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Akademický článek

Design and Synthesis of Clinical Candidate PF-06852231 (CVL-231): A Brain Penetrant, Selective, Positive Allosteric Modulator of the M 4 Muscarinic Acetylcholine Receptor.

Autor: Butler CR; Medicine Design, Medicinal Chemistry, Pfizer Inc., Cambridge, Massachusetts 02139, United States., Popiolek M; Internal Medicine, Pfizer Inc., Cambridge, Massachusetts 02139, United States., McAllister LA; Medicine Design, Medicinal Chemistry, Pfizer Inc., Cambridge, Massachusetts 02139, United States., LaChapelle EA; Medicine Design, Medicinal Chemistry, Pfizer Inc., Groton, Connecticut 06340, United States., Kramer M; Medicine Design, Pharmacokinetics, Dynamics and Metabolism, Pfizer Inc., Groton, Connecticut 06340, United States., Beck EM; Medicine Design, Medicinal Chemistry, Pfizer Inc., Cambridge, Massachusetts 02139, United States., Mente S; Medicine Design, Medicinal Chemistry, Pfizer Inc., Cambridge, Massachusetts 02139, United States., Brodney MA; Medicine Design, Medicinal Chemistry, Pfizer Inc., Cambridge, Massachusetts 02139, United States., Brown M; Medicine Design, Medicinal Chemistry, Pfizer Inc., Groton, Connecticut 06340, United States., Gilbert A; Medicine Design, Medicinal Chemistry, Pfizer Inc., Groton, Connecticut 06340, United States., Helal C; Medicine Design, Medicinal Chemistry, Pfizer Inc., Groton, Connecticut 06340, United States., Ogilvie K; Medicine Design, Medicinal Chemistry, Pfizer Inc., Groton, Connecticut 06340, United States., Starr J; Medicine Design, Medicinal Chemistry, Pfizer Inc., Groton, Connecticut 06340, United States., Uccello D; Medicine Design, Medicinal Chemistry, Pfizer Inc., Groton, Connecticut 06340, United States., Grimwood S; Internal Medicine, Pfizer Inc., Cambridge, Massachusetts 02139, United States., Edgerton J; Internal Medicine, Pfizer Inc., Cambridge, Massachusetts 02139, United States., Garst-Orozco J; Internal Medicine, Pfizer Inc., Cambridge, Massachusetts 02139, United States., Kozak R; Internal Medicine, Pfizer Inc., Cambridge, Massachusetts 02139, United States., Lotarski S; Internal Medicine, Pfizer Inc., Cambridge, Massachusetts 02139, United States., Rossi A; Internal Medicine, Pfizer Inc., Cambridge, Massachusetts 02139, United States., Smith D; Internal Medicine, Pfizer Inc., Cambridge, Massachusetts 02139, United States., O'Connor R; Discovery Sciences, Primary Pharmacology, Pfizer Inc., Groton, Connecticut 06340, United States., Lazzaro J; Discovery Sciences, Primary Pharmacology, Pfizer Inc., Groton, Connecticut 06340, United States., Steppan C; Discovery Sciences, Primary Pharmacology, Pfizer Inc., Groton, Connecticut 06340, United States., Steyn SJ; Medicine Design, Pharmacokinetics, Dynamics and Metabolism, Pfizer Inc., Groton, Connecticut 06340, United States.

Publikováno v: Journal of medicinal chemistry [J Med Chem] 2024 Jul 11; Vol. 67 (13), pp. 10831-10847. Date of Electronic Publication: 2024 Jun 18.

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Akademický článek

Discovery of Clinical Candidate PF-06648671: A Potent γ-Secretase Modulator for the Treatment of Alzheimer's Disease.

Autor: Pettersson M; Pfizer Worldwide Research and Development, Cambridge, Massachusetts 02139, United States., Johnson DS; Pfizer Worldwide Research and Development, Cambridge, Massachusetts 02139, United States., Humphrey JM; Pfizer Worldwide Research and Development, Groton, Connecticut 06340, United States., Am Ende CW; Pfizer Worldwide Research and Development, Groton, Connecticut 06340, United States., Butler TW; Pfizer Worldwide Research and Development, Groton, Connecticut 06340, United States., Dorff PH; Pfizer Worldwide Research and Development, Groton, Connecticut 06340, United States., Efremov IV; Pfizer Worldwide Research and Development, Groton, Connecticut 06340, United States., Evrard E; Pfizer Worldwide Research and Development, Cambridge, Massachusetts 02139, United States., Green ME; Pfizer Worldwide Research and Development, Cambridge, Massachusetts 02139, United States., Helal CJ; Pfizer Worldwide Research and Development, Groton, Connecticut 06340, United States., Kauffman GW; Pfizer Worldwide Research and Development, Cambridge, Massachusetts 02139, United States., Mullins PB; Pfizer Worldwide Research and Development, Groton, Connecticut 06340, United States., Navaratnam T; Pfizer Worldwide Research and Development, Groton, Connecticut 06340, United States., O'Donnell CJ; Pfizer Worldwide Research and Development, Groton, Connecticut 06340, United States., O'Sullivan TJ; Pfizer Worldwide Research and Development, Groton, Connecticut 06340, United States., Patel NC; Pfizer Worldwide Research and Development, Cambridge, Massachusetts 02139, United States., Stepan AF; Pfizer Worldwide Research and Development, Cambridge, Massachusetts 02139, United States., Stiff CM; Pfizer Worldwide Research and Development, Groton, Connecticut 06340, United States., Subramanyam C; Pfizer Worldwide Research and Development, Groton, Connecticut 06340, United States., Trapa P; Pfizer Worldwide Research and Development, Cambridge, Massachusetts 02139, United States., Tran TP; Pfizer Worldwide Research and Development, Groton, Connecticut 06340, United States., Vetelino BC; Pfizer Worldwide Research and Development, Groton, Connecticut 06340, United States., Yang E; Pfizer Worldwide Research and Development, Groton, Connecticut 06340, United States., Xie L; Pfizer Worldwide Research and Development, Groton, Connecticut 06340, United States., Pustilnik LR; Pfizer Worldwide Research and Development, Groton, Connecticut 06340, United States., Steyn SJ; Pfizer Worldwide Research and Development, Cambridge, Massachusetts 02139, United States., Wood KM; Pfizer Worldwide Research and Development, Groton, Connecticut 06340, United States., Bales KR; Pfizer Worldwide Research and Development, Cambridge, Massachusetts 02139, United States., Hajos-Korcsok E; Pfizer Worldwide Research and Development, Cambridge, Massachusetts 02139, United States., Verhoest PR; Pfizer Worldwide Research and Development, Cambridge, Massachusetts 02139, United States.

Publikováno v: Journal of medicinal chemistry [J Med Chem] 2024 Jun 27; Vol. 67 (12), pp. 10248-10262. Date of Electronic Publication: 2024 Jun 07.

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