Passively administered fluoxetine reaches the juvenile brain of FSL rats and reduces antioxidant defences, without altering serotonin turnover.

Autor: Steyn SF; Centre of Excellence for Pharmaceutical Sciences, Faculty of Health Sciences, North-West University, Hoffman Street, Potchefstroom, 2531, South Africa. Stephan.steyn@nwu.ac.za., Rheeders M; Centre of Excellence for Pharmaceutical Sciences, Faculty of Health Sciences, North-West University, Hoffman Street, Potchefstroom, 2531, South Africa., Viljoen FP; Centre of Excellence for Pharmaceutical Sciences, Faculty of Health Sciences, North-West University, Hoffman Street, Potchefstroom, 2531, South Africa., Brand L; Centre of Excellence for Pharmaceutical Sciences, Faculty of Health Sciences, North-West University, Hoffman Street, Potchefstroom, 2531, South Africa.

Publikováno v: BMC pharmacology & toxicology [BMC Pharmacol Toxicol] 2024 Aug 16; Vol. 25 (1), pp. 51. Date of Electronic Publication: 2024 Aug 16.

Use of a gene expression signature to identify trimetazidine for repurposing to treat bipolar depression.

Autor: Bortolasci CC; IMPACT, The Institute for Mental and Physical Health and Clinical Translation, School of Medicine, Deakin University, Geelong, Australia., Kidnapillai S; IMPACT, The Institute for Mental and Physical Health and Clinical Translation, School of Medicine, Deakin University, Geelong, Australia., Spolding B; IMPACT, The Institute for Mental and Physical Health and Clinical Translation, School of Medicine, Deakin University, Geelong, Australia., Truong TTT; IMPACT, The Institute for Mental and Physical Health and Clinical Translation, School of Medicine, Deakin University, Geelong, Australia., Connor T; IMPACT, The Institute for Mental and Physical Health and Clinical Translation, School of Medicine, Deakin University, Geelong, Australia., Swinton C; IMPACT, The Institute for Mental and Physical Health and Clinical Translation, School of Medicine, Deakin University, Geelong, Australia., Panizzutti B; IMPACT, The Institute for Mental and Physical Health and Clinical Translation, School of Medicine, Deakin University, Geelong, Australia., Liu ZSJ; IMPACT, The Institute for Mental and Physical Health and Clinical Translation, School of Medicine, Deakin University, Geelong, Australia., Sanigorski A; IMPACT, The Institute for Mental and Physical Health and Clinical Translation, School of Medicine, Deakin University, Geelong, Australia., Dean OM; IMPACT, The Institute for Mental and Physical Health and Clinical Translation, School of Medicine, Deakin University, Geelong, Australia.; The Florey Institute of Neuroscience and Mental Health, Parkville, Australia., Crowley T; IMPACT, The Institute for Mental and Physical Health and Clinical Translation, School of Medicine, Deakin University, Geelong, Australia.; Bioinformatics Core Research Facility (BCRF), Deakin University, Geelong, Australia., Richardson M; Bioinformatics Core Research Facility (BCRF), Deakin University, Geelong, Australia., Bozaoglu K; Murdoch Children's Research Institute, Parkville, Victoria, Australia.; Department of Paediatrics, University of Melbourne, Parkville, Victoria, Australia., Vlahos K; Murdoch Children's Research Institute, Parkville, Victoria, Australia., Cowdery S; IMPACT, The Institute for Mental and Physical Health and Clinical Translation, School of Medicine, Deakin University, Geelong, Australia., Watmuff B; IMPACT, The Institute for Mental and Physical Health and Clinical Translation, School of Medicine, Deakin University, Geelong, Australia., Steyn SF; Centre of Excellence for Pharmaceutical Sciences, Faculty of Health Sciences, North-West University, Potchefstroom, South Africa., Wolmarans W; Centre of Excellence for Pharmaceutical Sciences, Faculty of Health Sciences, North-West University, Potchefstroom, South Africa., Engelbrecht BJ; Centre of Excellence for Pharmaceutical Sciences, Faculty of Health Sciences, North-West University, Potchefstroom, South Africa., Perry C; The Florey Institute of Neuroscience and Mental Health, Parkville, Australia., Drummond K; The Florey Institute of Neuroscience and Mental Health, Parkville, Australia., Pang T; The Florey Institute of Neuroscience and Mental Health, Parkville, Australia., Jamain S; Univ Paris Est Créteil, INSERM, IMRB, Translational Neuropsychiatry, AP-HP, DMU IMPACT, FHU ADAPT, Fondation FondaMental, Créteil, France., Gray L; IMPACT, The Institute for Mental and Physical Health and Clinical Translation, School of Medicine, Deakin University, Geelong, Australia.; The Florey Institute of Neuroscience and Mental Health, Parkville, Australia., McGee SL; IMPACT, The Institute for Mental and Physical Health and Clinical Translation, School of Medicine, Deakin University, Geelong, Australia., Harvey BH; Centre of Excellence for Pharmaceutical Sciences, Faculty of Health Sciences, North-West University, Potchefstroom, South Africa.; SAMRC Unit on Risk and Resilience in Mental Disorders, Department of Psychiatry and Mental Health and Neuroscience Institute, University of Cape Town, Cape Town, South Africa., Kim JH; IMPACT, The Institute for Mental and Physical Health and Clinical Translation, School of Medicine, Deakin University, Geelong, Australia.; The Florey Institute of Neuroscience and Mental Health, Parkville, Australia., Leboyer M; Univ Paris Est Créteil, INSERM, IMRB, Translational Neuropsychiatry, AP-HP, DMU IMPACT, FHU ADAPT, Fondation FondaMental, Créteil, France., Berk M; IMPACT, The Institute for Mental and Physical Health and Clinical Translation, School of Medicine, Deakin University, Geelong, Australia.; The Florey Institute of Neuroscience and Mental Health, Parkville, Australia.; Orygen, The National Centre of Excellence in Youth Mental Health, Parkville, Australia., Walder K; IMPACT, The Institute for Mental and Physical Health and Clinical Translation, School of Medicine, Deakin University, Geelong, Australia.

Publikováno v: Bipolar disorders [Bipolar Disord] 2023 Dec; Vol. 25 (8), pp. 661-670. Date of Electronic Publication: 2023 Mar 23.

Genetically predisposed and resilient animal models of depression reveal divergent responses to early-life adversity.

Autor: Whitney AJ; Centre of Excellence for Pharmaceutical Sciences, Faculty of Health Sciences, North-West University, Potchefstroom, South Africa., Lindeque Z; Human Metabolomics, Faculty of Natural and Agricultural Sciences, North-West University, Potchefstroom, South Africa., Kruger R; Hypertension in African Research Team (HART), North-West University, Potchefstroom, South Africa.; MRC Research Unit for Hypertension and Cardiovascular Disease, North-West University, Potchefstroom, South Africa., Steyn SF; Centre of Excellence for Pharmaceutical Sciences, Faculty of Health Sciences, North-West University, Potchefstroom, South Africa.

Publikováno v: Acta neuropsychiatrica [Acta Neuropsychiatr] 2023 Aug 18, pp. 1-13. Date of Electronic Publication: 2023 Aug 18.

Reviewing the mitochondrial dysfunction paradigm in rodent models as platforms for neuropsychiatric disease research.

Autor: van Rensburg DJ; Centre of Excellence for Pharmaceutical Sciences, Faculty of Health Sciences, North-West University, Potchefstroom, South Africa., Lindeque Z; Human Metabolomics, Faculty of Natural and Agricultural Sciences, North-West University, Potchefstroom, South Africa., Harvey BH; Centre of Excellence for Pharmaceutical Sciences, Faculty of Health Sciences, North-West University, Potchefstroom, South Africa; South African Medical Research Council Unit on Risk and Resilience in Mental Disorders, Department of Psychiatry and Neuroscience Institute, University of Cape Town, South Africa., Steyn SF; Centre of Excellence for Pharmaceutical Sciences, Faculty of Health Sciences, North-West University, Potchefstroom, South Africa. Electronic address: Stephan.steyn@nwu.ac.za.

Publikováno v: Mitochondrion [Mitochondrion] 2022 May; Vol. 64, pp. 82-102. Date of Electronic Publication: 2022 Mar 17.

Stereotypy and spontaneous alternation in deer mice and its response to anti-adenosinergic intervention.

Autor: de Brouwer G; Center of Excellence for Pharmaceutical Sciences, Department of Pharmacology, Faculty of Health Sciences, North-West University, Potchefstroom, South Africa., Engelbrecht J; Center of Excellence for Pharmaceutical Sciences, Department of Pharmacology, Faculty of Health Sciences, North-West University, Potchefstroom, South Africa., Mograbi DC; Department of Psychology, Pontifícia Universidade Católica - Rio (PUC-Rio), Rio de Janeiro, Brazil.; Institute of Psychiatry, Psychology & Neuroscience, King's College London, London, UK., Legoabe L; Center of Excellence for Pharmaceutical Sciences, Department of Pharmacology, Faculty of Health Sciences, North-West University, Potchefstroom, South Africa., Steyn SF; Center of Excellence for Pharmaceutical Sciences, Department of Pharmacology, Faculty of Health Sciences, North-West University, Potchefstroom, South Africa., Wolmarans W; Center of Excellence for Pharmaceutical Sciences, Department of Pharmacology, Faculty of Health Sciences, North-West University, Potchefstroom, South Africa.

Publikováno v: Journal of neuroscience research [J Neurosci Res] 2021 Oct; Vol. 99 (10), pp. 2706-2720. Date of Electronic Publication: 2021 Jun 11.