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Autor:
Noor Kelawi, Maria Pedersen, Mona Pedersen, Salli Nielsen, Louise N Hansen, Faidra Voukia, Jacob Kongsted, Carsten Uhd Nielsen, Brian N Andersen, Brian Urlund, Poul Nielsen, Peter Reinholdt, Stine H Sørensen, Janne Kudsk Klitgaard, Christoffer V Heidtmann
Publikováno v:
Heidtmann, C V, Voukia, F, Hansen, L N, Sørensen, S H, Urlund, B, Nielsen, S, Pedersen, M, Kelawi, N, Andersen, B N, Pedersen, M, Reinholdt, P, Kongsted, J, Nielsen, C U, Klitgaard, J K & Nielsen, P 2020, ' Discovery of a Potent Adenine-Benzyltriazolo-Pleuromutilin Conjugate with Pronounced Antibacterial Activity against MRSA ', Journal of Medicinal Chemistry, vol. 63, no. 24, pp. 15693-15708 . https://doi.org/10.1021/acs.jmedchem.0c01328
Conjugation of pleuromutilin is an attractive strategy for the development of novel antibiotics and the fight against multiresistant bacteria as the class is associated with low rates of resistance and cross-resistance development. Herein, the prepar