Zobrazeno 1 - 10
of 12
pro vyhledávání: '"Steyn, JS"'
Autor:
Widdrington, JD, Gomez-Duran, A, Steyn, JS, Pyle, A, Ruchaud-Sparagano, M-H, Scott, J, Baudouin, SV, Rostron, AJ, Simpson, J, Chinnery FMedSci, PF
Monocytes from sepsis patients have mitochondrial DNA (mtDNA) depletion and immune deactivation. Here we find that THP-1 cell immune responses are impaired by experimentally depleting mtDNA, through dysregulated immune signalling, and rescued by inte
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::03274b52a3e6bafd1b4e916d8eae7f5b
Autor:
Volpe KE; Vanderbilt University Medical Center, Nashville, TN, USA., Samuels DC; Vanderbilt University School of Medicine, Nashville, TN, USA., Elson JL; Biosciences Institute, Newcastle University, Newcastle Upon Tyne, UK., Steyn JS; Biosciences Institute, Newcastle University, Newcastle Upon Tyne, UK., Gebretsadik T; Vanderbilt University Medical Center, Nashville, TN, USA., Ellis RJ; Univ. of California San Diego, San Diego, CA, USA., Heaton RK; Univ. of California San Diego, San Diego, CA, USA., Kallianpur AR; Cleveland Clinic/Lerner Research Institute, Cleveland, OH, USA., Letendre S; Univ. of California San Diego, San Diego, CA, USA., Hulgan T; Vanderbilt University Medical Center, Nashville, TN, USA. Electronic address: todd.hulgan@vumc.org.
Publikováno v:
Mitochondrion [Mitochondrion] 2024 Jan; Vol. 74, pp. 101820. Date of Electronic Publication: 2023 Nov 19.
Autor:
Wong J; The Bioscience Institute, Newcastle University, Newcastle upon Tyne, United Kingdom., Steyn JS; Research Software Engineering, Newcastle Helix, Newcastle upon Tyne, United Kingdom., Pienaar IS; Institute of Clinical Sciences, University of Birmingham, Edgbaston, United Kingdom., Elson JL; The Bioscience Institute, Newcastle University, Newcastle upon Tyne, United Kingdom.; The Centre for Human Metabolomics, North-West University, Potchefstroom, South Africa.
Publikováno v:
PloS one [PLoS One] 2022 Oct 20; Vol. 17 (10), pp. e0276169. Date of Electronic Publication: 2022 Oct 20 (Print Publication: 2022).
Autor:
Schliewert EC; Department of Companion Animal Clinical Studies, Faculty of Veterinary Medicine, University of Pretoria, Pretoria, South Africa., Hooijberg EH; Department of Companion Animal Clinical Studies, Faculty of Veterinary Medicine, University of Pretoria, Pretoria, South Africa., Steyn JS; Deltamune Ltd, Centurion, South Africa., Potgieter C; Human Metabolomics, Faculty of Natural and Agricultural Sciences, North-West University, Potchefstroom, South Africa., Fosgate GT; Department of Production Animal Studies, Faculty of Veterinary Medicine, University of Pretoria, Pretoria, South Africa., Goddard A; Department of Companion Animal Clinical Studies, Faculty of Veterinary Medicine, University of Pretoria, Pretoria, South Africa.
Publikováno v:
American journal of veterinary research [Am J Vet Res] 2022 Oct 13; Vol. 83 (11), pp. 1-11. Date of Electronic Publication: 2022 Oct 13.
Autor:
Mellough CB; Institute of Genetic Medicine, Newcastle University, Newcastle NE1 3BZ, UK.; Lions Eye Institute, 2 Verdun Street, Nedlands, Perth, WA 6009, Australia., Bauer R; School of Computing, Newcastle University, Newcastle NE4 5TG, UK., Collin J; Institute of Genetic Medicine, Newcastle University, Newcastle NE1 3BZ, UK., Dorgau B; Institute of Genetic Medicine, Newcastle University, Newcastle NE1 3BZ, UK., Zerti D; Institute of Genetic Medicine, Newcastle University, Newcastle NE1 3BZ, UK., Dolan DWP; Department of Biosciences, Durham University, Stockton Road, Durham DH1 3LE, UK., Jones CM; Department of Biosciences, Durham University, Stockton Road, Durham DH1 3LE, UK., Izuogu OG; Institute of Genetic Medicine, Newcastle University, Newcastle NE1 3BZ, UK.; European Bioinformatics Institute (EMBL-EBI), Wellcome Genome Campus, Cambridge CB10 1SD, UK., Yu M; Institute of Genetic Medicine, Newcastle University, Newcastle NE1 3BZ, UK., Hallam D; Institute of Genetic Medicine, Newcastle University, Newcastle NE1 3BZ, UK., Steyn JS; Institute of Genetic Medicine, Newcastle University, Newcastle NE1 3BZ, UK., White K; EM Research Services, Newcastle University, Newcastle NE2 4HH, UK., Steel DH; Institute of Genetic Medicine, Newcastle University, Newcastle NE1 3BZ, UK., Santibanez-Koref M; Institute of Genetic Medicine, Newcastle University, Newcastle NE1 3BZ, UK., Elliott DJ; Institute of Genetic Medicine, Newcastle University, Newcastle NE1 3BZ, UK., Jackson MS; Institute of Genetic Medicine, Newcastle University, Newcastle NE1 3BZ, UK., Lindsay S; Institute of Genetic Medicine, Newcastle University, Newcastle NE1 3BZ, UK., Grellscheid S; Department of Biosciences, Durham University, Stockton Road, Durham DH1 3LE, UK., Lako M; Institute of Genetic Medicine, Newcastle University, Newcastle NE1 3BZ, UK majlinda.lako@ncl.ac.uk.
Publikováno v:
Development (Cambridge, England) [Development] 2019 Jan 29; Vol. 146 (2). Date of Electronic Publication: 2019 Jan 29.
Autor:
Ehrmann I; Institute of Genetic Medicine, Newcastle University, Newcastle, United Kingdom., Crichton JH; MRC Human Genetics Unit, MRC Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh, United Kingdom., Gazzara MR; Department of Genetics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, United States.; Department of Biochemistry and Biophysics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, United States., James K; Life Sciences, Natural History Museum, London, United Kingdom., Liu Y; Institute of Genetic Medicine, Newcastle University, Newcastle, United Kingdom.; Department of Plant and Microbial Biology, University of Zürich, Zürich, Switzerland., Grellscheid SN; Institute of Genetic Medicine, Newcastle University, Newcastle, United Kingdom.; School of Biological and Biomedical Sciences, University of Durham, Durham, United Kingdom., Curk T; Laboratory of Bioinformatics, Faculty of Computer and Information Sciences, University of Ljubljana, Ljubljana, Slovenia., de Rooij D; Reproductive Biology Group, Division of Developmental Biology, Department of Biology, Faculty of Science, Utrecht University, Utrecht, The Netherlands.; Center for Reproductive Medicine, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands., Steyn JS; Bioinformatics Support Unit, Faculty of Medical Sciences, Newcastle University, Newcastle, United Kingdom., Cockell S; Bioinformatics Support Unit, Faculty of Medical Sciences, Newcastle University, Newcastle, United Kingdom., Adams IR; MRC Human Genetics Unit, MRC Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh, United Kingdom., Barash Y; Department of Genetics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, United States.; Department of Computer and Information Science, University of Pennsylvania, Philadelphia, United States., Elliott DJ; Institute of Genetic Medicine, Newcastle University, Newcastle, United Kingdom.
Publikováno v:
ELife [Elife] 2019 Jan 24; Vol. 8. Date of Electronic Publication: 2019 Jan 24.
Autor:
Queen RA; Institute of Genetic Medicine, Newcastle University, Newcastle-upon-Tyne, United Kingdom., Steyn JS; Institute of Genetic Medicine, Newcastle University, Newcastle-upon-Tyne, United Kingdom., Lord P; School of Computing Science, Newcastle University, Newcastle-upon-Tyne, United Kingdom., Elson JL; Institute of Genetic Medicine, Newcastle University, Newcastle-upon-Tyne, United Kingdom.; Centre for Human Metabonomics, North-West University, Potchefstroom, South Africa.
Publikováno v:
PloS one [PLoS One] 2017 Nov 21; Vol. 12 (11), pp. e0187862. Date of Electronic Publication: 2017 Nov 21 (Print Publication: 2017).
Autor:
Widdrington JD; Institute of Cellular Medicine, Newcastle University, Newcastle upon Tyne, United Kingdom; Institute of Genetic Medicine, Newcastle University, Newcastle upon Tyne, United Kingdom., Gomez-Duran A; Institute of Genetic Medicine, Newcastle University, Newcastle upon Tyne, United Kingdom; Medical Research Council Mitochondrial Biology Unit, Cambridge Biomedical Campus, Cambridge, United Kingdom., Steyn JS; Institute of Genetic Medicine, Newcastle University, Newcastle upon Tyne, United Kingdom; Bioinformatics Support Unit, Faculty of Medical Sciences, Newcastle University, Newcastle upon Tyne, United Kingdom., Pyle A; Institute of Genetic Medicine, Newcastle University, Newcastle upon Tyne, United Kingdom., Ruchaud-Sparagano MH; Institute of Cellular Medicine, Newcastle University, Newcastle upon Tyne, United Kingdom., Scott J; Institute of Cellular Medicine, Newcastle University, Newcastle upon Tyne, United Kingdom., Baudouin SV; Department of Anaesthesia, Royal Victoria Infirmary, Newcastle upon Tyne, United Kingdom., Rostron AJ; Institute of Cellular Medicine, Newcastle University, Newcastle upon Tyne, United Kingdom., Simpson J; Institute of Cellular Medicine, Newcastle University, Newcastle upon Tyne, United Kingdom. Electronic address: j.simpson@ncl.ac.uk., Chinnery PF; Institute of Genetic Medicine, Newcastle University, Newcastle upon Tyne, United Kingdom; Medical Research Council Mitochondrial Biology Unit, Cambridge Biomedical Campus, Cambridge, United Kingdom; Department of Clinical Neurosciences, University of Cambridge, Cambridge, United Kingdom. Electronic address: pfc25@cam.ac.uk.
Publikováno v:
The Journal of allergy and clinical immunology [J Allergy Clin Immunol] 2017 Nov; Vol. 140 (5), pp. 1461-1464.e8. Date of Electronic Publication: 2017 Jun 17.
Autor:
Steyn JS; Bioinformatics Support Unit, Newcastle University, Newcastle upon Tyne, NE1 7RU, UK. jannetta.steyn@newcastle.ac.uk., Andras P; School of Computing and Mathematics, Keele University, Keele, ST5 5BG, UK.
Publikováno v:
Journal of computational neuroscience [J Comput Neurosci] 2017 Apr; Vol. 42 (2), pp. 107-121. Date of Electronic Publication: 2016 Oct 24.
Autor:
Alhasan AA; Institute of Genetic Medicine, Newcastle University, Newcastle upon Tyne, United Kingdom;, Izuogu OG; Institute of Genetic Medicine, Newcastle University, Newcastle upon Tyne, United Kingdom;, Al-Balool HH; Kuwait Medical Genetics Centre, Al-Sabah Medical Area, Kuwait City, Kuwait;, Steyn JS; Institute of Genetic Medicine, Newcastle University, Newcastle upon Tyne, United Kingdom; Bioinformatics Support Unit, Faculty of Medical Sciences, Newcastle University, Newcastle upon Tyne, United Kingdom;, Evans A; National Health Service Blood and Transplant, Department of Haematology, University of Cambridge, Cambridge, United Kingdom;, Colzani M; National Health Service Blood and Transplant, Department of Haematology, University of Cambridge, Cambridge, United Kingdom;, Ghevaert C; National Health Service Blood and Transplant, Department of Haematology, University of Cambridge, Cambridge, United Kingdom;, Mountford JC; Institute of Cardiovascular and Medical Sciences, University of Glasgow, Glasgow, United Kingdom; and Tissue and Cellular Therapies, Research Development & Innovation, Scottish National Blood Transfusion Service, Glasgow, United Kingdom., Marenah L; Tissue and Cellular Therapies, Research Development & Innovation, Scottish National Blood Transfusion Service, Glasgow, United Kingdom., Elliott DJ; Institute of Genetic Medicine, Newcastle University, Newcastle upon Tyne, United Kingdom;, Santibanez-Koref M; Institute of Genetic Medicine, Newcastle University, Newcastle upon Tyne, United Kingdom;, Jackson MS; Institute of Genetic Medicine, Newcastle University, Newcastle upon Tyne, United Kingdom;
Publikováno v:
Blood [Blood] 2016 Mar 03; Vol. 127 (9), pp. e1-e11. Date of Electronic Publication: 2015 Dec 10.