Zobrazeno 1 - 10
of 115
pro vyhledávání: '"Stewart F Graham"'
Autor:
Ray O Bahado-Singh, Sangeetha Vishweswaraiah, Buket Aydas, Ali Yilmaz, Raghu P Metpally, David J Carey, Richard C Crist, Wade H Berrettini, George D Wilson, Khalid Imam, Michael Maddens, Halil Bisgin, Stewart F Graham, Uppala Radhakrishna
Publikováno v:
PLoS ONE, Vol 16, Iss 3, p e0248375 (2021)
We evaluated the utility of leucocyte epigenomic-biomarkers for Alzheimer's Disease (AD) detection and elucidates its molecular pathogeneses. Genome-wide DNA methylation analysis was performed using the Infinium MethylationEPIC BeadChip array in 24 l
Externí odkaz:
https://doaj.org/article/d9537ca420cb4d748465ee176c2f4948
Autor:
Ray Oliver Bahado-Singh, Ali Yilmaz, Halil Bisgin, Onur Turkoglu, Praveen Kumar, Eric Sherman, Andrew Mrazik, Anthony Odibo, Stewart F Graham
Publikováno v:
PLoS ONE, Vol 14, Iss 4, p e0214121 (2019)
ObjectiveTo interrogate the pathogenesis of intrauterine growth restriction (IUGR) and apply Artificial Intelligence (AI) techniques to multi-platform i.e. nuclear magnetic resonance (NMR) spectroscopy and mass spectrometry (MS) based metabolomic ana
Externí odkaz:
https://doaj.org/article/1fb464540d974cc095ec43e3907770b7
Autor:
Anusha Jayaraman, Praveen Kumar, Silvia Marin, Pedro de Atauri, Francesca Mateo, Timothy M Thomson, Josep J Centelles, Stewart F Graham, Marta Cascante
Publikováno v:
PLoS ONE, Vol 13, Iss 2, p e0192175 (2018)
Tumour angiogenesis is an important hallmark of cancer and the study of its metabolic adaptations, downstream to any cellular change, can reveal attractive targets for inhibiting cancer growth. In the tumour microenvironment, endothelial cells (ECs)
Externí odkaz:
https://doaj.org/article/7eab7ad70bd9435c9746990c0efeb787
Autor:
Stewart F Graham, Olivier P Chevallier, Christopher T Elliott, Christian Hölscher, Janet Johnston, Bernadette McGuinness, Patrick G Kehoe, Anthony Peter Passmore, Brian D Green
Publikováno v:
PLoS ONE, Vol 10, Iss 3, p e0119452 (2015)
This study combined high resolution mass spectrometry (HRMS), advanced chemometrics and pathway enrichment analysis to analyse the blood metabolome of patients attending the memory clinic: cases of mild cognitive impairment (MCI; n = 16), cases of MC
Externí odkaz:
https://doaj.org/article/cba83a6296df442594bd6e87713aa93f
Autor:
Ali Yilmaz, Sigal Liraz-Zaltsman, Esther Shohami, Juozas Gordevičius, Ieva Kerševičiūtė, Eric Sherman, Ray O. Bahado-Singh, Stewart F. Graham
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-14 (2023)
Abstract Traumatic brain injury (TBI) is a major cause of mortality and disability worldwide, particularly among individuals under the age of 45. It is a complex, and heterogeneous disease with a multifaceted pathophysiology that remains to be elucid
Externí odkaz:
https://doaj.org/article/52d7fe0c878a4d2bb6bc9d5e85acf5e4
Autor:
Xiaojian Shao, Sangeetha Vishweswaraiah, Miroslava Čuperlović-Culf, Ali Yilmaz, Celia M. T. Greenwood, Anuradha Surendra, Bernadette McGuinness, Peter Passmore, Patrick G. Kehoe, Michael E. Maddens, Steffany A. L. Bennett, Brian D. Green, Uppala Radhakrishna, Stewart F. Graham
Publikováno v:
Communications Biology, Vol 5, Iss 1, Pp 1-11 (2022)
Post-mortem brain tissue from patients with Dementia with Lewy bodies shows differentially methylated CpG sites and potential epigenetic associations with other conditions such as mood disorders and Parkinson’s Disease.
Externí odkaz:
https://doaj.org/article/3da129927f35494b86e1e49d82421630
Publikováno v:
Metabolites, Vol 13, Iss 12, p 1203 (2023)
Huntington’s disease (HD) is a progressive, fatal neurodegenerative disease characterized by motor, cognitive, and psychiatric symptoms. The precise mechanisms of HD progression are poorly understood; however, it is known that there is an expansion
Externí odkaz:
https://doaj.org/article/f906747b0cfb4e80856fd438ba215507
Autor:
Sangeetha Vishweswaraiah, Ali Yilmaz, Nazia Saiyed, Abdullah Khalid, Purvesh R. Koladiya, Xiaobei Pan, Shirin Macias, Andrew C. Robinson, David Mann, Brian D. Green, Ieva Kerševičiūte, Juozas Gordevičius, Uppala Radhakrishna, Stewart F. Graham
Publikováno v:
Genes, Vol 14, Iss 9, p 1752 (2023)
The impact of environmental factors on epigenetic changes is well established, and cellular function is determined not only by the genome but also by interacting partners such as metabolites. Given the significant impact of metabolism on disease prog
Externí odkaz:
https://doaj.org/article/93fd03e9411642f6963da55c26c2cbaf
Autor:
Wendy M. Miller, Kathryn M. Ziegler, Ali Yilmaz, Nazia Saiyed, Ilyas Ustun, Sumeyya Akyol, Jay Idler, Matthew D. Sims, Michael E. Maddens, Stewart F. Graham
Publikováno v:
Metabolites, Vol 13, Iss 4, p 506 (2023)
This prospective observational study aimed to evaluate the association of metabolomic alterations with weight loss outcomes following sleeve gastrectomy (SG). We evaluated the metabolomic profile of serum and feces prior to SG and three months post-S
Externí odkaz:
https://doaj.org/article/e16dd4639ba44b99b9ad9d121e3241f4
Autor:
Ray O. Bahado-Singh, Sangeetha Vishweswaraiah, Onur Turkoglu, Stewart F. Graham, Uppala Radhakrishna
Publikováno v:
International Journal of Molecular Sciences, Vol 24, Iss 3, p 2876 (2023)
Precision neurology combines high-throughput technologies and statistical modeling to identify novel disease pathways and predictive biomarkers in Alzheimer’s disease (AD). Brain cytochrome P450 (CYP) genes are major regulators of cholesterol, sex
Externí odkaz:
https://doaj.org/article/570e4154e45c4946b3af860ebff1f981