Zobrazeno 1 - 10
of 86
pro vyhledávání: '"Stirling Churchman"'
Autor:
Allison Coté, Aoife O'Farrell, Ian Dardani, Margaret Dunagin, Chris Coté, Yihan Wan, Sareh Bayatpour, Heather L Drexler, Katherine A Alexander, Fei Chen, Asmamaw T Wassie, Rohan Patel, Kenneth Pham, Edward S Boyden, Shelly Berger, Jennifer Phillips-Cremins, L Stirling Churchman, Arjun Raj
Publikováno v:
eLife, Vol 12 (2024)
Splicing is the stepwise molecular process by which introns are removed from pre-mRNA and exons are joined together to form mature mRNA sequences. The ordering and spatial distribution of these steps remain controversial, with opposing models suggest
Externí odkaz:
https://doaj.org/article/e2adfd4a05a34bda852301bfb43444b5
Autor:
Danny Bergeron, Laurence Faucher-Giguère, Ann-Kathrin Emmerichs, Karine Choquet, Kristina Sungeun Song, Gabrielle Deschamps-Francoeur, Étienne Fafard-Couture, Andrea Rivera, Sonia Couture, L. Stirling Churchman, Florian Heyd, Sherif Abou Elela, Michelle S. Scott
Publikováno v:
Genome Biology, Vol 24, Iss 1, Pp 1-25 (2023)
Abstract Background Small nucleolar RNAs (snoRNAs) are abundant noncoding RNAs best known for their involvement in ribosomal RNA maturation. In mammals, most expressed snoRNAs are embedded in introns of longer genes and produced through transcription
Externí odkaz:
https://doaj.org/article/9cacce3aeec94e56b9bf6649e0fa23d4
Autor:
Iliana Soto, Mary Couvillion, Katja G. Hansen, Erik McShane, J. Conor Moran, Antoni Barrientos, L. Stirling Churchman
Publikováno v:
Genome Biology, Vol 23, Iss 1, Pp 1-24 (2022)
Abstract Background Oxidative phosphorylation (OXPHOS) complexes consist of nuclear and mitochondrial DNA-encoded subunits. Their biogenesis requires cross-compartment gene regulation to mitigate the accumulation of disproportionate subunits. To dete
Externí odkaz:
https://doaj.org/article/1bba262044ad4470b6b7d87fc862e8de
Publikováno v:
Genome Biology, Vol 22, Iss 1, Pp 1-35 (2021)
Abstract A bottleneck in high-throughput functional genomics experiments is identifying the most important genes and their relevant functions from a list of gene hits. Gene Ontology (GO) enrichment methods provide insight at the gene set level. Here,
Externí odkaz:
https://doaj.org/article/4ab24d5390b14e418f2e49741c57b10a
Autor:
Mary Couvillion, Kevin M Harlen, Kate C Lachance, Kristine L Trotta, Erin Smith, Christian Brion, Brendan M Smalec, L Stirling Churchman
Publikováno v:
eLife, Vol 11 (2022)
Understanding the complex network that regulates transcription elongation requires the quantitative analysis of RNA polymerase II (Pol II) activity in a wide variety of regulatory environments. We performed native elongating transcript sequencing (NE
Externí odkaz:
https://doaj.org/article/423671e31f8c4a3383b5bd9ff2afd815
Autor:
Blake W Tye, Nicoletta Commins, Lillia V Ryazanova, Martin Wühr, Michael Springer, David Pincus, L Stirling Churchman
Publikováno v:
eLife, Vol 8 (2019)
To achieve maximal growth, cells must manage a massive economy of ribosomal proteins (r-proteins) and RNAs (rRNAs) to produce thousands of ribosomes every minute. Although ribosomes are essential in all cells, natural disruptions to ribosome biogenes
Externí odkaz:
https://doaj.org/article/b993899821514397b4eeae216b911ee0
Autor:
Kevin M Harlen, L Stirling Churchman
Publikováno v:
Molecular Systems Biology, Vol 13, Iss 1, Pp 1-14 (2017)
Abstract Transcription, RNA processing, and chromatin‐related factors all interact with RNA polymerase II (Pol II) to ensure proper timing and coordination of transcription and co‐transcriptional processes. Many transcription elongation regulator
Externí odkaz:
https://doaj.org/article/879d18a351064d04b8a15d52037ae01f
Autor:
Kevin M. Harlen, Kristine L. Trotta, Erin E. Smith, Mohammad M. Mosaheb, Stephen M. Fuchs, L. Stirling Churchman
Publikováno v:
Cell Reports, Vol 15, Iss 10, Pp 2147-2158 (2016)
Transcription controls splicing and other gene regulatory processes, yet mechanisms remain obscure due to our fragmented knowledge of the molecular connections between the dynamically phosphorylated RNA polymerase II (Pol II) C-terminal domain (CTD)
Externí odkaz:
https://doaj.org/article/1dabfdeb9f0e41caa4a93ad2a6832f61
Autor:
Danya J. Martell, Hope E. Merens, Claudia Fiorini, Alexis Caulier, Jacob C. Ulirsch, Robert Ietswaart, Karine Choquet, Giovanna Graziadei, Valentina Brancaleoni, Maria Domenica Cappellini, Caroline Scott, Nigel Roberts, Melanie Proven, Noémi BA Roy, Christian Babbs, Douglas R. Higgs, Vijay G. Sankaran, L. Stirling Churchman
SummaryThe controlled release of promoter-proximal paused RNA polymerase II (Pol II) into productive elongation is a major step in gene regulation. However, functional analysis of Pol II pausing is difficult because factors that regulate pause releas
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::800915e53878822adec809d30f93ead3
https://doi.org/10.1101/2023.03.03.23286760
https://doi.org/10.1101/2023.03.03.23286760
Autor:
Erik McShane, Mary Couvillion, Robert Ietswaart, Gyan Prakash, Brendan M. Smalec, Iliana Soto, Autum R. Baxter-Koenigs, Karine Choquet, L. Stirling Churchman
Publikováno v:
bioRxiv
Mitochondria play critical roles in cellular metabolism, primarily by serving as the site of assembly and function of the oxidative phosphorylation (OXPHOS) machinery. The OXPHOS proteins are encoded by mitochondrial DNA (mtDNA) and nuclear DNA, whic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::42b246668b9b51b62a149239740fd4c7
https://europepmc.org/articles/PMC9948965/
https://europepmc.org/articles/PMC9948965/