Zobrazeno 1 - 10
of 11
pro vyhledávání: '"Stewart Frescas"'
Autor:
Adam Pigott, Stewart Frescas, John D. McCorvy, Xi-Ping Huang, Bryan L. Roth, David E. Nichols
Publikováno v:
Beilstein Journal of Organic Chemistry, Vol 8, Iss 1, Pp 1705-1709 (2012)
A strategy to replace the ethylamine side chain of 2,5-dimethoxy-4-iodoamphetamine (DOI, 1a), and 2,5-dimethoxy-4-bromoamphetamine (DOB, 1b) with a cyclopropylamine moiety was successful in leading to compounds with high affinity at the 5-HT2 family
Externí odkaz:
https://doaj.org/article/e4a4e65219af4ebc8b2d67f16ff7a98c
Autor:
Xi Ping Huang, Adam Pigott, John D. McCorvy, Bryan L. Roth, David E. Nichols, Stewart Frescas
Publikováno v:
Beilstein Journal of Organic Chemistry, Vol 8, Iss 1, Pp 1705-1709 (2012)
Beilstein Journal of Organic Chemistry
Beilstein Journal of Organic Chemistry
A strategy to replace the ethylamine side chain of 2,5-dimethoxy-4-iodoamphetamine (DOI, 1a), and 2,5-dimethoxy-4-bromoamphetamine (DOB, 1b) with a cyclopropylamine moiety was successful in leading to compounds with high affinity at the 5-HT2 family
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::eabfb8666176be5aafefbe5ef586a588
https://doaj.org/article/e4a4e65219af4ebc8b2d67f16ff7a98c
https://doaj.org/article/e4a4e65219af4ebc8b2d67f16ff7a98c
Publikováno v:
Synthetic Communications. 34:2767-2771
The isolation of diastereomerically pure cis‐2,4‐pentanediol from a crude mixture of both cis‐ and trans‐2,4‐pentanediols is described through a short procedure involving thermodynamic acetal formation with acetophenone, followed by hydroge
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::282ea3ef23e91221c7e64db95fa45804
https://doi.org/10.1081/scc-200026213
https://doi.org/10.1081/scc-200026213
Publikováno v:
Journal of Medicinal Chemistry. 45:4344-4349
Lysergic acid amides were prepared from (R,R)-(-)-, (S,S)-(+)-, and cis-2,4-dimethyl azetidine. The dimethylazetidine moiety is considered here to be a rigid analogue of diethylamine, and thus, the target compounds are all conformationally constraine
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::51adceb7b30de983df83522944de607f
https://doi.org/10.1021/jm020153s
https://doi.org/10.1021/jm020153s
Publikováno v:
Synthetic Communications. 25:2775-2780
8-Methoxy-2-tetralone (6) can be easily prepared in approximately 50% overall yield starting from 2-bromophenylacetic acid (1), utilizing a Friedel-Crafts acylation/cyclization, ketone protection, copper(I)-catalyzed methoxylation of the aromatic bro
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::982ccc431bb6435e41c495d0cb92445b
https://doi.org/10.1080/00397919508011824
https://doi.org/10.1080/00397919508011824
Autor:
B. L. Roth, Gary A. Gudelsky, J. F. Nash, Xuemei Huang, David E. Nichols, Danuta Marona-Lewicka, Stewart Frescas
Publikováno v:
Journal of Medicinal Chemistry. 37:4346-4351
A method was found to synthesize 1-(2,5-dimethoxy-4-(trifluoromethyl) phenyl)-2-aminopropane, 5, and its des-alpha-methyl congener 2-(2,5-dimethoxy-4-(trifluoromethyl)phenyl)aminoethane, 6, the trifluoromethyl analogs of substituted hallucinogenic ph
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::634d570ef5caf6a8b03b0451836223bb
https://doi.org/10.1021/jm00051a011
https://doi.org/10.1021/jm00051a011
Publikováno v:
ChemInform. 22
The racemate and the enantiomers of 1-(3-methoxy-4-methyphenyl)-2- aminopropane (6) and racemic 5-methoxy-6-methyl-2-aminoindan (11) were tested for stimulus generalization in the two-lever drug-discrimination paradigm. Both 6 and 11 were found to su
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e605b2a06d0a1acf6e59bae33355b646
https://doi.org/10.1002/chin.199145138
https://doi.org/10.1002/chin.199145138
Publikováno v:
ChemInform. 26
8-Methoxy-2-tetralone (6) can be easily prepared in approximately 50% overall yield starting from 2-bromophenylacetic acid (1), utilizing a Friedel-Crafts acylation/cyclization, ketone protection, copper(I)-catalyzed methoxylation of the aromatic bro
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1f568bc519317985f569c67d59461b60
https://doi.org/10.1002/chin.199546114
https://doi.org/10.1002/chin.199546114
Publikováno v:
ChemInform. 35
The isolation of diastereomerically pure cis‐2,4‐pentanediol from a crude mixture of both cis‐ and trans‐2,4‐pentanediols is described through a short procedure involving thermodynamic acetal formation with acetophenone, followed by hydroge
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::824dcf3fb08426bae93616c71f87012f
https://doi.org/10.1002/chin.200452053
https://doi.org/10.1002/chin.200452053
Publikováno v:
Pharmacology, biochemistry, and behavior. 59(3)
N-Ethyl-5-trifluoromethyl-2-aminoindan (ETAI) and 5-trifluoromethyl-2-aminoindan (TAI) were synthesized to examine the effects of side-chain cyclization on the pharmacology of the anorectic drugs fenfluramine (FEN) and norfenfluramine (norFEN), respe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9d84b1bbc22f62dfca0552cf49556223
https://pubmed.ncbi.nlm.nih.gov/9512076
https://pubmed.ncbi.nlm.nih.gov/9512076