Zobrazeno 1 - 10
of 110
pro vyhledávání: '"Stewart N. Loh"'
Autor:
Mohammad Ahmad, Jeung-Hoi Ha, Lauren A. Mayse, Maria F. Presti, Aaron J. Wolfe, Kelsey J. Moody, Stewart N. Loh, Liviu Movileanu
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-14 (2023)
Sensitive and accurate approaches for protein detection have many potential applications. Here the authors show how engineered protein nanopore sensors, consisting of a monobody fused to a single-polypeptide nanopore, can be used for highly specific
Externí odkaz:
https://doaj.org/article/1f2b1191daee43b2bc50ec7144ff89b9
Enhancing response of a protein conformational switch by using two disordered ligand binding domains
Publikováno v:
Frontiers in Molecular Biosciences, Vol 10 (2023)
Introduction: Protein conformational switches are often constructed by fusing an input domain, which recognizes a target ligand, to an output domain that establishes a biological response. Prior designs have employed binding-induced folding of the in
Externí odkaz:
https://doaj.org/article/35e72e9ba6864d34b5f29038a32f3c6c
Publikováno v:
Frontiers in Molecular Biosciences, Vol 9 (2022)
A large percentage of transcription factors require zinc to bind DNA. In this review, we discuss what makes p53 unique among zinc-dependent transcription factors. The conformation of p53 is unusually malleable: p53 binds zinc extremely tightly when f
Externí odkaz:
https://doaj.org/article/1fbf4fa9b2c742928e4cf2866141f47d
Autor:
Jing Zhao, Alan Blayney, Xiaorong Liu, Lauren Gandy, Weihua Jin, Lufeng Yan, Jeung-Hoi Ha, Ashley J. Canning, Michael Connelly, Chao Yang, Xinyue Liu, Yuanyuan Xiao, Michael S. Cosgrove, Sozanne R. Solmaz, Yingkai Zhang, David Ban, Jianhan Chen, Stewart N. Loh, Chunyu Wang
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-11 (2021)
Epigallocatechin gallate (EGCG) is a catechin flavonoid which induces apoptosis in cancerous cells, but the underlying molecular mechanisms remain poorly understood. Here authors use an interdisciplinary approach to show a direct interaction between
Externí odkaz:
https://doaj.org/article/bfe12496e2674532a1bf41a125983054
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-9 (2018)
The rational optimization of response times of protein conformational switches is a major challenge for biomolecular switch design. Here the authors present a generally applicable computational design strategy that in combination with biophysical exp
Externí odkaz:
https://doaj.org/article/94220e635e4c46a6835d838c064d7ecc
Autor:
Mark R. Woodford, Diana M. Dunn, Adam R. Blanden, Dante Capriotti, David Loiselle, Chrisostomos Prodromou, Barry Panaretou, Philip F. Hughes, Aaron Smith, Wendi Ackerman, Timothy A. Haystead, Stewart N. Loh, Dimitra Bourboulia, Laura S. Schmidt, W. Marston Linehan, Gennady Bratslavsky, Mehdi Mollapour
Publikováno v:
Nature Communications, Vol 7, Iss 1, Pp 1-15 (2016)
Hsp90 is required for the folding, stability and activity of several drivers of oncogenesis. Here the authors show that Folliculin-interacting proteins (FNIP) 1 and 2, whose expression correlates with the cellular response to Hsp90 inhibitors, are co
Externí odkaz:
https://doaj.org/article/51f03ab61e4442f99c334fc8fe1d2ccd
Autor:
Stewart N. Loh
Publikováno v:
Biomolecules, Vol 10, Iss 2, p 303 (2020)
The mutational landscape of p53 in cancer is unusual among tumor suppressors because most of the alterations are of the missense type and localize to a single domain: the ~220 amino acid DNA-binding domain. Nearly all of these mutations produce the c
Externí odkaz:
https://doaj.org/article/c92919129dcd4a19b28f72cde7698ee0
Autor:
Darren R. Carpizo, S. David Kimball, Stewart N. Loh, David A. Boothman, John Gilleran, Alan J. Blayney, Bing Na, Tracy Withers, Yue Liu, Adam R. Blanden, Anthony F. Bencivenga, Xin Yu, Saif Zaman
Supplementary tables to show combination index values for combination treatments of indicated compounds. Supplementary Table 1. Combination Index values for initial combination treatment of ZMC1 with chemotherapy drugs; Supplementary Table 2. Combina
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7b552ac3dcc2e7479c6659a9b74c1df4
https://doi.org/10.1158/1535-7163.22505851.v1
https://doi.org/10.1158/1535-7163.22505851.v1
Autor:
Darren R. Carpizo, S. David Kimball, Stewart N. Loh, David A. Boothman, John Gilleran, Alan J. Blayney, Bing Na, Tracy Withers, Yue Liu, Adam R. Blanden, Anthony F. Bencivenga, Xin Yu, Saif Zaman
Suppl. Fig. S1 display ZMC1 structure. Suppl. Fig. S2 showed no synergy in combination treatment of ZMC1 and Adriamycin or IR. Suppl. Fig. S3 showed synergy in Detroit 562 cells by combination treatment of ZMC1 and Irinotecan in the presence of GSH.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::373924276ceb44d0f28384c120bb1228
https://doi.org/10.1158/1535-7163.22505854
https://doi.org/10.1158/1535-7163.22505854
Autor:
Darren R. Carpizo, S. David Kimball, Stewart N. Loh, David A. Boothman, John Gilleran, Alan J. Blayney, Bing Na, Tracy Withers, Yue Liu, Adam R. Blanden, Anthony F. Bencivenga, Xin Yu, Saif Zaman
Suppl. Methods included the methods used in the paper, Cell growth inhibition assay, Immunofluorescent staining, Synthesis of ZMC1, Synthesis of 2,2'-((2-Ethoxy-2-oxoethyl)azanediyl)diacetic acid (NTA-MEE) and NTA-DEE, Zn2+-Kd measurements by competi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7118ac2756632efdd25988ccd02b669d
https://doi.org/10.1158/1535-7163.22505848.v1
https://doi.org/10.1158/1535-7163.22505848.v1