Zobrazeno 1 - 10
of 13
pro vyhledávání: '"Stig Hill Christiansen"'
Autor:
Sandra M Skovdal, Stig Hill Christiansen, Karen Singers Johansen, Ole Viborg, Niels Henrik Bruun, Søren Jensen-Fangel, Ida Elisabeth Holm, Thomas Vorup-Jensen, Eskild Petersen
Publikováno v:
PLoS ONE, Vol 14, Iss 10, p e0223647 (2019)
The developmental speed of new antimicrobials does not meet the emergence of multidrug-resistant bacteria sufficiently. A potential shortcut is assessing the antimicrobial activity of already approved drugs. Intrudingly, the antibacterial action of g
Externí odkaz:
https://doaj.org/article/7d42a65bd6d94152b8ccd00ab6ec56ba
Autor:
Abirami Kugadas, Stig Hill Christiansen, Saiprasad Sankaranarayanan, Neeraj K Surana, Stefanie Gauguet, Ryan Kunz, Raina Fichorova, Thomas Vorup-Jensen, Mihaela Gadjeva
Publikováno v:
PLoS Pathogens, Vol 12, Iss 9, p e1005855 (2016)
The existence of the ocular microbiota has been reported but functional analyses to evaluate its significance in regulating ocular immunity are currently lacking. We compared the relative contribution of eye and gut commensals in regulating the ocula
Externí odkaz:
https://doaj.org/article/c7c3365bba1e4646b833a93dce6d3244
Contact activation‐induced complex formation between complement factor H and coagulation factor XIIa
Autor:
Stig Hill Christiansen, Jonas Heilskov Graversen, Yaseelan Palarasah, Sai Sindhu Thangaraj, Anette Bygum, Søren Hansen, Jørgen Gram, Johannes Jakobsen Sidelmann
Publikováno v:
Thangaraj, S S, Hill Christiansen, S, Heilskov Graversen, J, Sidelmann, J J, Hansen, S W K, Bygum, A, Gram, J B & Palarasah, Y 2020, ' Contact activation-induced complex formation between complement factor H and coagulation factor XIIa ', Journal of Thrombosis and Haemostasis .
Thangaraj, S S, Christiansen, S H, Graversen, J H, Sidelmann, J J, Hansen, S W K, Bygum, A, Gram, J B & Palarasah, Y 2020, ' Contact activation-induced complex formation between complement factor H and coagulation factor XIIa ', Journal of Thrombosis and Haemostasis, vol. 18, no. 4, pp. 876-884 . https://doi.org/10.1111/jth.14742
Thangaraj, S S, Christiansen, S H, Graversen, J H, Sidelmann, J J, Hansen, S W K, Bygum, A, Gram, J B & Palarasah, Y 2020, ' Contact activation-induced complex formation between complement factor H and coagulation factor XIIa ', Journal of Thrombosis and Haemostasis, vol. 18, no. 4, pp. 876-884 . https://doi.org/10.1111/jth.14742
BACKGROUND: The complement and coagulation systems share an evolutionary origin with many components showing structural homology. Certain components, including complement factor H (FH) and coagulation factor XII (FXII), have separately been shown to
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e1b06a6c776e99871d0282d0fb79092c
https://pure.au.dk/portal/da/publications/contact-activationinduced-complex-formation-between-complement-factor-h-and-coagulation-factor-xiia(233e7d2f-425b-4c5b-8801-c5b7608d9ab7).html
https://pure.au.dk/portal/da/publications/contact-activationinduced-complex-formation-between-complement-factor-h-and-coagulation-factor-xiia(233e7d2f-425b-4c5b-8801-c5b7608d9ab7).html
Autor:
Eskild Petersen, Ole Viborg, Thomas Vorup-Jensen, Karen Singers Eiskjær Johansen, Stig Hill Christiansen, Sandra M. Skovdal, Ida Elisabeth Holm, Niels Henrik Bruun, Søren Jensen-Fangel
Publikováno v:
Skovdal, S M, Hill Christiansen, S, Singers Johansen, K, Viborg, O, Bruun, N H, Jensen-Fangel, S, Holm, I E, Vorup-Jensen, T & Petersen, J E 2019, ' Inhaled nebulized glatiramer acetate against Gram-negative bacteria is not associated with adverse pulmonary reactions in healthy, young adult female pigs ', P L o S One, vol. 14, no. 10, e0223647 . https://doi.org/10.1371/journal.pone.0223647
PLoS ONE
Skovdal, S M, Christiansen, S H, Johansen, K S, Viborg, O, Bruun, N H, Jensen-Fangel, S, Holm, I E, Vorup-Jensen, T & Petersen, E 2019, ' Inhaled nebulized glatiramer acetate against Gram-negative bacteria is not associated with adverse pulmonary reactions in healthy, young adult female pigs ', PLOS ONE, vol. 14, no. 10, e0223647 . https://doi.org/10.1371/journal.pone.0223647
Skovdal, S M, Christiansen, S H, Johansen, K S, Viborg, O, Bruun, N H, Jensen-Fangel, S, Holm, I E, Vorup-Jensen, T & Petersen, E 2019, ' Inhaled nebulized glatiramer acetate against Gram-negative bacteria is not associated with adverse pulmonary reactions in healthy, young adult female pigs ', PLOS ONE, vol. 14, no. 10, pp. e0223647 . https://doi.org/10.1371/journal.pone.0223647
PLoS ONE, Vol 14, Iss 10, p e0223647 (2019)
PLoS ONE
Skovdal, S M, Christiansen, S H, Johansen, K S, Viborg, O, Bruun, N H, Jensen-Fangel, S, Holm, I E, Vorup-Jensen, T & Petersen, E 2019, ' Inhaled nebulized glatiramer acetate against Gram-negative bacteria is not associated with adverse pulmonary reactions in healthy, young adult female pigs ', PLOS ONE, vol. 14, no. 10, e0223647 . https://doi.org/10.1371/journal.pone.0223647
Skovdal, S M, Christiansen, S H, Johansen, K S, Viborg, O, Bruun, N H, Jensen-Fangel, S, Holm, I E, Vorup-Jensen, T & Petersen, E 2019, ' Inhaled nebulized glatiramer acetate against Gram-negative bacteria is not associated with adverse pulmonary reactions in healthy, young adult female pigs ', PLOS ONE, vol. 14, no. 10, pp. e0223647 . https://doi.org/10.1371/journal.pone.0223647
PLoS ONE, Vol 14, Iss 10, p e0223647 (2019)
The developmental speed of new antimicrobials does not meet the emergence of multidrugresistant bacteria sufficiently. A potential shortcut is assessing the antimicrobial activity of already approved drugs. Intrudingly, the antibacterial action of gl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4b083550dc64d51b458de55a19f825cd
https://findresearcher.sdu.dk:8443/ws/files/154913975/journal.pone.0223647.pdf
https://findresearcher.sdu.dk:8443/ws/files/154913975/journal.pone.0223647.pdf
Autor:
Kasper Nørskov Kragh, Niels Høiby, Priyanka Sahasrabudhe, Thomas Bjarnsholt, Helen Chadwick, Kathryn Oliver, Stig Hill Christiansen, Megan Bergkessel, Blaine Gabriel Fritz
Publikováno v:
Pediatric Pulmonology. 52:S214-S516
Autor:
Helen Chadwick, Zhongyou Li, Kathryn Oliver, Kai Hilpert, Robert Giusti, Stig Hill Christiansen, Shayan Saeed, Megan Bergkessel, Christina Jayne (CJ) Bathgate
Publikováno v:
Pediatric pulmonology. 54
The current treatment regimen for nontuberculous mycobacteria (NTM) involves long courses of antibiotic cocktails that demonstrate limited efficacy and cause frequent and serious side effects. Mycobacterium abscessus, in particular, is difficult to t
Autor:
Thomas Vorup-Jensen, Marlene Fredborg, Michael Lykke Hvam, Rikke Louise Meyer, R.A. Murphy, Mihaela Gadjeva, Jens R. Nyengaard, Arne Möller, Stig Hill Christiansen, M. Wang, Sandra M. Skovdal, Kenneth A. Howard, Eskild Petersen, Jane C. Davies, Kristian Juul-Madsen, Uffe B. Skov Sørensen, Esben Axelgaard, Niels Nørskov-Lauritsen
Publikováno v:
Hill Christiansen, S, Murphy, R A, Juul-Madsen, K, Fredborg, M, Hvam, M L, Axelgaard, E, Skovdal, S M, Meyer, R L, Sørensen, U B S, Möller, A, Nyengaard, J R, Nørskov-Lauritsen, N, Wang, M, Gadjeva, M, Howard, K A, Davies, J C, Petersen, E & Vorup-Jensen, T 2017, ' The Immunomodulatory Drug Glatiramer Acetate is Also an Effective Antimicrobial Agent that Kills Gram-negative Bacteria ', Scientific Reports, vol. 7, 15653 . https://doi.org/10.1038/s41598-017-15969-3
Christiansen, S H, Murphy, R A, Juul-Madsen, K, Fredborg, M, Hvam, M L, Axelgaard, E, Skovdal, S M, Meyer, R L, Sorensen, U B S, Moeller, A, Nyengaard, J R, Norskov-Lauritsen, N, Wang, M, Gadjeva, M, Howard, K A, Davies, J C, Petersen, E & Vorup-Jensen, T 2017, ' The Immunomodulatory Drug Glatiramer Acetate is Also an Effective Antimicrobial Agent that Kills Gram-negative Bacteria ', Scientific Reports, vol. 7, 15653 . https://doi.org/10.1038/s41598-017-15969-3
Scientific Reports, Vol 7, Iss 1, Pp 1-16 (2017)
Scientific Reports
Christiansen, S H, Murphy, R A, Juul-Madsen, K, Fredborg, M, Hvam, M L, Axelgaard, E, Skovdal, S M, Meyer, R L, Sorensen, U B S, Moeller, A, Nyengaard, J R, Norskov-Lauritsen, N, Wang, M, Gadjeva, M, Howard, K A, Davies, J C, Petersen, E & Vorup-Jensen, T 2017, ' The Immunomodulatory Drug Glatiramer Acetate is Also an Effective Antimicrobial Agent that Kills Gram-negative Bacteria ', Scientific Reports, vol. 7, 15653 . https://doi.org/10.1038/s41598-017-15969-3
Scientific Reports, Vol 7, Iss 1, Pp 1-16 (2017)
Scientific Reports
Classic drug development strategies have failed to meet the urgent clinical needs in treating infections with Gram-negative bacteria. Repurposing drugs can lead to timely availability of new antibiotics, accelerated by existing safety profiles. Glati
Autor:
Anders G. Kjærgaard, Stig Hill Christiansen, Tue Wenzel Kragstrup, Xianwei Zhang, Jan Krog, Thomas Vorup-Jensen, Kristian Juul-Madsen
Publikováno v:
Kragstrup, T W, Juul-Madsen, K, Christiansen, S H, Zhang, X, Krog, J, Vorup-Jensen, T & Kjaergaard, A G 2017, ' Altered levels of soluble CD18 may associate immune mechanisms with outcome in sepsis ', Clinical and Experimental Immunology, vol. 190, no. 2, pp. 258-267 . https://doi.org/10.1111/cei.13016
Summary The pathogenesis of sepsis involves a dual inflammatory response, with a hyperinflammatory phase followed by, or in combination with, a hypoinflammatory phase. The adhesion molecules lymphocyte function-associated antigen (LFA-1) (CD11a/CD18)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c6efb76c519ab700ab5d0201179546c0
https://europepmc.org/articles/PMC5629430/
https://europepmc.org/articles/PMC5629430/
Autor:
Kristian Juul-Madsen, Stig Hill Christiansen, Xianwei Zhang, Kenneth A. Howard, Michael Lykke Hvam, Manja A. Behrens, Jan Skov Pedersen, Babak Jalilian, Brian S. Vad, Thomas Vorup-Jensen, Ida Lysgaard Thygesen, Daniel E. Otzen
Publikováno v:
Christiansen, S H, Zhang, X, Juul-Madsen, K, Hvam, M L, Vad, B S, Behrens, M A, Thygesen, I L, Jalilian, B, Pedersen, J S, Howard, K, Otzen, D & Vorup-Jensen, T 2017, ' The random co-polymer glatiramer acetate rapidly kills primary human leukocytes through sialic-acid-dependent cell membrane damage ', Biochimica et Biophysica Acta. Biomembranes, bind 1859, s. 425–437 . https://doi.org/10.1016/j.bbamem.2017.01.001
Christiansen, S H, Zhang, X, Juul-Madsen, K, Hvam, M L, Vad, B S, Behrens, M A, Thygesen, I L, Jalilian, B, Pedersen, J S, Howard, K, Otzen, D E & Vorup-Jensen, T 2017, ' The random co-polymer glatiramer acetate rapidly kills primary human leukocytes through sialic-acid-dependent cell membrane damage ', B B A-Biomembranes, vol. 1859, no. 3, pp. 425-437 . https://doi.org/10.1016/j.bbamem.2017.01.001
Christiansen, S H, Zhang, X, Juul-Madsen, K, Hvam, M L, Vad, B S, Behrens, M A, Thygesen, I L, Jalilian, B, Pedersen, J S, Howard, K, Otzen, D E & Vorup-Jensen, T 2017, ' The random co-polymer glatiramer acetate rapidly kills primary human leukocytes through sialic-acid-dependent cell membrane damage ', B B A-Biomembranes, vol. 1859, no. 3, pp. 425-437 . https://doi.org/10.1016/j.bbamem.2017.01.001
The formulation glatiramer acetate (GA) is widely used in therapy of multiple sclerosis. GA consists of random copolymers of four amino acids, in ratios that produce a predominantly positive charge and an amphipathic character. With the extraordinary
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d32141dd5af50467d0c3af97a22cb8bc
https://orbit.dtu.dk/en/publications/682bf468-b92a-4415-8944-b550c55f5ee2
https://orbit.dtu.dk/en/publications/682bf468-b92a-4415-8944-b550c55f5ee2
Autor:
Thomas Vorup-Jensen, Mihaela Gadjeva, Stefanie Gauguet, Neeraj K. Surana, Raina N. Fichorova, Abirami Kugadas, Saiprasad Sankaranarayanan, Ryan C. Kunz, Stig Hill Christiansen
Publikováno v:
PLoS Pathogens, Vol 12, Iss 9, p e1005855 (2016)
PLoS Pathogens
PLoS Pathogens
The existence of the ocular microbiota has been reported but functional analyses to evaluate its significance in regulating ocular immunity are currently lacking. We compared the relative contribution of eye and gut commensals in regulating the ocula