(Epi)genomic heterogeneity of pancreatic islet function and failure in type 2 diabetes

Autor: Lawlor, Nathan, Stitzel, Michael L.

Publikováno v: In Molecular Metabolism September 2019 27 Supplement:S15-S24

A Common Type 2 Diabetes Risk Variant Potentiates Activity of an Evolutionarily Conserved Islet Stretch Enhancer and Increases C2CD4A and C2CD4B Expression

Autor: Kycia, Ina, Wolford, Brooke N., Huyghe, Jeroen R., Fuchsberger, Christian, Vadlamudi, Swarooparani, Kursawe, Romy, Welch, Ryan P., Albanus, Ricardo d’Oliveira, Uyar, Asli, Khetan, Shubham, Lawlor, Nathan, Bolisetty, Mohan, Mathur, Anubhuti, Kuusisto, Johanna, Laakso, Markku, Ucar, Duygu, Mohlke, Karen L., Boehnke, Michael, Collins, Francis S., Parker, Stephen C.J., Stitzel, Michael L.

Publikováno v: In The American Journal of Human Genetics 5 April 2018 102(4):620-635

Genomics of Islet (Dys)function and Type 2 Diabetes

Autor: Lawlor, Nathan, Khetan, Shubham, Ucar, Duygu, Stitzel, Michael L.

Publikováno v: In Trends in Genetics April 2017 33(4):244-255

Simulation of Finnish Population History, Guided by Empirical Genetic Data, to Assess Power of Rare-Variant Tests in Finland

Autor: Flannick, Jason, Manning, Alisa, Hartl, Christopher, Agarwala, Vineeta, Fontanillas, Pierre, Green, Todd, Banks, Eric, DePristo, Mark, Poplin, Ryan, Shakir, Khalid, Fennell, Timothy, Murphy, Jacquelyn, Burtt, Noël, Gabriel, Stacey, Altshuler, David, Fuchsberger, Christian, Kang, Hyun Min, Sim, Xueling, Ma, Clement, Locke, Adam, Blackwell, Thomas, Jackson, Anne, Teslovich, Tanya, Stringham, Heather, Chines, Peter, Kwan, Phoenix, Huyghe, Jeroen, Tan, Adrian, Jun, Goo, Stitzel, Michael, Bergman, Richard N., Bonnycastle, Lori, Tuomilehto, Jaakko, Collins, Francis S., Scott, Laura, Mohlke, Karen, Abecasis, Gonçalo, Boehnke, Michael, Strom, Tim, Gieger, Christian, Müller-Nurasyid, Martina, Grallert, Harald, Kriebel, Jennifer, Ried, Janina, Hrabé de Angelis, Martin, Huth, Cornelia, Meisinger, Christa, Peters, Annette, Rathmann, Wolfgang, Strauch, Konstantin, Meitinger, Thomas, Kravic, Jasmina, Ladenvall, Claes, Toumi, Tiinamaija, Isomaa, Bo, Groop, Leif, Gaulton, Kyle, Moutsianas, Loukas, Rivas, Manny, Pearson, Richard, Mahajan, Anubha, Prokopenko, Inga, Kumar, Ashish, Perry, John, Chen, Jeff, Howie, Bryan, van de Bunt, Martijn, Small, Kerrin, Lindgren, Cecilia, Lunter, Gerton, Robertson, Neil, Rayner, Will, Morris, Andrew, Buck, David, Hattersley, Andrew, Spector, Tim, McVean, Gil, Frayling, Tim, Donnelly, Peter, McCarthy, Mark, Wang, Sophie R., Chiang, Charleston W.K., Hirschhorn, Joel N.

Publikováno v: In The American Journal of Human Genetics 1 May 2014 94(5):710-720

Modeling islet enhancers using deep learning identifies candidate causal variants at loci associated with T2D and glycemic traits.

Autor: Hudaiberdiev, Sanjarbek, Taylor, D. Leland, Wei Song, Narisu, Narisu, Bhuiyan, Redwan M., Taylor, Henry J., Xuming Tang, Tingfen Yan, Swift, Amy J., Bonnycastle, Lori L., Shuibing Chen, Stitzel, Michael L., Erdos, Michael R., Ovcharenko, Ivan, Collins, Francis S.

Publikováno v: Proceedings of the National Academy of Sciences of the United States of America; 8/29/2023, Vol. 120 Issue 35, p1-8, 73p