Zobrazeno 1 - 10
of 75
pro vyhledávání: '"Stewart W, Morris"'
Autor:
Danni A. Gadd, Robert F. Hillary, Daniel L. McCartney, Liu Shi, Aleks Stolicyn, Neil A. Robertson, Rosie M. Walker, Robert I. McGeachan, Archie Campbell, Shen Xueyi, Miruna C. Barbu, Claire Green, Stewart W. Morris, Mathew A. Harris, Ellen V. Backhouse, Joanna M. Wardlaw, J. Douglas Steele, Diego A. Oyarzún, Graciela Muniz-Terrera, Craig Ritchie, Alejo Nevado-Holgado, Tamir Chandra, Caroline Hayward, Kathryn L. Evans, David J. Porteous, Simon R. Cox, Heather C. Whalley, Andrew M. McIntosh, Riccardo E. Marioni
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-14 (2022)
Characterising associations between the methylome, proteome and phenome may provide insight into biological pathways governing brain health. Here, blood protein markers of brain health are integrated with omics data to reveal DNA methylation differen
Externí odkaz:
https://doaj.org/article/1eaa7fc6efbf4260a056871f0b0cae03
Autor:
Xueyi Shen, Doretta Caramaschi, Mark J. Adams, Rosie M. Walker, Josine L. Min, Alex Kwong, Gibran Hemani, Genetics of DNA Methylation Consortium, Miruna C. Barbu, Heather C. Whalley, Sarah E. Harris, Ian J. Deary, Stewart W. Morris, Simon R. Cox, Caroline L. Relton, Riccardo E. Marioni, Kathryn L. Evans, Andrew M. McIntosh
Publikováno v:
Genome Medicine, Vol 14, Iss 1, Pp 1-16 (2022)
Abstract Background Depression is a disabling and highly prevalent condition where genetic and epigenetic, such as DNA methylation (DNAm), differences contribute to disease risk. DNA methylation is influenced by genetic variation but the association
Externí odkaz:
https://doaj.org/article/d2acf3cdcee6403f88223fb30ff43ea6
Autor:
Rebecca A. Madden, Daniel L. McCartney, Rosie M. Walker, Robert F. Hillary, Mairead L. Bermingham, Konrad Rawlik, Stewart W. Morris, Archie Campbell, David J. Porteous, Ian J. Deary, Kathryn L. Evans, Jonathan Hafferty, Andrew M. McIntosh, Riccardo E. Marioni
Publikováno v:
Epigenetics, Vol 16, Iss 7, Pp 783-796 (2021)
The Developmental Origins of Health and Disease (DOHaD) theory predicts that prenatal and early life events shape adult health outcomes. Birth weight is a useful indicator of the foetal experience and has been associated with multiple adult health ou
Externí odkaz:
https://doaj.org/article/13261fa4fb5349a6b5e69ca273903023
Autor:
Rosie M. Walker, Kadi Vaher, Mairead L. Bermingham, Stewart W. Morris, Andrew D. Bretherick, Yanni Zeng, Konrad Rawlik, Carmen Amador, Archie Campbell, Chris S. Haley, Caroline Hayward, David J. Porteous, Andrew M. McIntosh, Riccardo E. Marioni, Kathryn L. Evans
Publikováno v:
Genome Medicine, Vol 13, Iss 1, Pp 1-14 (2021)
Abstract Background The apolipoprotein E (APOE) ε4 allele is the strongest genetic risk factor for late onset Alzheimer’s disease, whilst the ε2 allele confers protection. Previous studies report differential DNA methylation of APOE between ε4 a
Externí odkaz:
https://doaj.org/article/bd0517e9a0c94aa1a3d1249941375734
Autor:
Miruna C. Barbu, Carmen Amador, Alex S.F. Kwong, Xueyi Shen, Mark J. Adams, David M. Howard, Rosie M. Walker, Stewart W. Morris, Josine L. Min, Chunyu Liu, Jenny van Dongen, Mohsen Ghanbari, Caroline Relton, David J. Porteous, Archie Campbell, Kathryn L. Evans, Heather C. Whalley, Andrew M. McIntosh
Publikováno v:
EBioMedicine, Vol 79, Iss , Pp 104000- (2022)
Summary: Background: DNA methylation (DNAm) is associated with time-varying environmental factors that contribute to major depressive disorder (MDD) risk. We sought to test whether DNAm signatures of lifestyle and biochemical factors were associated
Externí odkaz:
https://doaj.org/article/f2438b9b8f5a489eb3648ba1916d4d96
Autor:
Daniel Trejo Banos, Daniel L. McCartney, Marion Patxot, Lucas Anchieri, Thomas Battram, Colette Christiansen, Ricardo Costeira, Rosie M. Walker, Stewart W. Morris, Archie Campbell, Qian Zhang, David J. Porteous, Allan F. McRae, Naomi R. Wray, Peter M. Visscher, Chris S. Haley, Kathryn L. Evans, Ian J. Deary, Andrew M. McIntosh, Gibran Hemani, Jordana T. Bell, Riccardo E. Marioni, Matthew R. Robinson
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-14 (2020)
Linking epigenetic marks to clinical outcomes promises insight into the underlying processes. Here, the authors introduce a statistical approach to estimate associations between a phenotype and all epigenetic probes jointly, and to estimate the propo
Externí odkaz:
https://doaj.org/article/74bbcbe2232d46d983d1a26fad579404
Autor:
Daniel L. McCartney, Futao Zhang, Robert F. Hillary, Qian Zhang, Anna J. Stevenson, Rosie M. Walker, Mairead L. Bermingham, Thibaud Boutin, Stewart W. Morris, Archie Campbell, Alison D. Murray, Heather C. Whalley, David J. Porteous, Caroline Hayward, Kathryn L. Evans, Tamir Chandra, Ian J. Deary, Andrew M. McIntosh, Jian Yang, Peter M. Visscher, Allan F. McRae, Riccardo E. Marioni
Publikováno v:
Genome Medicine, Vol 12, Iss 1, Pp 1-11 (2019)
Abstract Background Advanced age is associated with cognitive and physical decline and is a major risk factor for a multitude of disorders. There is also a gap in life expectancy between males and females. DNA methylation differences have been shown
Externí odkaz:
https://doaj.org/article/8184cb0748bd44328eeb2be72f9dbcf1
Autor:
Yanni Zeng, Carmen Amador, Chenhao Gao, Rosie M. Walker, Stewart W. Morris, Archie Campbell, Azra Frkatović, Rebecca A Madden, Mark J. Adams, Shuai He, Andrew D. Bretherick, Caroline Hayward, David J. Porteous, James F. Wilson, Kathryn L. Evans, Andrew M. McIntosh, Pau Navarro, Chris S. Haley
Publikováno v:
EBioMedicine, Vol 74, Iss , Pp 103730- (2021)
Background: parent-of-origin effects (POE) play important roles in complex disease and thus understanding their regulation and associated molecular and phenotypic variation are warranted. Previous studies mainly focused on the detection of genomic re
Externí odkaz:
https://doaj.org/article/074223ccfeb54427999eb66fd69ca4a5
Autor:
Mairead L. Bermingham, Rosie M. Walker, Riccardo E. Marioni, Stewart W. Morris, Konrad Rawlik, Yanni Zeng, Archie Campbell, Paul Redmond, Heather C. Whalley, Mark J. Adams, Caroline Hayward, Ian J. Deary, David J. Porteous, Andrew M. McIntosh, Kathryn L. Evans
Publikováno v:
EBioMedicine, Vol 43, Iss , Pp 576-586 (2019)
Background: The causes of poor respiratory function and COPD are incompletely understood, but it is clear that genes and the environment play a role. As DNA methylation is under both genetic and environmental control, we hypothesised that investigati
Externí odkaz:
https://doaj.org/article/74237a89b93840df9a569393164b3074
Autor:
Yanni Zeng, Carmen Amador, Charley Xia, Riccardo Marioni, Duncan Sproul, Rosie M. Walker, Stewart W. Morris, Andrew Bretherick, Oriol Canela-Xandri, Thibaud S. Boutin, David W. Clark, Archie Campbell, Konrad Rawlik, Caroline Hayward, Reka Nagy, Albert Tenesa, David J. Porteous, James F. Wilson, Ian J. Deary, Kathryn L. Evans, Andrew M. McIntosh, Pau Navarro, Chris S. Haley
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-13 (2019)
Parent-of-origin effects (POE) are observed when there are different effects from alleles inherited from the two parents on phenotypic measures. Here, Zeng et al. study POE on DNA methylation in 5,101 individuals and identify genetic variants that as
Externí odkaz:
https://doaj.org/article/13fb59ef0899422fa835edb1cbd7b338