Influenza A virus targets a cGAS-independent STING pathway that controls enveloped RNA viruses

Autor: Christian K. Holm, Stine H. Rahbek, Hans Henrik Gad, Rasmus O. Bak, Martin R. Jakobsen, Zhaozaho Jiang, Anne Louise Hansen, Simon K. Jensen, Chenglong Sun, Martin K. Thomsen, Anders Laustsen, Camilla G. Nielsen, Kasper Severinsen, Yingluo Xiong, Dara L. Burdette, Veit Hornung, Robert Jan Lebbink, Mogens Duch, Katherine A. Fitzgerald, Shervin Bahrami, Jakob Giehm Mikkelsen, Rune Hartmann, Søren R. Paludan

Publikováno v: Nature Communications, Vol 7, Iss 1, Pp 1-9 (2016)

Stimulator of interferon genes (STING) is known to be involved in defence against DNA viruses, but its role in the control of RNA viruses remains poorly explored. Here the authors show that STING participates in an innate immune response to RNA virus

Externí odkaz: https://doaj.org/article/00f2e460d4a44590a591e3a422a9f087

Defects in LC3B2 and ATG4A underlie HSV2 meningitis and reveal a critical role for autophagy in antiviral defense in humans

Autor: Søren R. Paludan, Alon Schneider Hait, Sathya Darmalinggam, Mette Christiansen, Simon Muller Larsen, Jørgen Kjems, Darshana D. Kadekar, Kristina Eriksson, Serge Mostowy, Liviu Ionut Moldovan, Nanna-Sophie Brinck Andersen, Vanessa Sancho-Shimizu, Trine H. Mogensen, Lasse Sommer Kristensen, Isobel Parkes, David Olagnier, Marie Helleberg, Demi van der Horst, Michelle M. Thomsen, Mette Ratzer Freytag, Kristian Alsbjerg Skipper, Stine H. Rahbek, Jacob Giehm Mikkelsen, Christian Brandt, Chiranjeevi Bodda, Fanghui Ren

Publikováno v: Hait, A S, Olagnier, D, Sancho-Shimizu, V, Skipper, K A, Helleberg, M, Larsen, S M, Bodda, C, Moldovan, L I, Ren, F, Brinck Andersen, N-S, Thomsen, M M, Freytag, M R, Darmalinggam, S, Parkes, I, Kadekar, D D, Rahbek, S H, van der Horst, D, Kristensen, L S, Eriksson, K, Kjems, J, Mostowy, S, Christiansen, M, Mikkelsen, J G, Brandt, C T, Paludan, S R & Mogensen, T H 2020, ' Defects in LC3B2 and ATG4A underlie HSV2 meningitis and reveal a critical role for autophagy in antiviral defense in humans ', Science Immunology, vol. 5, no. 54, eabc2691 . https://doi.org/10.1126/sciimmunol.abc2691
Hait, A S, Olagnier, D, Sancho-Shimizu, V, Skipper, K A, Helleberg, M, Larsen, S M, Bodda, C, Moldovan, L I, Ren, F, Andersen, N S B, Thomsen, M M, Freytag, M R, Darmalinggam, S, Parkes, I, Kadekar, D D, Rahbek, S H, van der Horst, D, Kristensen, L S, Eriksson, K, Kjems, J, Mostowy, S, Christiansen, M, Mikkelsen, J G, Brandt, C T, Paludan, S R & Mogensen, T H 2021, ' Defects in LC3B2 and ATG4A underlie HSV2 meningitis and reveal a critical role for autophagy in antiviral defense in humans ', Science immunology, vol. 5, no. 54, eabc2691 . https://doi.org/10.1126/SCIIMMUNOL.ABC2691
Science Immunology

Recurrent herpesvirus infections can manifest in different forms of disease, including cold sores, genital herpes, and encephalitis. There is an incomplete understanding of the genetic and immunological factors conferring susceptibility to recurrent

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::76e2d27ad827935f3a3c72318f2fa311
https://pure.au.dk/portal/da/publications/defects-in-lc3b2-and-atg4a-underlie-hsv2-meningitis-and-reveal-a-critical-role-for-autophagy-in-antiviral-defense-in-humans(660e28c6-e88f-4155-8813-69748e66d63d).html

Influenza A virus targets a cGAS-independent STING pathway that controls enveloped RNA viruses

Autor: Jakob Giehm Mikkelsen, Dara Burdette, Martin K. Thomsen, Kasper Severinsen, Mogens Duch, Hans Henrik Gad, Anders Laustsen, Martin R. Jakobsen, Robert Jan Lebbink, Chenglong Sun, Camilla G. Nielsen, Zhaozaho Jiang, Katherine A. Fitzgerald, Anne Louise Hansen, Rasmus O. Bak, Stine H. Rahbek, Yingluo Xiong, Søren R. Paludan, Shervin Bahrami, Rune Hartmann, Veit Hornung, Simon K. Jensen, Christian K. Holm

Publikováno v: Nature Communications, Vol 7, Iss 1, Pp 1-9 (2016)
Nature Communications
Holm, C K, Rahbek, S H, Gad, H H, Bak, R O, Jakobsen, M R, Jiang, Z, Hansen, A L, Jensen, S K, Sun, C, Thomsen, M K, Laustsen, A, Nielsen, C G, Severinsen, K, Xiong, Y, Burdette, D L, Hornung, V, Lebbink, R J, Duch, M, Fitzgerald, K A, Bahrami, S, Mikkelsen, J G, Hartmann, R & Paludan, S R 2016, ' Influenza A virus targets a cGAS-independent STING pathway that controls enveloped RNA viruses ', Nature Communications, vol. 7, 10680 . https://doi.org/10.1038/ncomms10680
Nature Communications [E], 7. Nature Publishing Group

Stimulator of interferon genes (STING) is known be involved in control of DNA viruses but has an unexplored role in control of RNA viruses. During infection with DNA viruses STING is activated downstream of cGAMP synthase (cGAS) to induce type I inte

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7a72d1a69772d92aeae8e805274e4553
https://doi.org/10.1038/ncomms10680

HSV Infection Induces Production of ROS, which Potentiate Signaling from Pattern Recognition Receptors: Role for S-glutathionylation of TRAF3 and 6

Autor: Zhijian J. Chen, Søren R. Paludan, Regina Gonzalez-Dosal, John J. Mieyal, Rune Hartmann, Kristy A. Horan, Hidenori Ichijo, Stine H. Rahbek

Publikováno v: Dosal, R G, Horan, K A, Rahbek, S H, Ichijo, H, Chen, Z J, Mieyal, J J, Hartmann, R & Paludan, S R 2011, ' HSV infection induces production of ROS, which potentiate signaling from pattern recognition receptors: role for S-glutathionylation of TRAF3 and 6 ', P L o S Pathogens, vol. 7, no. 9, pp. e1002250 . https://doi.org/10.1371/journal.ppat.1002250
PLoS Pathogens, Vol 7, Iss 9, p e1002250 (2011)
PLoS Pathogens

The innate immune response constitutes the first line of defense against infections. Pattern recognition receptors recognize pathogen structures and trigger intracellular signaling pathways leading to cytokine and chemokine expression. Reactive oxyge

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::830356d230ba70822215f39efb97cdb8
https://doi.org/10.1371/journal.ppat.1002250