Zobrazeno 1 - 10
of 25
pro vyhledávání: '"Stijn M. Agten"'
Autor:
Tianyu Yao, Honglin Chen, Rong Wang, Rebeca Rivero, Fengyu Wang, Lilian Kessels, Stijn M. Agten, Tilman M. Hackeng, Tim G.A.M. Wolfs, Daidi Fan, Matthew B. Baker, Lorenzo Moroni
Publikováno v:
Bioactive Materials, Vol 20, Iss , Pp 306-317 (2023)
Vascular endothelial growth factor (VEGF) plays a vital role in promoting attachment and proliferation of endothelial cells, and induces angiogenesis. In recent years, much research has been conducted on the functionalization of tissue engineering sc
Externí odkaz:
https://doaj.org/article/eb63cbeba182423bbe382a58940a4a3a
Autor:
Johana Hrdinova, Delia I. Fernández, Bogac Ercig, Bibian M. E. Tullemans, Dennis P. L. Suylen, Stijn M. Agten, Kerstin Jurk, Tilman M. Hackeng, Karen Vanhoorelbeke, Jan Voorberg, Chris P. M. Reutelingsperger, Kanin Wichapong, Johan W. M. Heemskerk, Gerry A. F. Nicolaes
Publikováno v:
International Journal of Molecular Sciences, Vol 23, Iss 4, p 2046 (2022)
The plasmatic von Willebrand factor (VWF) circulates in a compact form unable to bind platelets. Upon shear stress, the VWF A1 domain is exposed, allowing VWF-binding to platelet glycoprotein Ib-V-IX (GPIbα chain). For a better understanding of the
Externí odkaz:
https://doaj.org/article/bfd5fd8e5b1a4dd094dda91b6eb02d30
Autor:
Julian Leberzammer, Stijn M. Agten, Xavier Blanchet, Rundan Duan, Hans Ippel, Remco T. A. Megens, Christian Schulz, Maria Aslani, Johan Duchene, Yvonne Döring, Natalie J. Jooss, Pengyu Zhang, Richard Brandl, Konstantin Stark, Wolfgang Siess, Kerstin Jurk, Johan W. M. Heemskerk, Tilman M. Hackeng, Kevin H. Mayo, Christian Weber, Philipp von Hundelshausen
Publikováno v:
Blood, 139(17), 2691-2705. The American Society of Hematology
Leberzammer, Julian; Agten, Stijn M; Blanchet, Xavier; Duan, Rundan; Ippel, Hans; Megens, Remco T A; Schulz, Christian; Aslani, Maria; Duchene, Johan; Döring, Yvonne; Jooss, Natalie Jasmin; Zhang, Pengyu; Brandl, Richard; Stark, Konstantin; Siess, Wolfgang; Jurk, Kerstin; Heemskerk, Johan W M; Hackeng, Tilman M; Mayo, Kevin H; Weber, Christian; ... (2022). Targeting platelet-derived CXCL12 impedes arterial thrombosis. Blood, 139(17), pp. 2691-2705. American Society of Hematology 10.1182/blood.2020010140
Leberzammer, Julian; Agten, Stijn M; Blanchet, Xavier; Duan, Rundan; Ippel, Hans; Megens, Remco T A; Schulz, Christian; Aslani, Maria; Duchene, Johan; Döring, Yvonne; Jooss, Natalie Jasmin; Zhang, Pengyu; Brandl, Richard; Stark, Konstantin; Siess, Wolfgang; Jurk, Kerstin; Heemskerk, Johan W M; Hackeng, Tilman M; Mayo, Kevin H; Weber, Christian; ... (2022). Targeting platelet-derived CXCL12 impedes arterial thrombosis. Blood, 139(17), pp. 2691-2705. American Society of Hematology 10.1182/blood.2020010140
The prevention and treatment of arterial thrombosis continue to be clinically challenging, and understanding the relevant molecular mechanisms in detail may facilitate the quest to identify novel targets and therapeutic approaches that improve protec
Potent Cyclic Peptide Inhibitors of FXIIa Discovered by mRNA Display with Genetic Code Reprogramming
Autor:
Daniel J Ford, Henri M. H. Spronk, Wenyu Liu, Vishnu M. Sasi, Colin J. Jackson, Tilman M. Hackeng, Nisharnthi M Duggan, Pedro Pereira, Hiroaki Suga, Stijn M. Agten, Anneliese S. Ashhurst, Rene van Oerle, Jorge Ripoll-Rozada, Richard J. Payne, Joe A. Kaczmarski, Leo Corcilius, Toby Passioura, Sarah E. Fry
Publikováno v:
Journal of Medicinal Chemistry, 64(11), 7853-7876. American Chemical Society
The contact system comprises a series of serine proteases that mediate procoagulant and proinflammatory activities via the intrinsic pathway of coagulation and the kallikrein-kinin system, respectively. Inhibition of Factor XIIa (FXIIa), an initiator
Although anatomical imaging modalities (X-ray, computed tomography (CT), magnetic resonance imaging (MRI)) still have a higher spatial resolution (0.1–1 mm) than molecular imaging modalities (single-photon emission computed tomography (SPECT), posi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5582f4332d5ac7787668c8acbdf48e87
https://doi.org/10.5772/intechopen.99422
https://doi.org/10.5772/intechopen.99422
Autor:
Mike C. L. Wu, Imala Alwis, Richard J. Payne, Pedro Pereira, Shaun P. Jackson, Emma E. Watson, Jorge Ripoll-Rozada, Stijn M. Agten, Luke J. Dowman
Publikováno v:
Angewandte Chemie-International Edition, 60(10), 5348-5356. Wiley-VCH Verlag
Blood feeding arthropods, such as leeches, ticks, flies and mosquitoes, provide a privileged source of peptidic anticoagulant molecules. These primarily operate through inhibition of the central coagulation protease thrombin by binding to the active
Publikováno v:
Total Chemical Synthesis of Proteins
Autor:
Stijn M. Agten, Emma E. Watson, Jorge Ripoll‐Rozada, Luke J. Dowman, Mike C. L. Wu, Imala Alwis, Shaun P. Jackson, Pedro José Barbosa Pereira, Richard J. Payne
Publikováno v:
Angewandte Chemie. 133:5408-5416
Synthesis and evaluation of peptidic thrombin inhibitors bearing acid-stable sulfotyrosine analogues
Autor:
Jorge Ripoll-Rozada, Bárbara M. Calisto, Pedro Pereira, Richard J. Payne, Stijn M. Agten, Luke J. Dowman
Publikováno v:
Chemical Communications, 57(83), 10923-10926. Royal Society of Chemistry
Tyrosine sulfation is an important post-translational modification of peptides and proteins which underpins and modulates many protein-protein interactions. In order to overcome the inherent instability of the native modification, we report the synth
Autor:
Sophie C. Dólleman, Stijn M. Agten, Henri M.H. Spronk, Tilman M. Hackeng, Mettine H.A. Bos, Henri H. Versteeg, Anton Jan van Zonneveld, Hetty C. de Boer
Publikováno v:
Journal of Thrombosis and Haemostasis, 20(4), 996-1007. WILEY
Journal of Thrombosis and Haemostasis, 20(4), 996-1007. Wiley
Journal of Thrombosis and Haemostasis, 20(4), 996-1007. Wiley
Background Atrial fibrillation (AF) can lead to the loss of microvascular integrity thereby enhancing AF progression. Mechanistically, the pro-coagulant state that drives the risk of stroke in patients with AF may also play a causal role in microvasc