Zobrazeno 1 - 10
of 32
pro vyhledávání: '"Stijn, De Munter"'
Autor:
Tamara De Vos, Nicole Oatman, Lena Boehme, Tom Putteman, Imke Velghe, Yana Van Droogenbroeck, Stijn De Munter, Michaela Cesnekova, Filip Van Nieuwerburgh, Bart Vandekerckhove, Jan Philippe, Tom Taghon
Publikováno v:
Haematologica, Vol 999, Iss 1 (2024)
Hematopoiesis is driven by molecular mechanisms that induce differentiation and proliferation of hematopoietic stem cells and their progeny. This involves the activity of various transcription factors, such as members of the Hairy/Enhancer of Split (
Externí odkaz:
https://doaj.org/article/2ba793734fde41f4aa47b970e723784c
Autor:
Melissa Pille, John Avila, Guillem Sanchez Sanchez, Glenn Goetgeluk, Stijn De Munter, Hanne Jansen, Lore Billiet, Karin Weening, Haipeng Xue, Sarah Bonte, Joline Ingels, Laurenz De Cock, Eva Pascal, Lucas Deseins, Tessa Kerre, Tom Taghon, Georges Leclercq, David Vermijlen, Brian Davis, Bart Vandekerckhove
Publikováno v:
Frontiers in Immunology, Vol 14 (2023)
The Wiskott–Aldrich syndrome (WAS) is an X-linked primary immune deficiency caused by a mutation in the WAS gene. This leads to altered or absent WAS protein (WASp) expression and function resulting in thrombocytopenia, eczema, recurrent infections
Externí odkaz:
https://doaj.org/article/8e328ea3407848819b605b95f452cf7f
The transcription factor RUNX2 drives the generation of human NK cells and promotes tissue residency
Autor:
Sigrid Wahlen, Filip Matthijssens, Wouter Van Loocke, Sylvie Taveirne, Laura Kiekens, Eva Persyn, Els Van Ammel, Zenzi De Vos, Stijn De Munter, Patrick Matthys, Filip Van Nieuwerburgh, Tom Taghon, Bart Vandekerckhove, Pieter Van Vlierberghe, Georges Leclercq
Publikováno v:
eLife, Vol 11 (2022)
Natural killer (NK) cells are innate lymphocytes that eliminate virus-infected and cancer cells by cytotoxicity and cytokine secretion. In addition to circulating NK cells, distinct tissue-resident NK subsets have been identified in various organs. A
Externí odkaz:
https://doaj.org/article/11397126237f4caebcb161863a688e20
Autor:
Laurens Raes, Stephan Stremersch, Juan C. Fraire, Toon Brans, Glenn Goetgeluk, Stijn De Munter, Lien Van Hoecke, Rein Verbeke, Jelter Van Hoeck, Ranhua Xiong, Xavier Saelens, Bart Vandekerckhove, Stefaan De Smedt, Koen Raemdonck, Kevin Braeckmans
Publikováno v:
Nano-Micro Letters, Vol 12, Iss 1, Pp 1-17 (2020)
Abstract Efficient and safe cell engineering by transfection of nucleic acids remains one of the long-standing hurdles for fundamental biomedical research and many new therapeutic applications, such as CAR T cell-based therapies. mRNA has recently ga
Externí odkaz:
https://doaj.org/article/543a96ad06524b4f9271212ffb59401e
Autor:
Leander Huyghe, Alexander Van Parys, Anje Cauwels, Sandra Van Lint, Stijn De Munter, Jennyfer Bultinck, Lennart Zabeau, Jeroen Hostens, An Goethals, Nele Vanderroost, Annick Verhee, Gilles Uzé, Niko Kley, Frank Peelman, Bart Vandekerckhove, Peter Brouckaert, Jan Tavernier
Publikováno v:
EMBO Molecular Medicine, Vol 12, Iss 2, Pp 1-15 (2020)
Abstract Systemic toxicities have severely limited the clinical application of tumor necrosis factor (TNF) as an anticancer agent. Activity‐on‐Target cytokines (AcTakines) are a novel class of immunocytokines with improved therapeutic index. A TN
Externí odkaz:
https://doaj.org/article/0c182dbd4d474d4e99086c5f110eebd3
Autor:
Sarah Bonte, Stijn de Munter, Lore Billiet, Glenn Goetgeluk, Joline Ingels, Hanne Jansen, Melissa Pille, Laurenz de Cock, Karin Weening, Tom Taghon, Georges Leclercq, Bart Vandekerckhove, Tessa Kerre
Publikováno v:
OncoImmunology, Vol 10, Iss 1 (2021)
T cell receptor (TCR)-redirected T cells target intracellular antigens such as Wilms’ tumor 1 (WT1), a tumor-associated antigen overexpressed in several malignancies, including acute myeloid leukemia (AML). For both chimeric antigen receptor (CAR)-
Externí odkaz:
https://doaj.org/article/b8d37350b35e4c9e9ca7c2af1a96b344
Autor:
Barbara Depreter, Karin E. Weening, Karl Vandepoele, Magnus Essand, Barbara De Moerloose, Maria Themeli, Jacqueline Cloos, Diana Hanekamp, Ine Moors, Inge D’hont, Barbara Denys, Anne Uyttebroeck, An Van Damme, Laurence Dedeken, Sylvia Snauwaert, Glenn Goetgeluk, Stijn De Munter, Tessa Kerre, Bart Vandekerckhove, Tim Lammens, Jan Philippé
Publikováno v:
Haematologica, Vol 105, Iss 5 (2020)
Immunotherapeutic strategies targeting the rare leukemic stem cell compartment might provide salvage to the high relapse rates currently observed in acute myeloid leukemia (AML). We applied gene expression profiling for comparison of leukemic blasts
Externí odkaz:
https://doaj.org/article/fd108e28e0bd4466a0913f7a7117a0d5
Autor:
Sarah Bonte, Stijn De Munter, Glenn Goetgeluk, Joline Ingels, Melissa Pille, Lore Billiet, Tom Taghon, Georges Leclercq, Bart Vandekerckhove, Tessa Kerre
Publikováno v:
OncoImmunology, Vol 9, Iss 1 (2020)
Chimeric antigen receptor (CAR) T-cells have shown great promise in the treatment of B-cell malignancies. For acute myeloid leukemia (AML), however, the optimal target surface antigen has yet to be discovered. Alternatively, T-cell receptor (TCR)-red
Externí odkaz:
https://doaj.org/article/8a9e6e8dd9154340bb2f53f8c0e0027b
Autor:
Elien De Bousser, Nele Festjens, Leander Meuris, Evelyn Plets, Annelies Van Hecke, Elise Wyseure, Stijn De Munter, Bart Vandekerckhove, Nico Callewaert
Recently, chimeric antigen receptor (CAR) T cell technology has revolutionized cancer immunotherapy. This strategy uses synthetic CARs to redirect T cells to specific antigens expressed on the surface of tumor cells. Despite impressive progress in th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c7cd6aa35fc03b1b92df45467a5042d2
https://doi.org/10.1101/2023.01.23.525164
https://doi.org/10.1101/2023.01.23.525164
Autor:
Stijn De Munter, Juliane Buhl, Laurenz De Cock, Alexander Van Parys, Willem Daneels, Eva Pascal, Lucas Deseins, Joline Ingels, Glenn Goetgeluk, Lore Billiet, Melissa Pille, Niels Vandamme, Jo Van Dorpe, Fritz Offner, Erik Depla, Jan Tavernier, Tessa Kerre, Jarno Drost, Bart Vandekerckhove
CD70 is an attractive target for chimeric antigen receptor (CAR) T cell therapy as treatment for both solid and liquid malignancies. However, functionality of CD70-specific CARs is only modest. Here, we optimized a CD70-specific VHH based CAR (nanoCA
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2e90292e5574b0d0e1648efcade88f4e
https://doi.org/10.1101/2023.01.22.523482
https://doi.org/10.1101/2023.01.22.523482