Zobrazeno 1 - 10 of 12 pro vyhledávání: '"Stjepko Cermak"'
1
Akademický článek
BACE1-cleavage of Sez6 and Sez6L is elevated in Niemann-Pick type C disease mouse brains.
Autor: Mirsada Causevic, Kristina Dominko, Martina Malnar, Lea Vidatic, Stjepko Cermak, Martina Pigoni, Peer-Hendrik Kuhn, Alessio Colombo, Daniel Havas, Stefanie Flunkert, Jessica McDonald, Jenny M Gunnersen, Birgit Hutter-Paier, Sabina Tahirovic, Manfred Windisch, Dimitri Krainc, Stefan F Lichtenthaler, Silva Hecimovic
Publikováno v: PLoS ONE, Vol 13, Iss 7, p e0200344 (2018)
It is intriguing that a rare, inherited lysosomal storage disorder Niemann-Pick type C (NPC) shares similarities with Alzheimer's disease (AD). We have previously reported an enhanced processing of β-amyloid precursor protein (APP) by β-secretase (
Externí odkaz: https://doaj.org/article/1789a778f74f4473b3cee534b11a03e1
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2
Akademický článek
Loss of Cathepsin B and L Leads to Lysosomal Dysfunction, NPC-Like Cholesterol Sequestration and Accumulation of the Key Alzheimer's Proteins.
Autor: Stjepko Cermak, Marko Kosicek, Aleksandra Mladenovic-Djordjevic, Kosara Smiljanic, Selma Kanazir, Silva Hecimovic
Publikováno v: PLoS ONE, Vol 11, Iss 11, p e0167428 (2016)
Proper function of lysosomes is particularly important in neurons, as they cannot dilute accumulated toxic molecules and aggregates by cell division. Thus, impairment of lysosomal function plays an important role in neuronal degeneration and in the p
Externí odkaz: https://doaj.org/article/5bb369c424eb4e27bb3ac841b1235402
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3
BACE1-cleavage of Sez6 and Sez6L is elevated in Niemann-Pick type C disease mouse brains
Autor: Kristina Dominko, Birgit Hutter-Paier, Stefan F. Lichtenthaler, Stjepko Cermak, Peer-Hendrik Kuhn, Dimitri Krainc, Martina Pigoni, Daniel Havas, Jessica McDonald, Mirsada Causevic, Alessio Colombo, Silva Hećimović, Manfred Windisch, Sabina Tahirovic, Stefanie Flunkert, Lea Vidatic, Martina Malnar, Jenny M. Gunnersen
Publikováno v: PLoS ONE, Vol 13, Iss 7, p e0200344 (2018)
PLoS One
PLOS ONE 13(7), e0200344 (2018). doi:10.1371/journal.pone.0200344
PLoS ONE
It is intriguing that a rare, inherited lysosomal storage disorder Niemann-Pick type C (NPC) shares similarities with Alzheimer’s disease (AD). We have previously reported an enhanced processing of β-amyloid precursor protein (APP) by β-secretase
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ca2df86dd999ca75b47b30c346042316
http://europepmc.org/articles/PMC6034874?pdf=render
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4
Synthesis and Preliminary Evaluation of a 2-Oxoquinoline Carboxylic Acid Derivative for PET Imaging the Cannabinoid Type 2 Receptor
Autor: Linjing Mu, Roger Slavik, Roger Schibli, Markus Weber, Kasim Popaj, Stjepko Cermak, Stefanie-Dorothea Krämer, Adrienne Müller, Simon M. Ametamey
Publikováno v: Pharmaceuticals
Pharmaceuticals; Volume 7; Issue 3; Pages: 339-352
Pharmaceuticals, Vol 7, Iss 3, Pp 339-352 (2014)
Pharmaceuticals, 7 (3)
Cannabinoid receptor subtype 2 (CB2) has been shown to be up-regulated in activated microglia and therefore plays an important role in neuroinflammatory and neurodegenerative diseases such as multiple sclerosis, amyotrophic lateral sclerosis and Alzh
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::514b36b4ab22147b6050cb28800de841
http://europepmc.org/articles/PMC3978495
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5
Radiolabeling and in vitro /in vivo evaluation of N-(1-adamantyl)-8-methoxy-4-oxo-1-phenyl-1,4-dihydroquinoline-3-carboxamide as a PET probe for imaging cannabinoid type 2 receptor
Autor: Roger Schibli, Adrienne Müller, Simon M. Ametamey, Roger Slavik, Markus Weber, Daniel Bieri, Stjepko Cermak, Konstantin Drandarov, Linjing Mu, Stefanie-Dorothea Krämer
Publikováno v: Journal of Neurochemistry. 126:616-624
The cannabinoid type 2 (CB2) receptor plays an important role in neuroinflammatory and neurodegenerative diseases such as multiple sclerosis, amyotrophic lateral sclerosis, and Alzheimer’s disease and is therefore a very promising target for therap
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a2db112f8d47e67811a325e50d9ca907
https://doi.org/10.1111/jnc.12354
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6
Synthesis and biological evaluation of a new acyclic pyrimidine derivative as a probe for imaging herpes simplex virus type 1 thymidine kinase gene expression
Autor: Andrijana Meščić, Simon M. Ametamey, Adrienne Müller, Roger Slavik, Thomas Betzel, Silvana Raić-Malić, Stjepko Cermak
Publikováno v: Molecules
Molecules, 18 (7)
Molecules, Vol 18, Iss 7, Pp 8535-8549 (2013)
Volume 18
Issue 7
Pages 8535-8549
With the idea of finding a more selective radiotracer for imaging herpes simplex virus type 1 thymidine kinase (HSV1-tk) gene expression by means of positron emission tomography (PET), a novel [18F]fluorine radiolabeled pyrimidine with 4-hydroxy-3-(h
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::180e1c40dcd044329d08c7b4ff78e9a3
http://www.mdpi.com/1420-3049/18/7/8535
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7
Synthesis and Biological Evaluation of Quinoxaline Derivatives for PET Imaging of the NMDA Receptor
Autor: Selena Milicevic Sephton, Peter T. Vetterli, Aristeidis Chiotellis, Adrienne Müller Herde, Sylvia Roscales, Roger Schibli, Simon M. Ametamey, Yves Auberson, Valentina Pedani, Stjepko Cermak
Publikováno v: Helvetica Chimica Acta. 100:e1700204
Due to the biological complexity of the N-methyl-d-aspartate receptor (NMDAR), the development of a positron emission tomography radiotracer for the imaging of NMDAR has met with limited success. Recent studies have established the presence of GluN2A
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::55bc13a3fce301476e61b911b387afcc
https://doi.org/10.1002/hlca.201700204
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9
Development and evaluation of novel PET tracers for imaging cannabinoid receptor type 2 in brain
Autor: Markus Weber, Roger Slavik, Stjepko Cermak, Daniel Bieri, Roger Schibli, Simon M. Ametamey, Linjing Mu, Adrienne Müller, Stefanie D. Krämer
Publikováno v: CHIMIA, Vol 68, Iss 4 (2014)
The cannabinoid receptor type 2 (CB2) has a very low expression level in brain tissue under basal conditions, but it is up-regulated in diverse pathological conditions. Two promising lead structures from the literature, N-((3S,5S,7S)-adamantan-1-yl)-
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c9d1a8a573431588ffc27238f9455bd3
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10
Akademický článek
Synthesis and Biological Evaluation of a New Acyclic Pyrimidine Derivative as a Probe for Imaging Herpes Simplex Virus Type 1 Thymidine Kinase Gene Expression
Autor: Simon M. Ametamey, Silvana Raić-Malić, Stjepko Čermak, Roger Slavik, Adrienne Müller, Thomas Betzel, Andrijana Meščić
Publikováno v: Molecules, Vol 18, Iss 7, Pp 8535-8549 (2013)
With the idea of finding a more selective radiotracer for imaging herpes simplex virus type 1 thymidine kinase (HSV1-tk) gene expression by means of positron emission tomography (PET), a novel [18F]fluorine radiolabeled pyrimidine with 4-hydroxy-3-(h
Externí odkaz: https://doaj.org/article/111491df8bfe4cd79141878d67e2890f
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