Research Institute, Melbourne, Victoria, Australia., Watkins SC; Center for Biologic Imaging, University of Pittsburgh, Pittsburgh, Pennsylvania, USA., Little MH; Murdoch Children's Research Institute, Melbourne, Victoria, Australia; Department of Anatomy and Neuroscience, The University of Melbourne, Melbourne, Victoria, Australia; Department of Paediatrics, The University of Melbourne, Melbourne, Victoria, Australia., Humphreys BD; Division of Nephrology, Department of Medicine, School of Medicine, Washington University in St. Louis, St. Louis, Missouri, USA; Department of Developmental Biology, School of Medicine, Washington University in St. Louis, St. Louis, Missouri, USA., Kiani S; Department of Pathology, Division of Experimental Pathology, School of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania, USA; Pittsburgh Liver Research Center, University of Pittsburgh, Pittsburgh, Pennsylvania, USA; Center for Biologic Imaging, University of Pittsburgh, Pittsburgh, Pennsylvania, USA; McGowan Institute for Regenerative Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania, USA., Watson A; Center for Biologic Imaging, University of Pittsburgh, Pittsburgh, Pennsylvania, USA., Stolz DB; Center for Biologic Imaging, University of Pittsburgh, Pittsburgh, Pennsylvania, USA., Davidson AJ; Department of Molecular Medicine and Pathology, University of Auckland, Auckland, New Zealand., Carroll T; Department of Molecular Biology, University of Texas Southwestern Medical Center, Dallas, Texas, USA; Hamon Center for Regenerative Science and Medicine, University of Texas Southwestern Medical Center, Dallas, Texas, USA; Department of Internal Medicine, Division of Nephrology, University of Texas Southwestern Medical Center, Dallas, Texas, USA., Cleaver O; Department of Molecular Biology, University of Texas Southwestern Medical Center, Dallas, Texas, USA., Sims-Lucas S; Department of Pediatrics, School of Medicine, University of Pittsburgh, Pittsburgh Pennsylvania, USA., Ebrahimkhani MR; Department of Pathology, Division of Experimental Pathology, School of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania, USA; Pittsburgh Liver Research Center, University of Pittsburgh, Pittsburgh, Pennsylvania, USA; Department of Molecular Biology, University of Texas Southwestern Medical Center, Dallas, Texas, USA; Department of Bioengineering, Swanson School of Engineering, University of Pittsburgh, Pittsburgh, Pennsylvania, USA. Electronic address: mo.ebr@pitt.edu., Hukriede NA; Department of Cell Biology, School of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania, USA; Center for Integrative Organ Systems, University of Pittsburgh, Pittsburgh, Pennsylvania, USA. Electronic address: hukriede@pitt.edu.

Publikováno v: Kidney international [Kidney Int] 2024 Jun 18. Date of Electronic Publication: 2024 Jun 18.

Genetic regulation and targeted reversal of lysosomal dysfunction and inflammatory sterol metabolism in pulmonary arterial hypertension.

Autor: Harvey LD, Alotaibi M, Kim HJ, Tai YY, Tang Y, Sun W, El Khoury W, Woodcock CC, Aaraj YA, St Croix CM, Stolz DB, Lee J, Cheng MH, Schwantes-An TH, Desai AA, Pauciulo MW, Nichols WC, Webb A, Lafyatis R, Nouraie M, Wu H, McDonald JG, Chauvet C, Cheng S, Bahar I, Bertero T, Benza RL, Jain M, Chan SY

Publikováno v: BioRxiv : the preprint server for biology [bioRxiv] 2024 Mar 01. Date of Electronic Publication: 2024 Mar 01.

Hepatocyte β-catenin loss is compensated by Insulin-mTORC1 activation to promote liver regeneration.

Autor: Hu S; School of Medicine , Tsinghua University , Beijing , China.; Division of Experimental Pathology, Department of Pathology , University of Pittsburgh School of Medicine , Pittsburgh , Pennsylvania , USA., Cao C; Division of Experimental Pathology, Department of Pathology , University of Pittsburgh School of Medicine , Pittsburgh , Pennsylvania , USA., Poddar M; Division of Experimental Pathology, Department of Pathology , University of Pittsburgh School of Medicine , Pittsburgh , Pennsylvania , USA., Delgado E; Division of Experimental Pathology, Department of Pathology , University of Pittsburgh School of Medicine , Pittsburgh , Pennsylvania , USA.; Pittsburgh Liver Research Center, University of Pittsburgh Medical Center and University of Pittsburgh , Pittsburgh , Pennsylvania , USA., Singh S; Division of Experimental Pathology, Department of Pathology , University of Pittsburgh School of Medicine , Pittsburgh , Pennsylvania , USA., Singh-Varma A; Division of Experimental Pathology, Department of Pathology , University of Pittsburgh School of Medicine , Pittsburgh , Pennsylvania , USA., Stolz DB; Center for Biologic Imaging, and Department of Cell Biology , University of Pittsburgh , Pittsburgh , Pennsylvania , USA., Bell A; Division of Experimental Pathology, Department of Pathology , University of Pittsburgh School of Medicine , Pittsburgh , Pennsylvania , USA.; Pittsburgh Liver Research Center, University of Pittsburgh Medical Center and University of Pittsburgh , Pittsburgh , Pennsylvania , USA., Monga SP; Division of Experimental Pathology, Department of Pathology , University of Pittsburgh School of Medicine , Pittsburgh , Pennsylvania , USA.; Pittsburgh Liver Research Center, University of Pittsburgh Medical Center and University of Pittsburgh , Pittsburgh , Pennsylvania , USA.; Division of Gastroenterology, Hepatology and Nutrition, Department of Medicine , University of Pittsburgh School of Medicine , Pittsburgh , Pennsylvania , USA.

Publikováno v: Hepatology (Baltimore, Md.) [Hepatology] 2023 May 01; Vol. 77 (5), pp. 1593-1611. Date of Electronic Publication: 2023 Apr 17.