Zobrazeno 1 - 10
of 79
pro vyhledávání: '"Stine Nygaard"'
Autor:
Rikke Hebo Larsen, Cecilie Utke Rank, Kathrine Grell, Lisbeth Nørgaard Møller, Ulrik Malthe Overgaard, Peter Kampmann, Jacob Nersting, Matilda Degn, Stine Nygaard Nielsen, Helle Holst, Birgitte Klug Albertsen, Peder Skov Wehner, Michael Thude Callesen, Jukka Kanerva, Thomas Leth Frandsen, Bodil Als-Nielsen, Lisa Lyngsie Hjalgrim, Kjeld Schmiegelow
Publikováno v:
Haematologica, Vol 106, Iss 11 (2021)
Maintenance therapy containing methotrexate and 6-mercapto - purine is essential to cure acute lymphoblastic leukemia (ALL). Cytotoxicity is elicited by incorporation of thioguanine nucleotides into DNA (DNA-TG), and higher leukocyte DNA-TG is associ
Externí odkaz:
https://doaj.org/article/824bdbd3c5524dbba9ba9095b3184cb4
Autor:
Nielsen, Stine Nygaard, Grell, Kathrine, Nersting, Jacob, Abrahamsson, Jonas, Lund, Bendik, Kanerva, Jukka, Jónsson, Ólafur Gísli, Vaitkeviciene, Goda, Pruunsild, Kaie, Hjalgrim, Lisa Lyngsie, Schmiegelow, Kjeld
Publikováno v:
In The Lancet Oncology April 2017 18(4):515-524
Akademický článek
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Autor:
Tekla Harju, Anri Hurme-Niiranen, Maria Suo-Palosaari, Stine Nygaard Nielsen, Reetta Hinttala, Kjeld Schmiegelow, Johanna Uusimaa, Arja Harila, Riitta Niinimäki
Publikováno v:
The Pharmacogenomics Journal.
Hepatotoxicity is a frequent complication during maintenance therapy of acute lymphoblastic leukemia (ALL) with 6-mercaptopurine and methotrexate. Elevated levels of methylated 6-mercaptopurine metabolites (MeMP) are associated with hepatotoxicity. H
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1ef45bdad16f2577773559ebccd31705
https://doi.org/10.1038/s41397-023-00303-0
https://doi.org/10.1038/s41397-023-00303-0
Autor:
Kathrine Grell, Lisa Lyngsie Hjalgrim, Anja Möricke, Jacob Nersting, Jaitri Joshi, Bruce Bostrom, Petter Quist-Paulsen, Kim Dalhoff, Bendik Lund, Kristi Lepik, Anthony V. Moorman, Goda Vaitkevičienė, Kjeld Schmiegelow, Daniel Murdy, Jukka Kanerva, Olafur G. Jonsson, Linea Natalie Toksvang, Bodil Als-Nielsen, Martin Zimmermann, Stine Nygaard Nielsen, Ajay Vora, Matilda Degn, Laimonas Griskevicius, Jonas Abrahamsson
Publikováno v:
Leukemia. 36:33-41
Methotrexate/6-mercaptopurine maintenance therapy improves acute lymphoblastic leukemia (ALL) outcome. Cytotoxicity is mediated by DNA incorporation of thioguanine nucleotides (DNA-TG). We investigated the association of DNA-TG to relapse risk in 1 9
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e569cafaa116267961cde2bf2ff0793f
https://doi.org/10.1038/s41375-021-01182-9
https://doi.org/10.1038/s41375-021-01182-9
Autor:
Jacob Nersting, Nina Toft, Linea Natalie Toksvang, Thomas Frandsen, Stine Nygaard Nielsen, Laimonas Griskevicius, Signe Sloth Mogensen, Riitta Niinimäki, Joel Joelsson, Ulrik Malthe Overgaard, Olafur G. Jonsson, Kjeld Schmiegelow, Jonas Abrahamsson, Cecilie Utke Rank, Kathrine Grell, Arja Harila-Saari, Petter Quist-Paulsen, Goda Vaitkevičienė, Liv Andrés-Jensen
Publikováno v:
Cancer Chemotherapy and Pharmacology. 88:911-917
Osteonecrosis is a burdensome treatment-related toxicity that is mostly diagnosed during or soon after 6-mercaptopurine (6MP)/methotrexate (MTX) maintenance therapy for acute lymphoblastic leukemia (ALL), possibly indicating a pathogenic role of thes
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8054a20906d26aad2e3db53924c15560
https://doi.org/10.1007/s00280-021-04316-z
https://doi.org/10.1007/s00280-021-04316-z
Autor:
Kjeld Schmiegelow, Bendik Lund, Kathrine Grell, Stine Nygaard Nielsen, Goda Vaitkeviciene, Jukka Kanerva, Malin Lindqvist Appell, Lisa Lyngsie Hjalgrim, Jacob Nersting, Linea Natalie Toksvang, Jonas Abrahamsson, Kaie Pruunsild, Olafur G. Jonsson
Publikováno v:
Cancer Chemotherapy and Pharmacology. 88:271-279
6-mercaptopurine(6MP)/methotrexate maintenance therapy is essential to reduce relapse of childhood acute lymphoblastic leukemia (ALL). Common germline variants in TPMT cause low activity of thiopurine methyltransferase (TPMT) and higher 6MP metabolit
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8f99ade3e3597a1b0fa951db9d7eb314
https://doi.org/10.1007/s00280-021-04281-7
https://doi.org/10.1007/s00280-021-04281-7
Autor:
Stine Nygaard Nielsen, Jacob Nersting, Anthony V. Moorman, Ajay Vora, Linea Natalie Toksvang, Daniel Murdy, Kathrine Grell, Kjeld Schmiegelow
Publikováno v:
Leukemia. 36:555-557
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4f257a460a9380a37edf21875521f68f
https://doi.org/10.1038/s41375-021-01420-0
https://doi.org/10.1038/s41375-021-01420-0
Autor:
Morten Tulstrup, Jonas Abrahamsson, Ramneek Gupta, Chuang Jiang, Hui Zhang, Lisa Lyngsie Hjalgrim, Kjeld Schmiegelow, Jacob Nersting, Bendik Lund, Jukka Kanerva, Marie Grosjean, Takaya Moriyama, Olafur G. Jonsson, Benjamin Ole Wolthers, Kathrine Grell, Goda Vaitkeviciene, Stine Nygaard Nielsen, Kaie Pruunsild, Ulrik Malthe Overgaard, Jun J. Yang, Rikke Linnemann Nielsen, Petter Quist-Paulsen
Publikováno v:
Blood
Methotrexate (MTX) during maintenance therapy is essential for curing acute lymphoblastic leukemia (ALL), but dosing strategies aiming at adequate treatment intensity are challenged by interindividual differences in drug disposition. To evaluate gene
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::139b1916a4d6dd496b5cf48e187de056
https://doi.org/10.1182/blood.2020005064
https://doi.org/10.1182/blood.2020005064
Autor:
Thomas Frandsen, Ulrik Malthe Overgaard, Peter Kampmann, Matilda Degn, Helle Holst, Rikke Hebo Larsen, Peder Skov Wehner, Lisa Lyngsie Hjalgrim, Stine Nygaard Nielsen, Birgitte Klug Albertsen, Cecilie Utke Rank, Bodil Als-Nielsen, Jacob Nersting, Lisbeth Nørgaard Møller, Kjeld Schmiegelow, Jukka Kanerva, Kathrine Grell, Michael Callesen
Publikováno v:
Larsen, R H, Utke Rank, C, Grell, K, Nørgaard Møller, L, Malthe Overgaard, U, Kampmann, P, Nersting, J, Degn, M, Nygaard Nielsen, S, Holst, H, Klug Albertsen, B, Skov Wehner, P, Thude Callesen, M, Kanerva, J, Leth Frandsen, T, Als-Nielsen, B, Lyngsie Hjalgrim, L & Schmiegelow, K 2021, ' Increments in DNA-thioguanine level during thiopurine enhanced maintenance therapy of acute lymphoblastic leukemia ', Haematologica, vol. 106, no. 11, pp. 2824-2833 . https://doi.org/10.3324/haematol.2020.278166
Larsen, R H, Rank, C U, Grell, K, Møller, L N, Overgaard, U M, Kampmann, P, Nersting, J, Degn, M, Nielsen, S N, Holst, H, Albertsen, B K, Wehner, P S, Callesen, M T, Kanerva, J, Frandsen, T L, Als-Nielsen, B, Hjalgrim, L L & Schmiegelow, K 2021, ' Increments in DNA-thioguanine level during thiopurine-enhanced maintenance therapy of acute lymphoblastic leukemia ', Haematologica, vol. 106, no. 11, pp. 2824-2833 . https://doi.org/10.3324/haematol.2020.278166
Haematologica
Larsen, R H, Utke Rank, C, Grell, K, Nørgaard Møller, L, Malthe Overgaard, U, Kampmann, P, Nersting, J, Degn, M, Nygaard Nielsen, S, Holst, H, Klug Albertsen, B, Skov Wehner, P, Thude Callesen, M, Kanerva, J, Leth Frandsen, T, Als-Nielsen, B, Lyngsie Hjalgrim, L & Schmiegelow, K 2021, ' Increments in DNA-thioguanine level during thiopurine enhanced maintenance therapy of acute lymphoblastic leukemia ', Haematologica, vol. 106, no. 11 . https://doi.org/10.3324/haematol.2020.278166
Larsen, R H, Rank, C U, Grell, K, Møller, L N, Overgaard, U M, Kampmann, P, Nersting, J, Degn, M, Nielsen, S N, Holst, H, Albertsen, B K, Wehner, P S, Callesen, M T, Kanerva, J, Frandsen, T L, Als-Nielsen, B, Hjalgrim, L L & Schmiegelow, K 2021, ' Increments in DNA-thioguanine level during thiopurine-enhanced maintenance therapy of acute lymphoblastic leukemia ', Haematologica, vol. 106, no. 11, pp. 2824-2833 . https://doi.org/10.3324/haematol.2020.278166
Haematologica
Larsen, R H, Utke Rank, C, Grell, K, Nørgaard Møller, L, Malthe Overgaard, U, Kampmann, P, Nersting, J, Degn, M, Nygaard Nielsen, S, Holst, H, Klug Albertsen, B, Skov Wehner, P, Thude Callesen, M, Kanerva, J, Leth Frandsen, T, Als-Nielsen, B, Lyngsie Hjalgrim, L & Schmiegelow, K 2021, ' Increments in DNA-thioguanine level during thiopurine enhanced maintenance therapy of acute lymphoblastic leukemia ', Haematologica, vol. 106, no. 11 . https://doi.org/10.3324/haematol.2020.278166
aintenance therapy containing methotrexate and 6-mercapto-purine is essential to cure acute lymphoblastic leukemia (ALL). Cytotoxicity is elicited by incorporation of thioguanine nucleotides into DNA (DNA-TG), and higher leukocyte DNA-TG is associate
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::02df15f6cb2dc222fe91b103108e1623
https://findresearcher.sdu.dk:8443/ws/files/194473342/10284_Article_Text_75586_2_10_20211026.pdf
https://findresearcher.sdu.dk:8443/ws/files/194473342/10284_Article_Text_75586_2_10_20211026.pdf
