Comparative investigation of the novel radiotracers (R)- and (S)-[18F]fluspidine for imaging of σ1 receptors by PET

Autor: Deuther-Conrad, W., Becker, G., Patt, M., Donat, C. K., Kranz, M., Stittsworth, S., Holl, K., Habermann, B., Fischer, S., Wenzel, B., Mishchenko, L., Hesse, S., Steinbach, J., Wünsch, B., Lever, S. Z., Sabri, O., Brust, P.

Publikováno v: The 10th International Symposium on Funktional NeuroReceptor Mapping of the Living Brain, 21.-24.05.2014, Amsterdam, The Netherlands

Objectives Sigma1 receptor (σ1), found in plasma, mitochondrial and endoplasmic reticular membranes and involved in many cellular functions of the endocrine, immune, and nervous systems, is a promising target for novel concepts in diagnostics and th

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=od______4577::34d89cbf97af5cbcb7c3223cf51af025
https://www.hzdr.de/publications/Publ-20199-1

Discovery of enantioselective suitability of (R)-(+)- and (S)-(-)-[18F]fluspidine for σ1 receptor imaging

Autor: Deuther-Conrad, W., Maisonial, A., Patt, M., Stittsworth, S., Becker, G., Habermann, B., Holl, K., Schepmann, D., Funke, U., Donat, C. K., Fischer, S., Hiller, A., Wenzel, B., Steinbach, J., Wünsch, B., Lever, S., Hesse, S., Sabri, O., Brust, P.

Publikováno v: The 20th International Symposium on Radiopharmaceutical Sciences-ISRS2013, 12.-17.05.2013, Jeju, South Korea
Journal of Labelled Compounds and Radiopharmaceuticals 56(2013)1, S55-S55

Objectives: It is widely accepted that σ1 receptors represent a novel biological target for the possible pharmacological treatment of cancer and several brain diseases, e.g. depression and neurodegeneration. From a series of σ1-specific racemic 18F

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=dedup_wf_001::47ebfb1a12a4a8ef0fe4ffb6db853804
https://www.hzdr.de/publications/Publ-18204-1

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