Výsledky vyhledávání - "Stina L. Wickström"

Akademický článek

Generation of Tumor-Specific Cytotoxic T Cells From Blood via In Vitro Expansion Using Autologous Dendritic Cells Pulsed With Neoantigen-Coupled Microbeads

Autor: Adela Kiessling, Keerthana Ramanathan, Ola B. Nilsson, Luigi Notari, Stefanie Renken, Rolf Kiessling, Hans Grönlund, Stina L. Wickström

Publikováno v: Frontiers in Oncology, Vol 12 (2022)

For the past decade, adoptive cell therapy including tumor-infiltrating lymphocytes, genetically modified cytotoxic lymphocytes expressing a chimeric antigen receptor, or a novel T-cell receptor has revolutionized the treatment of many cancers. Progr

Externí odkaz: https://doaj.org/article/180142d7736a41b9b9a4d5ba34bef933

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Akademický článek

Interleukin‐33 is a Novel Immunosuppressor that Protects Cancer Cells from TIL Killing by a Macrophage‐Mediated Shedding Mechanism

Autor: Jing Wu, Ziqing Chen, Stina L. Wickström, Juan Gao, Xingkang He, Xu Jing, Jieyu Wu, Qiqiao Du, Muyi Yang, Yi Chen, Dingding Zhang, Xin Yin, Ziheng Guo, Lasse Jensen, Yunlong Yang, Wei Tao, Andreas Lundqvist, Rolf Kiessling, Yihai Cao

Publikováno v: Advanced Science, Vol 8, Iss 21, Pp n/a-n/a (2021)

Abstract Recognition of specific antigens expressed in cancer cells is the initial process of cytolytic T cell‐mediated cancer killing. However, this process can be affected by other non‐cancerous cellular components in the tumor microenvironment

Externí odkaz: https://doaj.org/article/5acdff6a3a9647a482639953692ca695

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Akademický článek

Cancer Neoepitopes for Immunotherapy: Discordance Between Tumor-Infiltrating T Cell Reactivity and Tumor MHC Peptidome Display

Autor: Stina L. Wickström, Tanja Lövgren, Michael Volkmar, Bruce Reinhold, Jonathan S. Duke-Cohan, Laura Hartmann, Janina Rebmann, Anja Mueller, Jeroen Melief, Roeltje Maas, Maarten Ligtenberg, Johan Hansson, Rienk Offringa, Barbara Seliger, Isabel Poschke, Ellis L. Reinherz, Rolf Kiessling

Publikováno v: Frontiers in Immunology, Vol 10 (2019)

Tumor-infiltrating lymphocytes (TIL) are considered enriched for T cells recognizing shared tumor antigens or mutation-derived neoepitopes. We performed exome sequencing and HLA-A*02:01 epitope prediction from tumor cell lines from two HLA-A2-positiv

Externí odkaz: https://doaj.org/article/a5d47d16c7624e0ba14d133d06de16b3

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Akademický článek

Regulatory T Cells Inhibit T Cell Activity by Downregulating CD137 Ligand via CD137 Trogocytosis

Autor: Khang Luu, Mugdha Vijay Patwardhan, Qun Zeng, Stina L. Wickström, Andreas Lundqvist, Herbert Schwarz

Publikováno v: Cells, Vol 10, Iss 2, p 353 (2021)

CD137 is a costimulatory molecule expressed on activated T cells. CD137 ligand (CD137L) is expressed by antigen presenting cells (APC), which use the CD137—CD137L system to enhance immune responses. It was, therefore, surprising to discover CD137 e

Externí odkaz: https://doaj.org/article/580f4242343e4da886b6e031fe0e49d1

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