Ruthenium-catalysed C‒H amidation for the late-stage synthesis of PROTACs

Autor: Daniele Antermite, Stig D. Friis, Johan R. Johansson, Okky D. Putra, Lutz Ackermann, Magnus J. Johansson

PROteolysis TArgeting Chimeras (PROTACs) are a powerful modality in drug discovery, offering the potential to address outstanding medical challenges. However, the synthetic feasibility of PROTACs, and the empiric and complex nature of their structure

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::7407f4ceba551c273af6fc4bdc96808e
https://doi.org/10.26434/chemrxiv-2023-669wc

Cobalt-catalysed C–H methylation for late-stage drug diversification

Autor: Lutz Ackermann, Stig D. Friis, Magnus Johansson

Publikováno v: Nature Chemistry. 12:511-519

The magic methyl effect is well acknowledged in medicinal chemistry, but despite its significance, accessing such analogues via derivatization at a late stage remains a pivotal challenge. In an effort to mitigate this major limitation, we here presen

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::84429afde01594ea1b06f2b0b26b6622
https://doi.org/10.1038/s41557-020-0475-7

The Power of High-Throughput Experimentation: Case Studies From Drug Discovery, Drug Development, and Catalyst Discovery (Volume 2)

Autor: Marion H. Emmert, Matthieu Jouffroy, David C. Leitch, Alexander Buitrago Santanilla, Gemma Cook, Amanda Dombrowski, Nathan Gesmundo, Dipannita Kalyani, Mycah Uehling, Michael Wleklinski, Nicole C. Goodwin, Katherine Honicker, Jonathan Latham, Katherine M. P. Wheelhouse, Sabine Fenner, Matthew P. Whiting, Chunrui Sun, Ji Qi, Feng Peng, Niki R. Patel, Danielle Schultz, Orion Staples, Jacob S. Mohar, Daniel J. Mindiola, Victoria Dimakos, Stephen G. Newman, Stig D. Friis, Erik Weis, Magnus J. Johansson

'High-throughput experimentation (HTE) is an emerging and powerful approach to problems in organic chemistry and homogeneous catalysis. This book is targeted at both experts and those new to the field who are seeking general perspectives and design p

Cobalt-catalysed C-H methylation for late-stage drug diversification

Autor: Stig D, Friis, Magnus J, Johansson, Lutz, Ackermann

Publikováno v: Nature chemistry. 12(6)

The magic methyl effect is well acknowledged in medicinal chemistry, but despite its significance, accessing such analogues via derivatization at a late stage remains a pivotal challenge. In an effort to mitigate this major limitation, we here presen

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::cee224168e73a43ddbab67604aa7ffe3
https://pubmed.ncbi.nlm.nih.gov/32472104

Intermittent, low dose carbon monoxide exposure enhances survival and dopaminergic differentiation of human neural stem cells

Autor: Jan Bert Gramsbergen, Pia Jensen, Bjarne Winther Kristensen, Troels Skrydstrup, Morten Meyer, Justyna Okarmus, Tine Rosenberg, Nanna Dreyer-Andersen, Alberto Serrano, Stig D. Friis, Helena L. A. Vieira, Ana Almeida, Morten Blaabjerg, Morad Kamand

Publikováno v: Repositório Científico de Acesso Aberto de Portugal
Repositório Científico de Acesso Aberto de Portugal (RCAAP)
instacron:RCAAP
PLoS ONE, Vol 13, Iss 1, p e0191207 (2018)
Digital.CSIC. Repositorio Institucional del CSIC
instname
PLoS ONE
PLOS ONE
Dreyer-Andersen, N, Almeida, A S, Jensen, P, Kamand, M, Okarmus, J, Rosenberg, T, Friis, S D, Martínez Serrano, A, Blaabjerg, M, Kristensen, B W, Skrydstrup, T, Gramsbergen, J B, Vieira, H L A & Meyer, M 2018, ' Intermittent, low dose carbon monoxide exposure enhances survival and dopaminergic differentiation of human neural stem cells ', PLOS ONE, vol. 13, no. 1, e0191207 . https://doi.org/10.1371/journal.pone.0191207
Dreyer-Andersen, N, Almeida, A S, Jensen, P, Kamand, M, Okarmus, J, Rosenberg, T, Friis, S D, Serrano, A M, Blaabjerg, M, Kristensen, B W, Skrydstrup, T, Gramsbergen, J B, Vieira, H L A & Meyer, M 2018, ' Intermittent, low dose carbon monoxide exposure enhances survival and dopaminergic differentiation of human neural stem cells ', P L o S One, vol. 13, no. 1, e0191207 . https://doi.org/10.1371/journal.pone.0191207
Repositorio Institucional de la Consejería de Sanidad de la Comunidad de Madrid
Consejería de Sanidad de la Comunidad de Madrid

Exploratory studies using human fetal tissue have suggested that intrastriatal transplantation of dopaminergic neurons may become a future treatment for patients with Parkinson’s disease. However, the use of human fetal tissue is compromised by eth

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4ead19db9da940d8615e20dd49c9c770
http://hdl.handle.net/10261/179403