Identification of proteins and cellular pathways targeted by 2-nitroimidazole hypoxic cytotoxins

Autor: Rashed, Faisal Bin, Stoica, Alexandru Cezar, MacDonald, Dawn, El-Saidi, Hassan, Ricardo, Carolynne, Bhatt, Bhumi, Moore, Jack, Diaz-Dussan, Diana, Ramamonjisoa, Nirilanto, Mowery, Yvonne, Damaraju, Sambasivarao, Fahlman, Richard, Kumar, Piyush, Weinfeld, Michael

Publikováno v: In Redox Biology May 2021 41

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Cellular mechanism of action of 2-nitroimidazoles as hypoxia-selective therapeutic agents.

Autor: Rashed FB; Department of Oncology, University of Alberta, Edmonton, Alberta, AB T6G 2R3, Canada., Diaz-Dussan D; Department of Chemical & Materials Engineering, University of Alberta, Edmonton, Alberta, AB T6G 2R3, Canada., Mashayekhi F; Department of Oncology, University of Alberta, Edmonton, Alberta, AB T6G 2R3, Canada., Macdonald D; Department of Oncology, University of Alberta, Edmonton, Alberta, AB T6G 2R3, Canada., Nation PN; Department of Laboratory Medicine & Pathology, University of Alberta, Edmonton, Alberta, AB T6G 2R3, Canada., Yang XH; Department of Oncology, University of Alberta, Edmonton, Alberta, AB T6G 2R3, Canada., Sokhi S; Department of Oncology, University of Alberta, Edmonton, Alberta, AB T6G 2R3, Canada., Stoica AC; Department of Oncology, University of Alberta, Edmonton, Alberta, AB T6G 2R3, Canada., El-Saidi H; Department of Oncology, University of Alberta, Edmonton, Alberta, AB T6G 2R3, Canada; Department of Pharmaceutical Chemistry, Faculty of Pharmacy, University of Alexandria, El Sultan Hussein St. Azarita, Alexandria, Egypt., Ricardo C; Department of Oncology, University of Alberta, Edmonton, Alberta, AB T6G 2R3, Canada., Narain R; Department of Chemical & Materials Engineering, University of Alberta, Edmonton, Alberta, AB T6G 2R3, Canada., Ismail IH; Department of Oncology, University of Alberta, Edmonton, Alberta, AB T6G 2R3, Canada; Biophysics Department, Faculty of Science, Cairo University, Cairo, Egypt., Wiebe LI; Department of Oncology, University of Alberta, Edmonton, Alberta, AB T6G 2R3, Canada., Kumar P; Department of Oncology, University of Alberta, Edmonton, Alberta, AB T6G 2R3, Canada. Electronic address: pkumar@ualberta.ca., Weinfeld M; Department of Oncology, University of Alberta, Edmonton, Alberta, AB T6G 2R3, Canada. Electronic address: mweinfel@ualberta.ca.

Publikováno v: Redox biology [Redox Biol] 2022 Jun; Vol. 52, pp. 102300. Date of Electronic Publication: 2022 Mar 21.