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of 18
pro vyhledávání: '"Stewart Frankel"'
Autor:
Dushyant Mishra, Kavitha Kannan, Kali Meadows, Jacob Macro, Michael Li, Stewart Frankel, Blanka Rogina
Publikováno v:
Frontiers in Aging, Vol 2 (2021)
I’m Not Dead Yet (Indy) is a fly homologue of the mammalian SLC13A5 (mSLC13A5) plasma membrane citrate transporter, a key metabolic regulator and energy sensor involved in health, longevity, and disease. Reduction of Indy gene activity in flies, an
Externí odkaz:
https://doaj.org/article/0adcf0a62f8047f5a740530a9152213d
Autor:
Stewart Frankel, Blanka Rogina
Publikováno v:
Frontiers in Genetics, Vol 12 (2021)
Aging has provided fruitful challenges for evolutionary theory, and evolutionary theory has deepened our understanding of aging. A great deal of genetic and molecular data now exists concerning mortality regulation and there is a growing body of know
Externí odkaz:
https://doaj.org/article/894a55401858427a9147b6709593330e
RPD3 histone deacetylase and nutrition have distinct but interacting effects on Drosophila longevity
Publikováno v:
Aging (Albany NY)
Single-gene mutations that extend longevity have revealed regulatory pathways related to aging and longevity. RPD3 is a conserved histone deacetylase (Class I HDAC). Previously we showed that Drosophila rpd3 mutations increase longevity. Here we test
Publikováno v:
Experimental Gerontology. 46:391-396
The silent information regulator 2 (Sir2 or Sirtuin) family of proteins is highly conserved and has been implicated in the extension of longevity for several species. Mammalian Sirtuins have been shown to affect various aspects of physiology includin
Publikováno v:
Radiation Research. 169:707-711
Drosophila melanogaster (fruit fly) is a well-established model organism for genetic studies of development and aging. We examined the effects of lethal ionizing radiation on male and female adult Drosophila of different ages, using doses of radiatio
Autor:
Stewart Frankel, Blanka Rogina
Publikováno v:
Aging Cell. 4:53-56
Two highly conserved histone deacetylases, Sir2 and Rpd3, have been linked to caloric restriction and the extension of longevity. Because the Drosophila forms of each protein can silence genes in either euchromatin or heterochromatin, we determined w
Autor:
Stewart Frankel, Blanka Rogina
Publikováno v:
Pathologie Biologie. 54:55-57
Autor:
Blanka Rogina, Stewart Frankel
Publikováno v:
Frontiers in Genetics
Frontiers in Genetics, Vol 3 (2012)
Frontiers in Genetics, Vol 3 (2012)
Indy encodes the fly homolog of a mammalian transporter of di and tricarboxylate components of the Krebs cycle. Reduced expression of fly Indy or two of the C. elegans Indy homologs leads to an increase in life span. Fly and worm tissues that play ke
Publikováno v:
Proceedings of the National Academy of Sciences. 88:1192-1196
Actin, like many other proteins, is highly insoluble after expression in Escherichia coli. In order to understand the origin of insoluble aggregates, we asked whether morphological inclusions were always correlated with insolubility. The strain expre
Publikováno v:
Journal of Biological Chemistry. 265:17980-17987
Wild type Dictyostelium discoideum actin (42 kDa) and a truncated form of actin were expressed in Escherichia coli. Amino-terminal sequencing indicated that the truncated species was composed of two peptides, which were the result of internal transla