Enhanced immunogenicity of a functional enzyme by T cell epitope modification

Autor: Collier Kathy, Saldajeno Mae, Ganshaw Grant, Poulose AJ, Stickler Marcia M, Mucha Jeanette M, Huang Manley T, Harding Fiona A

Publikováno v: BMC Immunology, Vol 3, Iss 1, p 2 (2002)

Abstract Background T helper epitopes are necessary for the induction of high titers of antigen-specific IgG antibodies. We are interested in the epitope modification of intact proteins as a method to enhance their immunogenicity for the generation o

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Targeting the aminopeptidase ERAP enhances antitumor immunity by disrupting the NKG2A-HLA-E inhibitory checkpoint.

Autor: Tsao HW; Broad Institute of Massachusetts Institute of Technology and Harvard, Cambridge, MA, USA; Center for Cancer Research, Massachusetts General Hospital, Boston, MA, USA., Anderson S; Broad Institute of Massachusetts Institute of Technology and Harvard, Cambridge, MA, USA; Center for Cancer Research, Massachusetts General Hospital, Boston, MA, USA., Finn KJ; Calico Life Sciences, South San Francisco, CA, USA., Perera JJ; Broad Institute of Massachusetts Institute of Technology and Harvard, Cambridge, MA, USA; Center for Cancer Research, Massachusetts General Hospital, Boston, MA, USA., Pass LF; Broad Institute of Massachusetts Institute of Technology and Harvard, Cambridge, MA, USA; Center for Cancer Research, Massachusetts General Hospital, Boston, MA, USA., Schneider EM; Broad Institute of Massachusetts Institute of Technology and Harvard, Cambridge, MA, USA; Center for Cancer Research, Massachusetts General Hospital, Boston, MA, USA., Jiang A; Broad Institute of Massachusetts Institute of Technology and Harvard, Cambridge, MA, USA; Center for Cancer Research, Massachusetts General Hospital, Boston, MA, USA., Fetterman R; Broad Institute of Massachusetts Institute of Technology and Harvard, Cambridge, MA, USA; Center for Cancer Research, Massachusetts General Hospital, Boston, MA, USA., Chuong CL; Broad Institute of Massachusetts Institute of Technology and Harvard, Cambridge, MA, USA; Center for Cancer Research, Massachusetts General Hospital, Boston, MA, USA., Kozuma K; Broad Institute of Massachusetts Institute of Technology and Harvard, Cambridge, MA, USA; Center for Cancer Research, Massachusetts General Hospital, Boston, MA, USA., Stickler MM; Calico Life Sciences, South San Francisco, CA, USA., Creixell M; Calico Life Sciences, South San Francisco, CA, USA., Klaeger S; Broad Institute of Massachusetts Institute of Technology and Harvard, Cambridge, MA, USA., Phulphagar KM; Broad Institute of Massachusetts Institute of Technology and Harvard, Cambridge, MA, USA., Rachimi S; Broad Institute of Massachusetts Institute of Technology and Harvard, Cambridge, MA, USA., Verzani EK; Broad Institute of Massachusetts Institute of Technology and Harvard, Cambridge, MA, USA., Olsson N; Calico Life Sciences, South San Francisco, CA, USA., Dubrot J; Broad Institute of Massachusetts Institute of Technology and Harvard, Cambridge, MA, USA; Center for Cancer Research, Massachusetts General Hospital, Boston, MA, USA., Pech MF; Calico Life Sciences, South San Francisco, CA, USA., Silkworth W; Calico Life Sciences, South San Francisco, CA, USA., Lane-Reticker SK; Broad Institute of Massachusetts Institute of Technology and Harvard, Cambridge, MA, USA; Center for Cancer Research, Massachusetts General Hospital, Boston, MA, USA., Allen PM; Broad Institute of Massachusetts Institute of Technology and Harvard, Cambridge, MA, USA; Center for Cancer Research, Massachusetts General Hospital, Boston, MA, USA., Ibrahim K; Broad Institute of Massachusetts Institute of Technology and Harvard, Cambridge, MA, USA; Center for Cancer Research, Massachusetts General Hospital, Boston, MA, USA., Knudsen NH; Broad Institute of Massachusetts Institute of Technology and Harvard, Cambridge, MA, USA; Center for Cancer Research, Massachusetts General Hospital, Boston, MA, USA., Cheng AY; Broad Institute of Massachusetts Institute of Technology and Harvard, Cambridge, MA, USA; Center for Cancer Research, Massachusetts General Hospital, Boston, MA, USA., Long AH; Broad Institute of Massachusetts Institute of Technology and Harvard, Cambridge, MA, USA; Department of Pediatric Oncology, Dana-Farber Cancer Institute, Boston, MA, USA., Ebrahimi-Nik H; Broad Institute of Massachusetts Institute of Technology and Harvard, Cambridge, MA, USA; Center for Cancer Research, Massachusetts General Hospital, Boston, MA, USA., Kim SY; Broad Institute of Massachusetts Institute of Technology and Harvard, Cambridge, MA, USA; Center for Cancer Research, Massachusetts General Hospital, Boston, MA, USA., Du PP; Broad Institute of Massachusetts Institute of Technology and Harvard, Cambridge, MA, USA; Center for Cancer Research, Massachusetts General Hospital, Boston, MA, USA., Iracheta-Vellve A; Broad Institute of Massachusetts Institute of Technology and Harvard, Cambridge, MA, USA; Center for Cancer Research, Massachusetts General Hospital, Boston, MA, USA., Robitschek EJ; Broad Institute of Massachusetts Institute of Technology and Harvard, Cambridge, MA, USA; Center for Cancer Research, Massachusetts General Hospital, Boston, MA, USA., Suermondt JSMT; Broad Institute of Massachusetts Institute of Technology and Harvard, Cambridge, MA, USA; Center for Cancer Research, Massachusetts General Hospital, Boston, MA, USA., Davis TGR; Broad Institute of Massachusetts Institute of Technology and Harvard, Cambridge, MA, USA; Center for Cancer Research, Massachusetts General Hospital, Boston, MA, USA., Wolfe CH; Broad Institute of Massachusetts Institute of Technology and Harvard, Cambridge, MA, USA; Center for Cancer Research, Massachusetts General Hospital, Boston, MA, USA., Atluri T; Broad Institute of Massachusetts Institute of Technology and Harvard, Cambridge, MA, USA; Center for Cancer Research, Massachusetts General Hospital, Boston, MA, USA., Olander KE; Broad Institute of Massachusetts Institute of Technology and Harvard, Cambridge, MA, USA; Center for Cancer Research, Massachusetts General Hospital, Boston, MA, USA., Rush JS; Broad Institute of Massachusetts Institute of Technology and Harvard, Cambridge, MA, USA., Sundberg TB; Broad Institute of Massachusetts Institute of Technology and Harvard, Cambridge, MA, USA., McAllister FE; Calico Life Sciences, South San Francisco, CA, USA., Abelin JG; Broad Institute of Massachusetts Institute of Technology and Harvard, Cambridge, MA, USA., Firestone A; Calico Life Sciences, South San Francisco, CA, USA., Stokoe D; Calico Life Sciences, South San Francisco, CA, USA., Carr SA; Broad Institute of Massachusetts Institute of Technology and Harvard, Cambridge, MA, USA., Harding FA; Calico Life Sciences, South San Francisco, CA, USA. Electronic address: fah@calicolabs.com., Yates KB; Broad Institute of Massachusetts Institute of Technology and Harvard, Cambridge, MA, USA; Center for Cancer Research, Massachusetts General Hospital, Boston, MA, USA; Department of Medicine, Massachusetts General Hospital, Boston, MA, USA. Electronic address: yates@broadinstitute.org., Manguso RT; Broad Institute of Massachusetts Institute of Technology and Harvard, Cambridge, MA, USA; Center for Cancer Research, Massachusetts General Hospital, Boston, MA, USA; Department of Medicine, Massachusetts General Hospital, Boston, MA, USA. Electronic address: rmanguso@broadinstitute.org.

Publikováno v: Immunity [Immunity] 2024 Nov 13. Date of Electronic Publication: 2024 Nov 13.