Výsledky vyhledávání - "Stinne W. Hansen"

Akademický článek

Advances in the synthesis of functionalised pyrrolotetrathiafulvalenes

Autor: Luke J. O’Driscoll, Sissel S. Andersen, Marta V. Solano, Dan Bendixen, Morten Jensen, Troels Duedal, Jess Lycoops, Cornelia van der Pol, Rebecca E. Sørensen, Karina R. Larsen, Kenneth Myntman, Christian Henriksen, Stinne W. Hansen, Jan O. Jeppesen

Publikováno v: Beilstein Journal of Organic Chemistry, Vol 11, Iss 1, Pp 1112-1122 (2015)

The electron-donor and unique redox properties of the tetrathiafulvalene (TTF, 1) moiety have led to diverse applications in many areas of chemistry. Monopyrrolotetrathiafulvalenes (MPTTFs, 4) and bispyrrolotetrathiafulvalenes (BPTTFs, 5) are useful

Externí odkaz: https://doaj.org/article/92c2979bbee14b42bd2077ef60ae3b96

Zobrazit plný text záznamu

Design and Synthesis of a Series of l-trans-4-Substituted Prolines as Selective Antagonists for the Ionotropic Glutamate Receptors Including Functional and X-ray Crystallographic Studies of New Subtype Selective Kainic Acid Receptor Subtype 1 (GluK1) Antagonist (2S,4R)-4-(2-Carboxyphenoxy)pyrrolidine-2-carboxylic Acid

Autor: Liwei Han, Stinne W. Hansen, Karla Frydenvang, Lennart Bunch, Karina Koch, Claudia G. Delgar, Charlotte Møller, Tri H. V. Huynh, Darryl S. Pickering, Niels Krogsgaard-Larsen, Birgitte Nielsen, Patricia M.G.E. Brown, Jette S. Kastrup, Derek Bowie

Publikováno v: Journal of Medicinal Chemistry. 60:441-457

Ionotropic glutamate receptor antagonists are valuable tool compounds for studies of neurological pathways in the central nervous system. On the basis of rational ligand design, a new class of selective antagonists, represented by (2S,4R)-4-(2-carbox

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::cf41acb2aaafe10e76c5b656ba2b0bfb
https://doi.org/10.1021/acs.jmedchem.6b01516

Zobrazit plný text záznamu

Bioavailability Studies and in vitro Profiling of the Selective Excitatory Amino Acid Transporter Subtype 1 (EAAT1) Inhibitor UCPH-102

Autor: Anette L. Eriksen, Stinne W. Hansen, Josep A. Ruiz, Christoffer Bundgaard, Jesper F. Bastlund, Isabell Haym, Bjarke Abrahamsen, Anders A. Jensen, Lennart Bunch, Mikko Gynther, Tri H. V. Huynh, Mette N. Erichsen, Walden E. Bjørn-Yoshimoto, Martin Holst Friborg Pedersen

Publikováno v: ChemMedChem. 11:403-419

Although the selective excitatory amino acid transporter subtype 1 (EAAT1) inhibitor UCPH-101 has become a standard pharmacological tool compound for in vitro and ex vivo studies in the EAAT research field, its inability to penetrate the blood-brain

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6d0f875dae7a0b00cd26818da7ddad1a
https://doi.org/10.1002/cmdc.201500527

Zobrazit plný text záznamu

Autor: Niels, Krogsgaard-Larsen, Claudia G, Delgar, Karina, Koch, Patricia M G E, Brown, Charlotte, Møller, Liwei, Han, Tri H V, Huynh, Stinne W, Hansen, Birgitte, Nielsen, Derek, Bowie, Darryl S, Pickering, Jette Sandholm, Kastrup, Karla, Frydenvang, Lennart, Bunch

Publikováno v: Journal of medicinal chemistry. 60(1)

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::3ae2e6b559db049dff24ff758b719a0f
https://pubmed.ncbi.nlm.nih.gov/28005385

Zobrazit plný text záznamu

Identification of a New Class of Selective Excitatory Amino Acid Transporter Subtype 1 (EAAT1) Inhibitors Followed by a Structure-Activity Relationship Study

Autor: Walden E. Bjørn-Yoshimoto, Anders A. Jensen, Stinne W. Hansen, Lennart Bunch, Jacob C. Hansen, Bjarke Abrahamsen, Bingru Fu, Mette N. Erichsen

Publikováno v: Journal of medicinal chemistry. 59(19)

Screening of a small compound library at the three excitatory amino acid transporter subtypes 1-3 (EAAT1-3) resulted in the identification of compound (Z)-4-chloro-3-(5-((3-(2-ethoxy-2-oxoethyl)-2,4-dioxothiazolidin-5-ylidene)methyl)furan-2-yl)benzoi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::399df88bc78016dff3140765282e6162
https://pubmed.ncbi.nlm.nih.gov/27626828

Zobrazit plný text záznamu

New Insight into the Structure-Activity Relationships of the Selective Excitatory Amino Acid Transporter Subtype 1 (EAAT1) Inhibitors UCPH-101 and UCPH-102

Autor: Josep A. Ruiz, Stinne W. Hansen, Mette N. Erichsen, Anette L. Eriksen, Walden E. Bjørn-Yoshimoto, Morten Storgaard, J.B. Hansen, Anders A. Jensen, Isabell Haym, Bjarke Abrahamsen, Lennart Bunch, Tri H. V. Huynh

Publikováno v: ChemMedChem. 11(4)

In the present study, we made further investigations on the structure-activity requirements of the selective excitatory amino acid transporter 1 (EAAT1) inhibitor, 2-amino-4-(4-methoxyphenyl)-7-(naphthalen-1-yl)-5-oxo-5,6,7,8-tetrahydro-4H-chromene-3

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e2bb18f7171ca4b9be132e3110579931
https://pubmed.ncbi.nlm.nih.gov/26757239

Zobrazit plný text záznamu