The APE2 nuclease is essential for DNA double-strand break repair by microhomology-mediated end joining

Autor: Fleury, Hubert, MacEachern, Myles K., Stiefel, Clara M., Anand, Roopesh, Sempeck, Colin, Nebenfuehr, Benjamin, Maurer-Alcalá, Kelper, Ball, Kerri, Proctor, Bruce, III, Belan, Ondrej, Taylor, Erin, Ortega, Raquel, Dodd, Benjamin, Weatherly, Laila, Dansoko, Djelika, Leung, Justin W., Boulton, Simon J., Arnoult, Nausica

Publikováno v: In Molecular Cell 4 May 2023 83(9):1429-1445

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Rare SNP in the HELB gene interferes with RPA interaction and cellular function of HELB.

Autor: Osei B; Department of Biochemistry and Molecular Biology, University of Arkansas for Medical Sciences, Little Rock, Arkansas, 72205, USA., May BH; Department of Biochemistry and Molecular Biology, University of Arkansas for Medical Sciences, Little Rock, Arkansas, 72205, USA., Stiefel CM; Department of Biochemistry and Molecular Biology, University of Arkansas for Medical Sciences, Little Rock, Arkansas, 72205, USA., West KL; Department of Biochemistry and Molecular Biology, University of Arkansas for Medical Sciences, Little Rock, Arkansas, 72205, USA.; Winthrop P. Rockefeller Cancer Institute, Little Rock, Arkansas, 72205, USA., Zafar MK; Department of Biochemistry and Molecular Biology, University of Arkansas for Medical Sciences, Little Rock, Arkansas, 72205, USA., Thompson MD; Department of Biochemistry and Molecular Biology, University of Arkansas for Medical Sciences, Little Rock, Arkansas, 72205, USA., Bergstrom E; Department of Biological Sciences, Missouri University of Science and Technology, Rolla, Missouri, 72205, USA., Leung JW; Department of Radiation Oncology, University of Texas Health Science Center San Antonio, San Antonio, Texas, 78229, USA., Enemark EJ; Department of Biochemistry and Molecular Biology, University of Arkansas for Medical Sciences, Little Rock, Arkansas, 72205, USA.; Winthrop P. Rockefeller Cancer Institute, Little Rock, Arkansas, 72205, USA., Byrd AK; Department of Biochemistry and Molecular Biology, University of Arkansas for Medical Sciences, Little Rock, Arkansas, 72205, USA.; Winthrop P. Rockefeller Cancer Institute, Little Rock, Arkansas, 72205, USA.

Publikováno v: BioRxiv : the preprint server for biology [bioRxiv] 2024 Mar 02. Date of Electronic Publication: 2024 Mar 02.