Clinical pharmacology and tolerability of REC‐994, a redox‐cycling nitroxide compound, in randomized phase 1 dose‐finding studies.

Autor: Alfa, Ron¹ (AUTHOR), Considine, Timothy¹ (AUTHOR), Virani, Shafique¹ (AUTHOR), Pfeiffer, Matt¹ (AUTHOR), Donato, Anthony² (AUTHOR), Dickerson, Daniel³ (AUTHOR), Shuster, Diana¹ (AUTHOR), Ellis, Joel¹ (AUTHOR), Rushton, Kristen¹ (AUTHOR), Wei, Helen¹ (AUTHOR), Gibson, Christopher¹ (AUTHOR) christopher.gibson@recursionpharma.com

Publikováno v: Pharmacology Research & Perspectives. Jun2024, Vol. 12 Issue 3, p1-12. 12p.

Transcriptomic signatures of individual cell types in cerebral cavernous malformation.

Autor: Li, Ying^1,2 (AUTHOR), Girard, Romuald² (AUTHOR), Srinath, Abhinav² (AUTHOR), Cruz, Diana Vera³ (AUTHOR), Ciszewski, Cezary⁴ (AUTHOR), Chen, Chang³ (AUTHOR), Lightle, Rhonda² (AUTHOR), Romanos, Sharbel² (AUTHOR), Sone, Je Yeong² (AUTHOR), Moore, Thomas² (AUTHOR), DeBiasse, Dorothy² (AUTHOR), Stadnik, Agnieszka² (AUTHOR), Lee, Justine J.² (AUTHOR), Shenkar, Robert² (AUTHOR), Koskimäki, Janne^5,6 (AUTHOR), Lopez-Ramirez, Miguel A.^7,8 (AUTHOR), Marchuk, Douglas A.⁹ (AUTHOR), Ginsberg, Mark H.⁷ (AUTHOR), Kahn, Mark L.¹⁰ (AUTHOR), Shi, Changbin¹ (AUTHOR)

Publikováno v: Cell Communication & Signaling. 1/9/2024, Vol. 22 Issue 1, p1-16. 16p.

Tento výsledek nelze pro nepřihlášené uživatele zobrazit.
K zobrazení výsledku je třeba se přihlásit.

Exceptional aggressiveness of cerebral cavernous malformation disease associated with PDCD10 mutations.

Autor: Shenkar R; Neurovascular Surgery Program, Section of Neurosurgery, The University of Chicago Medicine, Chicago, IL 60637, USA., Shi C; Neurovascular Surgery Program, Section of Neurosurgery, The University of Chicago Medicine, Chicago, IL 60637, USA., Rebeiz T; Department of Neurology, The University of Chicago Medicine, Chicago, IL 60637, USA., Stockton RA; Department of Pediatrics, University of California at Los Angeles, Torrance, CA 90502, USA., McDonald DA; Department of Molecular Genetics and Microbiology, Duke University, Durham, NC 27710, USA.; Center for Science, Math and Technology Education, North Carolina Central University, Durham, NC 27707, USA., Mikati AG; Neurovascular Surgery Program, Section of Neurosurgery, The University of Chicago Medicine, Chicago, IL 60637, USA., Zhang L; Neurovascular Surgery Program, Section of Neurosurgery, The University of Chicago Medicine, Chicago, IL 60637, USA., Austin C; Neurovascular Surgery Program, Section of Neurosurgery, The University of Chicago Medicine, Chicago, IL 60637, USA., Akers AL; Angioma Alliance, Norfolk, VA 23510, USA., Gallione CJ; Department of Molecular Genetics and Microbiology, Duke University, Durham, NC 27710, USA., Rorrer A; Department of Molecular Genetics and Microbiology, Duke University, Durham, NC 27710, USA., Gunel M; Departments of Neurosurgery and Neurobiology, Yale University, New Haven, CT 06520, USA., Min W; Department of Pathology, Yale University, New Haven, CT 06520, USA., De Souza JM; Department of Neurosurgery, School of Medicine, Federal University of Rio De Janeiro, Rio de Janeiro, Brazil., Lee C; Angioma Alliance, Norfolk, VA 23510, USA., Marchuk DA; Department of Molecular Genetics and Microbiology, Duke University, Durham, NC 27710, USA., Awad IA; Neurovascular Surgery Program, Section of Neurosurgery, The University of Chicago Medicine, Chicago, IL 60637, USA.; Department of Neurology, The University of Chicago Medicine, Chicago, IL 60637, USA.

Publikováno v: Genetics in medicine : official journal of the American College of Medical Genetics [Genet Med] 2015 Mar; Vol. 17 (3), pp. 188-196. Date of Electronic Publication: 2014 Aug 14.

Force-mediated recruitment and reprogramming of healthy endothelial cells drive vascular lesion growth.

Autor: Shapeti, Apeksha, Barrasa-Fano, Jorge, Abdel Fattah, Abdel Rahman, de Jong, Janne, Sanz-Herrera, José Antonio, Pezet, Mylène, Assou, Said, de Vet, Emilie, Elahi, Seyed Ali, Ranga, Adrian, Faurobert, Eva, Van Oosterwyck, Hans

Publikováno v: Nature Communications; 10/6/2024, Vol. 15 Issue 1, p1-16, 16p