Genome-wide karyomapping accurately identifies the inheritance of single-gene defects in human preimplantation embryos in vitro.

Autor: Natesan SA; Illumina, Cambridge, UK., Bladon AJ; Illumina, Cambridge, UK., Coskun S; Department of Pathology and Laboratory Medicine, King Faisal Specialist Hospital and Research Center, Riyadh, Saudi Arabia., Qubbaj W; Department of Pathology and Laboratory Medicine, King Faisal Specialist Hospital and Research Center, Riyadh, Saudi Arabia., Prates R; Reprogenetics, Livingston, New Jersey, USA., Munne S; Reprogenetics, Livingston, New Jersey, USA., Coonen E; 1] Centre for Reproductive Medicine, Department of Obstetrics and Gynaecology, Maastricht University Medical Centre, Maastricht, The Netherlands [2] GROW, School for Oncology and Developmental Biology, University of Maastricht, Maastricht, The Netherlands., Dreesen JC; 1] GROW, School for Oncology and Developmental Biology, University of Maastricht, Maastricht, The Netherlands [2] Department of Clinical Genetics, Maastricht University Medical Center, Maastricht, The Netherlands., Stevens SJ; 1] GROW, School for Oncology and Developmental Biology, University of Maastricht, Maastricht, The Netherlands [2] Department of Clinical Genetics, Maastricht University Medical Center, Maastricht, The Netherlands., Paulussen AD; 1] GROW, School for Oncology and Developmental Biology, University of Maastricht, Maastricht, The Netherlands [2] Department of Clinical Genetics, Maastricht University Medical Center, Maastricht, The Netherlands., Stock-Myer SE; Preimplantation Genetics, Melbourne IVF, East Melbourne, Victoria, Australia., Wilton LJ; Preimplantation Genetics, Melbourne IVF, East Melbourne, Victoria, Australia., Jaroudi S; Reprogenetics UK, Institute of Reproductive Sciences, Oxford, UK., Wells D; Reprogenetics UK, Institute of Reproductive Sciences, Oxford, UK., Brown AP; Illumina, Cambridge, UK., Handyside AH; 1] Illumina, Cambridge, UK [2] The Bridge Centre, London, UK.

Publikováno v: Genetics in medicine : official journal of the American College of Medical Genetics [Genet Med] 2014 Nov; Vol. 16 (11), pp. 838-45. Date of Electronic Publication: 2014 May 08.