Zobrazeno 1 - 10
of 12
pro vyhledávání: '"Stewart J. Wood"'
Autor:
Diptesh Sil, Hemamali J. Warshakoon, Thuan B. Nguyen, Sunil A. David, Stewart J. Wood, E. V. K. Suresh Kumar, Apurba Datta, Kelly A. Miller
Publikováno v:
Molecular Pharmaceutics. 5:1131-1137
Hydrophobically substituted polyamine compounds, particularly N-acyl or N-alkyl derivatives of homospermine, are potent endotoxin (lipopolysaccharide) sequestrants. Despite their polycationic nature, the aqueous solubilites are limited owing to the c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5f6ebce9244a2cde4fc91f63623b467a
https://doi.org/10.1021/mp8001123
https://doi.org/10.1021/mp8001123
Publikováno v:
Combinatorial Chemistry & High Throughput Screening. 7:733-743
Lipopolysaccharides (LPS), otherwise termed 'endotoxins', are an integral part of the outer leaflet of the outer-membrane of Gram-negative bacteria. Lipopolysaccharides play a pivotal role in the pathogenesis of 'Septic Shock', a major cause of morta
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dc319b05c31aefba2bd0b26a32e9e9dc
https://doi.org/10.2174/1386207043328229
https://doi.org/10.2174/1386207043328229
Autor:
Paul Williams, Alan Cockayne, Stewart J. Wood, Caroline Reynolds, Christine E. R. Dodd, Barrie W. Bycroft, Matthew T. G. Holden, Weng C. Chan, Zina Mariam Affas, Sandra Saint, Philip MDowell, Philip J. Hill
Publikováno v:
Molecular Microbiology. 41:503-512
In Staphylococcus aureus, the agr locus is responsible for controlling virulence gene expression via quorum sensing. As the blockade of quorum sensing offers a novel strategy for attenuating infection, we sought to gain novel insights into the struct
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7381fd5b54a092585a4e7cee9506ac10
https://doi.org/10.1046/j.1365-2958.2001.02539.x
https://doi.org/10.1046/j.1365-2958.2001.02539.x
Autor:
Rajalakshmi Balakrishna, Stewart J. Wood, Kelly A. Miller, Apurba Datta, E. V. K. Suresh Kumar, Sunil A. David, Thuan B. Nguyen
Publikováno v:
Antimicrobial agents and chemotherapy. 50(3)
A homologous series of mono- and bis-acyl polyamines with varying acyl chain lengths originally synthesized for the purpose of sequestering lipopolysaccharide were evaluated for antimicrobial activity to test the hypothesis that these bis-cationic am
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6014a70f361e32794d99c2a36789bc6b
https://pubmed.ncbi.nlm.nih.gov/16495242
https://pubmed.ncbi.nlm.nih.gov/16495242
Publikováno v:
Combinatorial chemistryhigh throughput screening. 9(1)
Lipopolysaccharides (LPS), otherwise termed 'endotoxins', are an integral part of the outer leaflet of the outer-membrane of Gram-negative bacteria. Lipopolysaccharides play a pivotal role in the pathogenesis of 'Septic Shock', a major cause of morta
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4c1d137aaac5e3fbef33b4eb9f819d78
https://pubmed.ncbi.nlm.nih.gov/16454684
https://pubmed.ncbi.nlm.nih.gov/16454684
Publikováno v:
Journal of combinatorial chemistry. 8(1)
Lipopolysaccharides (LPS), also called "endotoxins", are outer-membrane constituents of Gram-negative bacteria. Lipopolysaccharides play a key role in the pathogenesis of "septic shock", a major cause of mortality in the critically ill patient. We ha
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::51b6dffc0bf9f5ee77ae63160c3137a2
https://pubmed.ncbi.nlm.nih.gov/16398551
https://pubmed.ncbi.nlm.nih.gov/16398551
Autor:
Stewart J. Wood, Sunil A. David, Kriangsak Khownium, Thuan B. Nguyen, Matthew R. Kimbrell, Rajalakshmi Balakrishna, Kelly A. Miller, Gunda I. Georg
Publikováno v:
Bioorganicmedicinal chemistry letters. 16(5)
We have shown that lipopolyamines bind to the lipid A moiety of lipopolysaccharide, a constituent of Gram-negative bacterial membranes, and neutralize its toxicity in animal models of endotoxic shock. In an effort to identify non-polyamine scaffolds
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4cccb17cb9bfa246325281809e6c9689
https://pubmed.ncbi.nlm.nih.gov/16377188
https://pubmed.ncbi.nlm.nih.gov/16377188
Publikováno v:
Bioorganicmedicinal chemistry letters. 16(3)
Lipopolysaccharides (LPS), otherwise termed "endotoxins", are outer-membrane constituents of Gram-negative bacteria and play a key role in the pathogenesis of "septic shock", a major cause of mortality in the critically ill patient. We have shown tha
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::836c9c983901496cee53cfeadafa9426
https://pubmed.ncbi.nlm.nih.gov/16266804
https://pubmed.ncbi.nlm.nih.gov/16266804
Autor:
Kelly A. Miller, E. V. K. Suresh Kumar, Jens R. Cromer, Sunil A. David, and Apurba Datta, Stewart J. Wood
Publikováno v:
Journal of medicinal chemistry. 48(7)
Lipopolysaccharides (LPS), otherwise termed ‘endotoxins’, are outer-membrane constituents of Gram-negative bacteria. Lipopolysaccharides play a key role in the pathogenesis of ‘Septic Shock’, a major cause of mortality in the critically ill p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d4f7326424357981f09cb04e043e11f5
https://pubmed.ncbi.nlm.nih.gov/15801849
https://pubmed.ncbi.nlm.nih.gov/15801849
Publikováno v:
Bioorganicmedicinal chemistry letters. 15(5)
Lipopolysaccharides (LPS), otherwise termed 'endotoxins', are outer-membrane constituents of Gram-negative bacteria, and play a key role in the pathogenesis of 'Septic Shock', a major cause of mortality in the critically ill patient. We had previousl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f818f3cda378f6beb53afb3419dba18c
https://pubmed.ncbi.nlm.nih.gov/15713373
https://pubmed.ncbi.nlm.nih.gov/15713373