Zobrazeno 1 - 10
of 6 201
pro vyhledávání: '"Stim1"'
Publikováno v:
Biomedical Technology, Vol 7, Iss , Pp 15-24 (2024)
This study aims to explore the changes in the vitreous proteomics of form deprivation myopia (FDM) in guinea pigs, in order to reveal the molecular mechanisms involved in the onset and development of myopia. The myopia model in guinea pigs was succes
Externí odkaz:
https://doaj.org/article/acd90d21a2874bc1a1f5609fc373db77
Autor:
Ran Ren, Yu Chen, Yu Zhou, Luyao Shen, Yang Chen, Juan Lei, Jingchun Wang, Xudong Liu, Nan Zhang, Dongqin Zhou, Huakan Zhao, Yongsheng Li
Publikováno v:
Genes and Diseases, Vol 11, Iss 6, Pp 101281- (2024)
Dysregulated calcium (Ca2+) signaling pathways are associated with tumor cell death and drug resistance. In non-excitable cells, such as hepatocellular carcinoma (HCC) cells, the primary pathway for Ca2+ influx is through stromal interaction molecule
Externí odkaz:
https://doaj.org/article/55338671db03450bb0bf40d337b450ab
Autor:
Hongkai Zhu, Xueqin Ruan, Kexin Zhao, Wenyong Kuang, Sufang Liu, Wenzhe Yan, Xianming Fu, Zhao Cheng, Ruijuan Li, Hongling Peng
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-13 (2024)
Abstract Immune thrombocytopenia (ITP) is an autoimmune disease caused by T-cell dysfunction. Recently, several studies have shown that a disturbed Th17/Treg balance contributes to the development of ITP. MicroRNAs (miRNAs) are small noncoding RNA mo
Externí odkaz:
https://doaj.org/article/8b93757099d041abaf1df398b05d307b
Autor:
Alvaro Macias‐Diaz, Jose J. Lopez, Maria Bravo, Isaac Jardín, Waldo Luis Garcia‐Jimenez, Francisco J. Blanco‐Blanco, Rosario Cerrato, Juan A. Rosado
Publikováno v:
Molecular Oncology, Vol 18, Iss 5, Pp 1123-1142 (2024)
Store‐operated Ca2+ entry (SOCE) is a major mechanism for Ca2+ influx in colorectal cancer (CRC) cells. This mechanism, regulated by the filling state of the intracellular Ca2+ stores, is mediated by the endoplasmic reticulum Ca2+ sensors of the st
Externí odkaz:
https://doaj.org/article/179a8bffce7e472f9c68aed715e7a97e
Autor:
Evangelia Pantazaka, Saad Alkahtani, Saud Alarifi, Abdullah A. Alkahtane, Christos Stournaras, Galatea Kallergi
Publikováno v:
Saudi Pharmaceutical Journal, Vol 32, Iss 7, Pp 102109- (2024)
KDM2B, a histone lysine demethylase, is expressed in a plethora of cancers. Earlier studies from our group, have showcased that overexpression of KDM2B in the human prostate cancer cell line DU-145 is associated with cell adhesion, actin reorganizati
Externí odkaz:
https://doaj.org/article/2263f8266dc440a09d3de8b8d363e5e4
Autor:
Dina Sweed, Sara Mohamed Abd Elhamed, Hayam Abdel Samie Aiad, Nermine Ahmed Ehsan, Aiat Shaban Hemida, Marwa Mohammed Dawoud
Publikováno v:
World Journal of Surgical Oncology, Vol 22, Iss 1, Pp 1-11 (2024)
Abstract Pancreatic ductal adenocarcinoma (PDAC) and ampullary carcinoma (AAC) are lethal malignancies with modest benefits from surgery. SOX2 and STIM1 have been linked to anticancer activity in several human malignancies. This study included 94 tum
Externí odkaz:
https://doaj.org/article/fb01ceb0f9c248fcab92dc365d3c3554
Autor:
Laura Pérez-Guàrdia, Emma Lafabrie, Nadège Diedhiou, Coralie Spiegelhalter, Jocelyn Laporte, Johann Böhm
Publikováno v:
Cells, Vol 13, Iss 22, p 1829 (2024)
Store-operated Ca2+ entry (SOCE) controls Ca2+ homeostasis and mediates multiple Ca2+-dependent signaling pathways and cellular processes. It relies on the concerted activity of the reticular Ca2+ sensor STIM1 and the plasma membrane Ca2+ channel ORA
Externí odkaz:
https://doaj.org/article/433bc148b6a54aa5a066d77dc9c3a24e
Publikováno v:
Frontiers in Molecular Neuroscience, Vol 17 (2024)
This investigation aims to elucidate the novel role of Stromal Interaction Molecule 1 (STIM1) in modulating store-operated calcium entry (SOCE) and its subsequent impact on inflammatory cytokine release in T lymphocytes, thereby advancing our underst
Externí odkaz:
https://doaj.org/article/0049697cec9e46148f5c1d43d1a84a5e
Autor:
Argyro Roumeliotou, Saad Alkahtani, Saud Alarifi, Abdullah A. Alkahtane, Christos Stournaras, Galatea Kallergi
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 12 (2024)
Introduction: Previous publications have shown that STIM1, ORAI1, and KDM2B, are implicated in Ca2+ signaling and are highly expressed in various cancer subtypes including prostate cancer. They play multiple roles in cancer cell migration, invasion,
Externí odkaz:
https://doaj.org/article/bfd05c6fc649446f8deb076ffea8be88
Autor:
Christos Dogrammatzis, Rabina Saud, Hope Waisner, Sarah Lasnier, Sreenath Muraleedharan Suma, Brandon Grieshaber, Maria Kalamvoki
Publikováno v:
mBio, Vol 15, Iss 4 (2024)
ABSTRACTThe STimulator of INterferon Genes (STING) constitutes a major DNA-sensing pathway that restricts HSV-1 infection in different models by activating type I interferon and pro-inflammatory responses. To counteract STING, HSV-1 has evolved numer
Externí odkaz:
https://doaj.org/article/57b7d77f725c4f549cbb5d17428610fc