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An anti-ACVR1 antibody exacerbates heterotopic ossification by fibro-adipogenic progenitors in fibrodysplasia ossificans progressiva mice.

Autor: Lees-Shepard JB; Department of Molecular & Cell Biology, University of Connecticut Stem Cell Institute, University of Connecticut, Storrs, Connecticut, USA., Stoessel SJ; Department of Molecular & Cell Biology, University of Connecticut Stem Cell Institute, University of Connecticut, Storrs, Connecticut, USA., Chandler JT; Alexion Pharmaceuticals Inc., New Haven, Connecticut, USA., Bouchard K; Alexion Pharmaceuticals Inc., New Haven, Connecticut, USA., Bento P; Alexion Pharmaceuticals Inc., New Haven, Connecticut, USA., Apuzzo LN; Department of Molecular & Cell Biology, University of Connecticut Stem Cell Institute, University of Connecticut, Storrs, Connecticut, USA., Devarakonda PM; Department of Molecular & Cell Biology, University of Connecticut Stem Cell Institute, University of Connecticut, Storrs, Connecticut, USA., Hunter JW; Alexion Pharmaceuticals Inc., New Haven, Connecticut, USA., Goldhamer DJ; Department of Molecular & Cell Biology, University of Connecticut Stem Cell Institute, University of Connecticut, Storrs, Connecticut, USA.

Publikováno v: The Journal of clinical investigation [J Clin Invest] 2022 Jun 15; Vol. 132 (12).

Activin-dependent signaling in fibro/adipogenic progenitors causes fibrodysplasia ossificans progressiva.

Autor: Lees-Shepard JB; Department of Molecular and Cell Biology, University of Connecticut Stem Cell Institute, University of Connecticut, Storrs, CT, 06269, USA., Yamamoto M; Department of Molecular and Cell Biology, University of Connecticut Stem Cell Institute, University of Connecticut, Storrs, CT, 06269, USA., Biswas AA; Department of Molecular and Cell Biology, University of Connecticut Stem Cell Institute, University of Connecticut, Storrs, CT, 06269, USA., Stoessel SJ; Department of Molecular and Cell Biology, University of Connecticut Stem Cell Institute, University of Connecticut, Storrs, CT, 06269, USA., Nicholas SE; Department of Molecular and Cell Biology, University of Connecticut Stem Cell Institute, University of Connecticut, Storrs, CT, 06269, USA., Cogswell CA; Department of Molecular and Cell Biology, University of Connecticut Stem Cell Institute, University of Connecticut, Storrs, CT, 06269, USA., Devarakonda PM; Department of Molecular and Cell Biology, University of Connecticut Stem Cell Institute, University of Connecticut, Storrs, CT, 06269, USA., Schneider MJ Jr; Department of Molecular and Cell Biology, University of Connecticut Stem Cell Institute, University of Connecticut, Storrs, CT, 06269, USA., Cummins SM; Department of Molecular and Cell Biology, University of Connecticut Stem Cell Institute, University of Connecticut, Storrs, CT, 06269, USA., Legendre NP; Department of Molecular and Cell Biology, University of Connecticut Stem Cell Institute, University of Connecticut, Storrs, CT, 06269, USA., Yamamoto S; Department of Molecular and Cell Biology, University of Connecticut Stem Cell Institute, University of Connecticut, Storrs, CT, 06269, USA., Kaartinen V; Department of Biological and Materials Sciences, School of Dentistry, University of Michigan, Ann Arbor, MI, 48109, USA., Hunter JW; Alexion Pharmaceuticals, 100 College St, New Haven, CT, 06510, USA., Goldhamer DJ; Department of Molecular and Cell Biology, University of Connecticut Stem Cell Institute, University of Connecticut, Storrs, CT, 06269, USA. david.goldhamer@uconn.edu.

Publikováno v: Nature communications [Nat Commun] 2018 Feb 02; Vol. 9 (1), pp. 471. Date of Electronic Publication: 2018 Feb 02.