Zobrazeno 1 - 10
of 184
pro vyhledávání: '"Stewart F Graham"'
Autor:
Ali Yilmaz, Sigal Liraz-Zaltsman, Esther Shohami, Juozas Gordevičius, Ieva Kerševičiūtė, Eric Sherman, Ray O. Bahado-Singh, Stewart F. Graham
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-14 (2023)
Abstract Traumatic brain injury (TBI) is a major cause of mortality and disability worldwide, particularly among individuals under the age of 45. It is a complex, and heterogeneous disease with a multifaceted pathophysiology that remains to be elucid
Externí odkaz:
https://doaj.org/article/52d7fe0c878a4d2bb6bc9d5e85acf5e4
Autor:
Xiaojian Shao, Sangeetha Vishweswaraiah, Miroslava Čuperlović-Culf, Ali Yilmaz, Celia M. T. Greenwood, Anuradha Surendra, Bernadette McGuinness, Peter Passmore, Patrick G. Kehoe, Michael E. Maddens, Steffany A. L. Bennett, Brian D. Green, Uppala Radhakrishna, Stewart F. Graham
Publikováno v:
Communications Biology, Vol 5, Iss 1, Pp 1-11 (2022)
Post-mortem brain tissue from patients with Dementia with Lewy bodies shows differentially methylated CpG sites and potential epigenetic associations with other conditions such as mood disorders and Parkinson’s Disease.
Externí odkaz:
https://doaj.org/article/3da129927f35494b86e1e49d82421630
Publikováno v:
Metabolites, Vol 13, Iss 12, p 1203 (2023)
Huntington’s disease (HD) is a progressive, fatal neurodegenerative disease characterized by motor, cognitive, and psychiatric symptoms. The precise mechanisms of HD progression are poorly understood; however, it is known that there is an expansion
Externí odkaz:
https://doaj.org/article/f906747b0cfb4e80856fd438ba215507
Autor:
Sangeetha Vishweswaraiah, Ali Yilmaz, Nazia Saiyed, Abdullah Khalid, Purvesh R. Koladiya, Xiaobei Pan, Shirin Macias, Andrew C. Robinson, David Mann, Brian D. Green, Ieva Kerševičiūte, Juozas Gordevičius, Uppala Radhakrishna, Stewart F. Graham
Publikováno v:
Genes, Vol 14, Iss 9, p 1752 (2023)
The impact of environmental factors on epigenetic changes is well established, and cellular function is determined not only by the genome but also by interacting partners such as metabolites. Given the significant impact of metabolism on disease prog
Externí odkaz:
https://doaj.org/article/93fd03e9411642f6963da55c26c2cbaf
Autor:
Wendy M. Miller, Kathryn M. Ziegler, Ali Yilmaz, Nazia Saiyed, Ilyas Ustun, Sumeyya Akyol, Jay Idler, Matthew D. Sims, Michael E. Maddens, Stewart F. Graham
Publikováno v:
Metabolites, Vol 13, Iss 4, p 506 (2023)
This prospective observational study aimed to evaluate the association of metabolomic alterations with weight loss outcomes following sleeve gastrectomy (SG). We evaluated the metabolomic profile of serum and feces prior to SG and three months post-S
Externí odkaz:
https://doaj.org/article/e16dd4639ba44b99b9ad9d121e3241f4
Autor:
Ray O. Bahado-Singh, Sangeetha Vishweswaraiah, Onur Turkoglu, Stewart F. Graham, Uppala Radhakrishna
Publikováno v:
International Journal of Molecular Sciences, Vol 24, Iss 3, p 2876 (2023)
Precision neurology combines high-throughput technologies and statistical modeling to identify novel disease pathways and predictive biomarkers in Alzheimer’s disease (AD). Brain cytochrome P450 (CYP) genes are major regulators of cholesterol, sex
Externí odkaz:
https://doaj.org/article/570e4154e45c4946b3af860ebff1f981
Autor:
Sangeetha Vishweswaraiah, Sumeyya Akyol, Ali Yilmaz, Zafer Ugur, Juozas Gordevičius, Kyung Joon Oh, Patrik Brundin, Uppala Radhakrishna, Viviane Labrie, Stewart F. Graham
Publikováno v:
Frontiers in Neuroscience, Vol 16 (2022)
Parkinson’s disease (PD) is second most prevalent neurodegenerative disorder following Alzheimer’s disease. Parkinson’s disease is hypothesized to be caused by a multifaceted interplay between genetic and environmental factors. Herein, and for
Externí odkaz:
https://doaj.org/article/4e5cb75fdff04f49bba0fcfc9dbc0b47
Autor:
Ray O. Bahado-Singh, Uppala Radhakrishna, Juozas Gordevičius, Buket Aydas, Ali Yilmaz, Faryal Jafar, Khaled Imam, Michael Maddens, Kshetra Challapalli, Raghu P. Metpally, Wade H. Berrettini, Richard C. Crist, Stewart F. Graham, Sangeetha Vishweswaraiah
Publikováno v:
Cells, Vol 11, Iss 11, p 1744 (2022)
Background: Despite extensive efforts, significant gaps remain in our understanding of Alzheimer’s disease (AD) pathophysiology. Novel approaches using circulating cell-free DNA (cfDNA) have the potential to revolutionize our understanding of neuro
Externí odkaz:
https://doaj.org/article/26aa0b56552f485dae0c87a376ca3611
Autor:
Ray O Bahado-Singh, Sangeetha Vishweswaraiah, Buket Aydas, Ali Yilmaz, Raghu P Metpally, David J Carey, Richard C Crist, Wade H Berrettini, George D Wilson, Khalid Imam, Michael Maddens, Halil Bisgin, Stewart F Graham, Uppala Radhakrishna
Publikováno v:
PLoS ONE, Vol 16, Iss 3, p e0248375 (2021)
We evaluated the utility of leucocyte epigenomic-biomarkers for Alzheimer's Disease (AD) detection and elucidates its molecular pathogeneses. Genome-wide DNA methylation analysis was performed using the Infinium MethylationEPIC BeadChip array in 24 l
Externí odkaz:
https://doaj.org/article/d9537ca420cb4d748465ee176c2f4948
Autor:
Sumeyya Akyol, Zafer Ugur, Ali Yilmaz, Ilyas Ustun, Santosh Kapil Kumar Gorti, Kyungjoon Oh, Bernadette McGuinness, Peter Passmore, Patrick G. Kehoe, Michael E. Maddens, Brian D. Green, Stewart F. Graham
Publikováno v:
Cells, Vol 10, Iss 10, p 2591 (2021)
Alzheimer’s disease (AD) is reported to be closely linked with abnormal lipid metabolism. To gain a more comprehensive understanding of what causes AD and its subsequent development, we profiled the lipidome of postmortem (PM) human brains (neocort
Externí odkaz:
https://doaj.org/article/7e97e7aa856a4300b1114c825dd147b9