Zobrazeno 1 - 10
of 1 430
pro vyhledávání: '"Stimulator of interferon genes"'
Publikováno v:
Medical Review, Vol 4, Iss 5, Pp 435-451 (2024)
The cyclic GMP-AMP synthase (cGAS)-stimulator of interferon genes (STING) pathway is an evolving DNA-sensing mechanism involved in innate immunity and pathogen defense that has been optimized while remaining conserved. Aside from recognizing pathogen
Externí odkaz:
https://doaj.org/article/fb8c3ec7ff8647afb8e315b114ea9b45
Autor:
Ryo Kanoda, Shotaro Nakajima, Satoshi Fukai, Motonobu Saito, Katsuharu Saito, Hiroya Suzuki, Tomohiro Kikuchi, Azuma Nirei, Hirokazu Okayama, Kosaku Mimura, Hiroyuki Hanayama, Wataru Sakamoto, Tomoyuki Momma, Zenichiro Saze, Koji Kono
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-9 (2024)
Abstract Mismatch repair deficient (dMMR)/microsatellite instability-high (MSI-H) gastric cancer (GC) exhibits an immune-active tumor microenvironment (TME) compared to MMR proficient (pMMR)/microsatellite stable/Epstein-Barr virus-negative [EBV (−
Externí odkaz:
https://doaj.org/article/57decaa1a5db4788a29f6759405f3d95
Autor:
Keyu Li, Junke Wang, Rui Zhang, Jiawei Zhou, Birginia Espinoza, Nan Niu, Jianxin Wang, Noelle Jurcak, Noah Rozich, Arsen Osipov, MacKenzie Henderson, Vanessa Funes, Melissa Lyman, Alex B. Blair, Brian Herbst, Mengni He, Jialong Yuan, Diego Trafton, Chunhui Yuan, Michael Wichroski, Xubao Liu, Juan Fu, Lei Zheng
Publikováno v:
Journal of Hematology & Oncology, Vol 17, Iss 1, Pp 1-6 (2024)
Abstract Due to the challenge for intratumoral administration, innate agonists have not made it beyond preclinical studies for efficacy testing in most tumor types. Pancreatic ductal adenocarcinoma (PDAC) has a hostile tumor microenvironment that ren
Externí odkaz:
https://doaj.org/article/bfd08d1266be4922922c25e98fb0b353
Publikováno v:
Biomarker Research, Vol 12, Iss 1, Pp 1-18 (2024)
Abstract Background Pyroptosis belongs to a unique type of programmed cell death among which GSDME is reported to exert anti-tumor immunity. However, the underlying mechanisms of how to boost tumor-infiltrating lymphocytes and whether it could benefi
Externí odkaz:
https://doaj.org/article/088e64b85cdd483d9d6ec043a6d24ab7
Autor:
Junyang Liu, Weijia Zhao, Jie Guo, Kaiwen Kang, Hua Li, Xiaohang Yang, Jie Li, Qiang Wang, Haifa Qiao
Publikováno v:
Brain Research Bulletin, Vol 216, Iss , Pp 111036- (2024)
Amyotrophic lateral sclerosis (ALS) is a fatal neurological disease characterized by the progressive destruction of the neuromuscular junction (NMJ) and the degeneration of motor neurons, eventually leading to atrophy and paralysis of voluntary muscl
Externí odkaz:
https://doaj.org/article/cf790683d52a4de8a38e31609703c803
Autor:
Yimin Yang, Xuling Luo, Yaling Wang, Aibo Xu, Lina Peng, Xiaoting Zhang, Zhen Wang, Youmin Ying, Kaiqiang Li
Publikováno v:
Biomedicine & Pharmacotherapy, Vol 177, Iss , Pp 117074- (2024)
Glioma, a common and highly malignant central nervous system tumor, markedly influences patient prognosis via interactions with glioma-associated macrophages. Previous research has revealed the anticancer potential of β-mangostin, a xanthone derivat
Externí odkaz:
https://doaj.org/article/7cc73f79db0b4a4eb6d5bb14e61ed7f6
Autor:
Fei Chang, Camilla Gunderstofte, Nicole Colussi, Mareena Pitts, Sonia R. Salvatore, Anne L. Thielke, Lucia Turell, Beatriz Alvarez, Raphaela Goldbach-Mansky, Luis Villacorta, Christian K. Holm, Francisco J. Schopfer, Anne Louise Hansen
Publikováno v:
Redox Biology, Vol 74, Iss , Pp 103202- (2024)
Stimulator of Interferon Genes (STING) is essential for the inflammatory response to cytosolic DNA. Despite that aberrant activation of STING is linked to an increasing number of inflammatory diseases, the development of inhibitors has been challengi
Externí odkaz:
https://doaj.org/article/cf3a9eefd90d46eca97eb23c61fe9d7d
Autor:
Jinyong Wang, Fang Xie, Xin Jia, Xuejiao Wang, Lingdong Kong, Yiying Li, Xue Liang, Meiqi Zhang, Yuting He, Wandi Feng, Tong Luo, Yao Wang, Anlong Xu
Publikováno v:
Journal of Pharmaceutical Analysis, Vol 14, Iss 6, Pp 100972- (2024)
The stimulator of interferon genes (STING), an integral adaptor protein in the DNA-sensing pathway, plays a pivotal role in the innate immune response against infections. Additionally, it presents a valuable therapeutic target for infectious diseases
Externí odkaz:
https://doaj.org/article/5e69b58b7f6a4f7bab4ebf696321d452
Publikováno v:
Pediatric Rheumatology Online Journal, Vol 22, Iss 1, Pp 1-6 (2024)
Abstract Background STING-associated vasculopathy with onset in infancy (SAVI) is a rare type I interferonopathy caused by heterozygous variants in the STING gene. In SAVI, STING variants confer a gain-of-function which causes overactivation of type
Externí odkaz:
https://doaj.org/article/9c3ece32fb244e11b0b443255eef6753
Autor:
Kathy Triantafilou, Barbara Szomolay, Mark William Shepherd, Joshi Ramanjulu, Martha Triantafilou
Publikováno v:
Viruses, Vol 16, Iss 10, p 1541 (2024)
Some respiratory viruses, such as Human Rhinovirus, SARS-CoV-2, and Enterovirus D-68 (EV-D68), share the feature of hijacking host lipids in order to generate specialised replication organelles (ROs) with unique lipid compositions to enable viral rep
Externí odkaz:
https://doaj.org/article/7039d9d505154e7d85746a10018003ee