Zobrazeno 1 - 10
of 35
pro vyhledávání: '"Stine Falsig Pedersen"'
Autor:
Raul Araya-Secchi, Katrine Bugge, Pernille Seiffert, Amalie Petry, Gitte W Haxholm, Kresten Lindorff-Larsen, Stine Falsig Pedersen, Lise Arleth, Birthe B Kragelund
Publikováno v:
eLife, Vol 12 (2023)
Class 1 cytokine receptors transmit signals through the membrane by a single transmembrane helix to an intrinsically disordered cytoplasmic domain that lacks kinase activity. While specific binding to phosphoinositides has been reported for the prola
Externí odkaz:
https://doaj.org/article/dfbd0e7ab7e54119a7d5a8fe4a1c6660
Autor:
Julie Schnipper, Sana Kouba, Frédéric Hague, Alban Girault, Marie-Sophie Telliez, Stéphanie Guénin, Ahmed Ahidouch, Stine Falsig Pedersen, Halima Ouadid-Ahidouch
Publikováno v:
Cancers, Vol 14, Iss 19, p 4946 (2022)
Pancreatic ductal adenocarcinoma (PDAC) remains one of the most lethal malignancies, with a low overall survival rate of less than 10% and limited therapeutic options. Fluctuations in tumor microenvironment pH are a hallmark of PDAC development and p
Externí odkaz:
https://doaj.org/article/dd23c6617c024c0a9b0f75d5cc2d6b17
Autor:
Julie Schnipper, Sana Kouba, Frédéric Hague, Alban Girault, Pierre Rybarczyk, Marie-Sophie Telliez, Stéphanie Guénin, Riad Tebbakha, Henri Sevestre, Ahmed Ahidouch, Stine Falsig Pedersen, Halima Ouadid-Ahidouch
Publikováno v:
International Journal of Molecular Sciences, Vol 23, Iss 14, p 7923 (2022)
Dysregulation of the transient receptor canonical ion channel (TRPC1) has been found in several cancer types, yet the underlying molecular mechanisms through which TRPC1 impacts pancreatic ductal adenocarcinoma (PDAC) cell proliferation are incomplet
Externí odkaz:
https://doaj.org/article/51597b621c1c4cb897885542fed1f27c
Autor:
Lise M Sjøgaard-Frich, Andreas Prestel, Emilie S Pedersen, Marc Severin, Kristian Kølby Kristensen, Johan G Olsen, Birthe B Kragelund, Stine Falsig Pedersen
Publikováno v:
eLife, Vol 10 (2021)
Calmodulin (CaM) engages in Ca2+-dependent interactions with numerous proteins, including a still incompletely understood physical and functional interaction with the human Na+/H+-exchanger NHE1. Using nuclear magnetic resonance (NMR) spectroscopy, i
Externí odkaz:
https://doaj.org/article/8fa94761a445436db31f06400ba914f9
Autor:
Sofia Avnet, Nicola Baldini, Lucie Brisson, Stine Falsig Pedersen, Paolo E. Porporato, Pierre Sonveaux, Gyorgy Szabadkai, Silvia Pastorekova
Publikováno v:
Frontiers in Oncology, Vol 9 (2019)
The metabolism of cancer cells differs from that of their normal counterparts in a spectrum of attributes, including imbalances in diverse metabolic arms and pathways, metabolic plasticity and extent of adaptive responses, levels, and activities of m
Externí odkaz:
https://doaj.org/article/7b0c127d9cb0495a976802e704875ddd
Autor:
Christina Wilkens Olesen, Jens Vogensen, Ida Axholm, Marc Severin, Julie Schnipper, Isabella Skandorff Pedersen, Jakob Hjorth von Stemann, Jacob Morville Schrøder, Dan Ploug Christensen, Stine Falsig Pedersen
Publikováno v:
Scientific Reports, Vol 8, Iss 1, Pp 1-16 (2018)
Abstract The Na+;HCO3− co-transporter NBCn1 (SLC4A7) is a major regulator of intracellular pH yet its trafficking and turnover are essentially unstudied. Here, we used MDCK-II and MCF-7 cells to investigate these processes in epithelial cells. GFP-
Externí odkaz:
https://doaj.org/article/88514809b5334da8bc2989f2186a830f
Autor:
Adélaïde Doray, Roxane Lemoine, Marc Severin, Stéphanie Chadet, Osbaldo Lopez-Charcas, Audrey Héraud, Christophe Baron, Pierre Besson, Arnaud Monteil, Stine Falsig Pedersen, Sébastien Roger
Publikováno v:
Cells, Vol 10, Iss 7, p 1624 (2021)
The SCN4B gene, coding for the NaVβ4 subunit of voltage-gated sodium channels, was recently found to be expressed in normal epithelial cells and down-regulated in several cancers. However, its function in normal epithelial cells has not been charact
Externí odkaz:
https://doaj.org/article/06e6f870a2d74cdba520fb71bbbadb45
Publikováno v:
PLoS ONE, Vol 14, Iss 8, p e0221103 (2019)
Ischemic stroke has been shown to induce breakdown of the blood-brain barrier, although these changes are not fully characterized. Oxygen-glucose deprivation (OGD) has been used to investigate the effects of ischemia in cultured brain capillary endot
Externí odkaz:
https://doaj.org/article/e38cfb01403d4ff2a104a97aef44083b
Autor:
Jiayi Yao, Dominika Czaplinska, Renata Ialchina, Julie Schnipper, Bin Liu, Albin Sandelin, Stine Falsig Pedersen
Publikováno v:
Cancers, Vol 12, Iss 8, p 2183 (2020)
The acidic pH of the tumor microenvironment plays a critical role in driving cancer development toward a more aggressive phenotype, but the underlying mechanisms are unclear. To this end, phenotypic and genotypic changes induced by adaptation of canc
Externí odkaz:
https://doaj.org/article/6454e75898e54ca1919579507ece2536
Autor:
Mette Flinck, Sofie Hagelund, Andrej Gorbatenko, Marc Severin, Elena Pedraz-Cuesta, Ivana Novak, Christian Stock, Stine Falsig Pedersen
Publikováno v:
Cells, Vol 9, Iss 2, p 465 (2020)
Increased metabolic acid production and upregulation of net acid extrusion render pH homeostasis profoundly dysregulated in many cancers. Plasma membrane activity of vacuolar H+ ATPases (V-ATPases) has been implicated in acid extrusion and invasivene
Externí odkaz:
https://doaj.org/article/3f069b3cd9134730a7e12715e3ff9504