In vivo monoclonal antibody efficacy against SARS-CoV-2 variant strains.

Autor: Chen RE; Department of Medicine, Washington University School of Medicine, St Louis, MO, USA.; Department of Pathology and Immunology, Washington University School of Medicine, St Louis, MO, USA., Winkler ES; Department of Medicine, Washington University School of Medicine, St Louis, MO, USA.; Department of Pathology and Immunology, Washington University School of Medicine, St Louis, MO, USA., Case JB; Department of Medicine, Washington University School of Medicine, St Louis, MO, USA., Aziati ID; Department of Medicine, Washington University School of Medicine, St Louis, MO, USA., Bricker TL; Department of Medicine, Washington University School of Medicine, St Louis, MO, USA., Joshi A; Department of Medicine, Washington University School of Medicine, St Louis, MO, USA., Darling TL; Department of Medicine, Washington University School of Medicine, St Louis, MO, USA., Ying B; Department of Medicine, Washington University School of Medicine, St Louis, MO, USA., Errico JM; Department of Pathology and Immunology, Washington University School of Medicine, St Louis, MO, USA., Shrihari S; Department of Medicine, Washington University School of Medicine, St Louis, MO, USA., VanBlargan LA; Department of Medicine, Washington University School of Medicine, St Louis, MO, USA., Xie X; Department of Biochemistry and Molecular Biology, University of Texas Medical Branch, Galveston, TX, USA., Gilchuk P; Vanderbilt Vaccine Center, Vanderbilt University Medical Center, Nashville, TN, USA., Zost SJ; Vanderbilt Vaccine Center, Vanderbilt University Medical Center, Nashville, TN, USA., Droit L; Department of Molecular Microbiology, Washington University School of Medicine, St Louis, MO, USA., Liu Z; Department of Molecular Microbiology, Washington University School of Medicine, St Louis, MO, USA., Stumpf S; Department of Molecular Microbiology, Washington University School of Medicine, St Louis, MO, USA., Wang D; Department of Molecular Microbiology, Washington University School of Medicine, St Louis, MO, USA., Handley SA; Department of Pathology and Immunology, Washington University School of Medicine, St Louis, MO, USA., Stine WB Jr; AbbVie Bioresearch Center, Worcester, MA, USA., Shi PY; Department of Biochemistry and Molecular Biology, University of Texas Medical Branch, Galveston, TX, USA.; Department of Microbiology and Immunology, University of Texas Medical Branch, Galveston, TX, USA.; Sealy Institute for Vaccine Sciences, University of Texas Medical Branch, Galveston, TX, USA., Davis-Gardner ME; Center for Childhood Infections and Vaccines of Children's Healthcare of Atlanta, Department of Pediatrics, Emory Vaccine Center, Emory University School of Medicine, Atlanta, GA, USA., Suthar MS; Center for Childhood Infections and Vaccines of Children's Healthcare of Atlanta, Department of Pediatrics, Emory Vaccine Center, Emory University School of Medicine, Atlanta, GA, USA., Knight MG; Department of Microbiology and Immunology, University of California San Francisco, San Francisco, CA, USA., Andino R; Department of Microbiology and Immunology, University of California San Francisco, San Francisco, CA, USA., Chiu CY; Department of Laboratory Medicine, University of California San Francisco, San Francisco, CA, USA.; Department of Medicine, University of California San Francisco, San Francisco, CA, USA., Ellebedy AH; Department of Pathology and Immunology, Washington University School of Medicine, St Louis, MO, USA.; Andrew M. and Jane M. Bursky Center for Human Immunology and Immunotherapy Programs, Washington University School of Medicine, St Louis, MO, USA.; Center for Vaccines and Immunity to Microbial Pathogens, Washington University School of Medicine, St Louis, MO, USA., Fremont DH; Department of Pathology and Immunology, Washington University School of Medicine, St Louis, MO, USA.; Department of Molecular Microbiology, Washington University School of Medicine, St Louis, MO, USA.; Department of Biochemistry and Molecular Biophysics, Washington University School of Medicine, St Louis, MO, USA., Whelan SPJ; Department of Molecular Microbiology, Washington University School of Medicine, St Louis, MO, USA., Crowe JE Jr; Vanderbilt Vaccine Center, Vanderbilt University Medical Center, Nashville, TN, USA.; Department of Pediatrics, Vanderbilt University Medical Center, Nashville, TN, USA.; Department of Pathology, Microbiology and Immunology, Vanderbilt University Medical Center, Nashville, TN, USA., Purcell L; Vir Biotechnology, St Louis, MO, USA., Corti D; Humabs BioMed SA, a subsidiary of Vir Biotechnology, Bellinzona, Switzerland., Boon ACM; Department of Medicine, Washington University School of Medicine, St Louis, MO, USA.; Department of Pathology and Immunology, Washington University School of Medicine, St Louis, MO, USA.; Department of Molecular Microbiology, Washington University School of Medicine, St Louis, MO, USA., Diamond MS; Department of Medicine, Washington University School of Medicine, St Louis, MO, USA. diamond@wusm.wustl.edu.; Department of Pathology and Immunology, Washington University School of Medicine, St Louis, MO, USA. diamond@wusm.wustl.edu.; Department of Molecular Microbiology, Washington University School of Medicine, St Louis, MO, USA. diamond@wusm.wustl.edu.; Andrew M. and Jane M. Bursky Center for Human Immunology and Immunotherapy Programs, Washington University School of Medicine, St Louis, MO, USA. diamond@wusm.wustl.edu.; Center for Vaccines and Immunity to Microbial Pathogens, Washington University School of Medicine, St Louis, MO, USA. diamond@wusm.wustl.edu.

Publikováno v: Nature [Nature] 2021 Aug; Vol. 596 (7870), pp. 103-108. Date of Electronic Publication: 2021 Jun 21.

Intraneuronal Aβ detection in 5xFAD mice by a new Aβ-specific antibody.

Autor: Youmans KL; Department of Anatomy and Cell Biology, University of Illinois at Chicago, IL 60612, USA., Tai LM, Kanekiyo T, Stine WB Jr, Michon SC, Nwabuisi-Heath E, Manelli AM, Fu Y, Riordan S, Eimer WA, Binder L, Bu G, Yu C, Hartley DM, LaDu MJ

Publikováno v: Molecular neurodegeneration [Mol Neurodegener] 2012 Mar 16; Vol. 7, pp. 8. Date of Electronic Publication: 2012 Mar 16.

Small assemblies of unmodified amyloid beta-protein are the proximate neurotoxin in Alzheimer's disease.

Autor: Klein WL; Department of Neurobiology and Physiology, Cognitive Neurology and Alzheimer's Disease Center, Northwestern University Institute for Neuroscience, Evanston, IL, USA., Stine WB Jr, Teplow DB

Publikováno v: Neurobiology of aging [Neurobiol Aging] 2004 May-Jun; Vol. 25 (5), pp. 569-80.

Oligomeric and fibrillar species of amyloid-beta peptides differentially affect neuronal viability.

Autor: Dahlgren KN; Department of Medicine, Evanston Northwestern Healthcare Research Institute, Evanston, Illinois 60201, USA., Manelli AM, Stine WB Jr, Baker LK, Krafft GA, LaDu MJ

Publikováno v: The Journal of biological chemistry [J Biol Chem] 2002 Aug 30; Vol. 277 (35), pp. 32046-53. Date of Electronic Publication: 2002 Jun 10.