Zobrazeno 1 - 10
of 34
pro vyhledávání: '"Stewart Leung"'
Autor:
Hongying Yang, Wei Zhang, Heng Pan, Heidi G Feldser, Elden Lainez, Christine Miller, Stewart Leung, Zhong Zhong, Huizhen Zhao, Sharon Sweitzer, Thomas Considine, Thomas Riera, Vipin Suri, Brian White, James L Ellis, George P Vlasuk, Christine Loh
Publikováno v:
PLoS ONE, Vol 7, Iss 9, p e46364 (2012)
Chronic inflammation is a major contributing factor in the pathogenesis of many age-associated diseases. One central protein that regulates inflammation is NF-κB, the activity of which is modulated by post-translational modifications as well as by a
Externí odkaz:
https://doaj.org/article/a56d628fd5a94f1da31e23a4f38bf9f6
Autor:
Sisi Wang, Lijun Peng, Ziyan Zhu, Jian-Qing Mi, Yushan Kong, Stewart Leung, Yuebo Zhou, Jin Wang, Xiaoqiang Yan, Wenqian Xu
Publikováno v:
Frontiers of medicine. 16(1)
The CD19-targeting bispecific T-cell engager blinatumomab has shown remarkable efficacy in patients with relapsed/refractory B-cell precursor acute lymphoblastic leukemia. However, several studies showed that blinatumomab has a short plasma half-life
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e6d5467cb60150a270f04d79e7121d10
https://pubmed.ncbi.nlm.nih.gov/34463907
https://pubmed.ncbi.nlm.nih.gov/34463907
Autor:
Xiaoxia Song, Feng Ren, Qian Liu, Yafei Huang, Wei Cai, Zhijun Xiang, Jia-Ning Xiang, Tang Ting, Qianqian Wu, Yingli Ma, Xichen Lin, Mercedes Lobera, Guifeng Zhang, Ling Zhou, Liming Shao, Ting Yang, Stewart Leung, Liuqing Yang, Wang Yonghui, Lisa A. Orband-Miller
Publikováno v:
ACS Medicinal Chemistry Letters. 9:120-124
Biaryl amides as new RORγt modulators were discovered. The crystal structure of biaryl amide agonist 6 in complex with RORγt ligand binding domain (LBD) was resolved, and both “short” and “long” inverse agonists were obtained by removing fr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::55a87da15f60b2a1ed850fe7080392df
https://doi.org/10.1021/acsmedchemlett.7b00476
https://doi.org/10.1021/acsmedchemlett.7b00476
Autor:
Wei Zhang, Sijie Lu, Ling Zhou, Jia-Ning Xiang, Qian Liu, Yingli Ma, John D. Elliott, Stewart Leung, Yi Li, Liuqing Yang, Feng Ren, Kathleen Zhang, Wang Yonghui, Lisa A. Orband-Miller, Xichen Lin, Zhijun Xiang, Ziqiang Cheng, Qianqian Wu, Ting Yang
Publikováno v:
Bioorganic & Medicinal Chemistry. 23:5293-5302
A novel series of N-(4-aryl-5-aryloxy-thiazol-2-yl)-amides as RORγt inverse agonists was discovered. Binding mode analysis of a RORγt partial agonist (2c) revealed by co-crystal structure in RORγt LBD suggests that the inverse agonists do not dire
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::72530aff4a2e5a8933192d8ae588ae65
https://doi.org/10.1016/j.bmc.2015.07.068
https://doi.org/10.1016/j.bmc.2015.07.068
Autor:
Xichen Lin, John D. Elliott, Zhijun Xiang, Han Fangbin, Sijie Lu, Yaobang Cheng, Yan Xu, Stewart Leung, Feng Ren, Yong-Gang Zhao, Wei Cai, Ling Zhou, Qian Liu, Qinghua Meng, Jia-Ning Xiang, Guifeng Zhang, Wang Yonghui, Ziqiang Cheng, Ting Yang, Yafei Huang, Qianqian Wu
Publikováno v:
ACS Medicinal Chemistry Letters. 6:787-792
A novel series of biaryl amides was identified as RORγt inhibitors through core replacement of a starting hit 1. Structure-activity relationship exploration on the biaryl moiety led to discovery of potent RORγt inhibitors with good oral bioavailabi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a75f4b025d5582c9797c1cbebfdef3ca
https://doi.org/10.1021/acsmedchemlett.5b00122
https://doi.org/10.1021/acsmedchemlett.5b00122
Autor:
Ling Zhou, Sijie Lu, Qianqian Wu, Yong-Gang Zhao, Zhong Zhong, Xichen Lin, Ruina Gao, Melanie Huxdorf, Shuai Wang, Wei Zhang, John D. Elliott, Ziqiang Cheng, Qian Liu, Yingli Ma, Yonghui Wang, Yaobang Cheng, Zhijun Xiang, Ting Yang, Yan Xu, Jia-Ning Xiang, Stewart Leung, Wei Cai, Lisa A. Orband-Miller, Liuqing Yang, Guifeng Zhang, Jing Zhang
Publikováno v:
Bioorganic & Medicinal Chemistry. 22:692-702
Novel series of N-(5-(arylcarbonyl)thiazol-2-yl)amides and N-(5-(arylcarbonyl)thiophen-2-yl)amides were discovered as potent retinoic acid receptor-related orphan receptor-gamma-t (RORγt) inhibitors. SAR studies of the RORγt HTS hit 6a led to ident
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::266961618b709678a1572f5a6ad4de9c
https://doi.org/10.1016/j.bmc.2013.12.021
https://doi.org/10.1016/j.bmc.2013.12.021
Autor:
Liuqing Yang, Zhijun Xiang, Zhong Zhong, Melanie Huxdorf, Stewart Leung, Xichen Lin, Ling Zhou, Yang Qiu, Ting Yang, Qianqian Wu, John D. Elliott, Wei Zhang, Jia-Ning Xiang, Wei Cai, Qian Liu, Yingli Ma, Yonghui Wang, Yaobang Cheng, Lisa A. Orband-Miller, Jing Zhang
Publikováno v:
ACS Medicinal Chemistry Letters. 5:65-68
A novel series of tertiary amines as retinoid-related orphan receptor gamma-t (RORγt) inverse agonists was discovered through agonist/inverse agonist conversion. The level of RORγt inhibition can be enhanced by modulating the conformational disrupt
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::72017bdcc523021747bf25673415fde4
https://doi.org/10.1021/ml4003875
https://doi.org/10.1021/ml4003875
Autor:
Wei Cao, Zhengyi Wang, Yiqing Yang, Ailian Liu, Chen Dong, Yufang Shi, Jingwu Z Zhang, Fenglan Wu, Stewart Leung, Jian Hong, Lei Fang
Publikováno v:
Immunity. 35:273-284
SummaryNeural progenitor cell (NPC) therapy is considered a promising treatment modality for multiple sclerosis (MS), potentially acting through neural repair. Here, we showed that intravenous administration of NPCs ameliorated experimental autoimmun
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2f5a53a6cc48963a5287b8c0639ee0c1
https://doi.org/10.1016/j.immuni.2011.06.011
https://doi.org/10.1016/j.immuni.2011.06.011
Publikováno v:
Cellular & Molecular Immunology. 7:182-189
The propagation and regulation of an immune response is driven by a network of effector and regulatory T (Treg) cells. The interplay of effector T and Treg cells determines the direction of the immune response towards inflammation or its resolution i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::06071506db78b169c34117bb47286c0a
https://doi.org/10.1038/cmi.2010.22
https://doi.org/10.1038/cmi.2010.22
Autor:
Hongtao Lu, Runsheng Li, Limin Lu, Taylor B Guo, Bing Wan, Jian Hong, Mingjuan Song, Ji Wang, Lei Fang, Xuebin Liu, Chunxia Wang, Stewart Leung, Jingwu Z Zhang, Ailian Liu, Yonggang Zhao, Xia Qin, Zhu Tan, Heng Pan
Publikováno v:
Nature Medicine. 16:191-197
Interleukin-7 receptor (IL-7R) is genetically associated with susceptibility to multiple sclerosis. Here we describe that IL-7 is essential for survival and expansion of pathogenic T helper type 17 (T(H)17) cells in experimental autoimmune encephalom
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0ab48341f19a62b59060aed4b117f0b5
https://doi.org/10.1038/nm.2077
https://doi.org/10.1038/nm.2077