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Pre-clinical effects of highly potent MEK1/2 inhibitors on rat cerebral vasculature after organ culture and subarachnoid haemorrhage

Autor: Kristian Agmund Haanes, Karin Warfvinge, Stine Spray, Sara Ellinor Johansson, Lars Edvinsson, Simon Topp Christensen, Anne-Sofie Grell

Publikováno v: Clinical Science. 133:1797-1811

Background: Aneurysmal subarachnoid haemorrhage (SAH) is a variant of haemorrhagic stroke with a striking 50% mortality rate. In addition to the initial insult, secondary delayed brain injury may occur days after the initial ischemic insult and is as

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9279bdafe257aa35101cac33a7cbc499
https://doi.org/10.1042/cs20190636

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Subacute phase of subarachnoid haemorrhage in female rats: Increased intracranial pressure, vascular changes and impaired sensorimotor function

Autor: Stine Spray, Kristian Agmund Haanes, Lars Edvinsson, Sara Ellinor Johansson

Publikováno v: Microvascular Research. 135:104127

Objective Early brain injury (EBI) and delayed cerebral ischemia (DCI) after subarachnoid haemorrhage (SAH) has devastating consequences but therapeutic options and the underlying pathogenesis remain poorly understood despite extensive preclinical an

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::664d48dfe73c8bbdf5e218f7d778e28b
https://doi.org/10.1016/j.mvr.2020.104127

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Enhanced contractility of intraparenchymal arterioles after global cerebral ischaemia in rat - new insights into the development of delayed cerebral hypoperfusion

Autor: Stine Spray, Paul A.T. Kelly, Sara Johansson, Gro Klitgaard Povlsen, Lars Edvinsson, Karin Warfvinge, Aneta Radziwon-Balicka, Kristian Agmund Haanes

Publikováno v: Acta Physiologica. 220:417-431

Aim Delayed cerebral hypoperfusion is a secondary complication found in the days after transient global cerebral ischemia that worsens the ischemic damage inflicted by the initial transient episode of global cerebral ischemia. A recent study demonstr

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a40d2ed40e84c023362a37fc5bc4c5d0
https://doi.org/10.1111/apha.12834

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Alterations in the Cerebral Microvascular Proteome Expression Profile After Transient Global Cerebral Ischemia in Rat

Autor: Alistair V G Edwards, Gro Klitgaard Povlsen, Aneta Radziwon-Balicka, Martin R. Larsen, Sara E Johansson, Lars Edvinsson, Stine Spray

Publikováno v: Spray, S, Johansson, S E, Edwards, A V G, Larsen, M R, Radziwon-Balicka, A, Povlsen, G K & Edvinsson, L 2017, ' Alterations in the Cerebral Microvascular Proteome Expression Profile After Transient Global Cerebral Ischemia in Rat ', Journal of Molecular Neuroscience, vol. 61, no. 3, pp. 396–411 . https://doi.org/10.1007/s12031-016-0875-8

This study aimed at obtaining an in-depth mapping of expressional changes of the cerebral microvasculature after transient global cerebral ischemia (GCI) and the impact on these GCI-induced expressional changes of post-GCI treatment with a mitogen-ac

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2084d96a543585950c6b29f38bee40fc
https://doi.org/10.1007/s12031-016-0875-8

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Improved assessment of outcomes following transient global cerebral ischemia in mice

Autor: Stine Spray, Lars Edvinsson

Publikováno v: Experimental brain research. 234(7)

Mouse models of global cerebral ischemia (GCI) allow experimental examination of cerebral pathophysiology in genetically modified mice and fast screening of new treatment strategies. Various surgical protocols of GCI-induction in mice have been publi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::133adfc7177b2461093eebb8a5eb52ac
https://pubmed.ncbi.nlm.nih.gov/26914479

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New insights on pyrimidine signalling within the arterial vasculature - Different roles for P2Y2 and P2Y6 receptors in large and small coronary arteries of the mouse

Autor: Jean-Marie Boeynaems, Niklas Rye Jørgensen, Lars Edvinsson, Bernard Robaye, Stine Spray, Kristian Agmund Haanes, Susanne Syberg

Publikováno v: Journal of molecular and cellular cardiology. 93

Extracellular pyrimidines activate P2Y receptors on both smooth muscle cells and endothelial cells, leading to vasoconstriction and relaxation respectively. The aim of this study was to utilize P2Y knock-out (KO) mice to determine which P2Y receptor

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::85a92b95a83ccfa1351d6826052ad78a
https://pubmed.ncbi.nlm.nih.gov/26827897

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Reduced Mechanical Stretch Induces Enhanced Endothelin B Receptor-Mediated Contractility via Activation of Focal Adhesion Kinase and Extracellular Regulated Kinase 1/2 in Cerebral Arteries from Rat

Autor: Lars Edvinsson, Gry Freja Skovsted, Majid Sheykhzade, Stine Spray, Marianne N. P. Rasmussen, Karin Warfvinge

Publikováno v: Basicclinical pharmacologytoxicology. 119(1)

Cerebral ischaemia results in enhanced endothelin B (ETB ) receptor-mediated contraction and receptor protein expression in the affected cerebrovascular smooth muscle cells (SMC). Organ culture of cerebral arteries is a method to induce similar alter

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::add4766eb99dcea94ed504be4d68ad01
https://pubmed.ncbi.nlm.nih.gov/26781487

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