Výsledky vyhledávání - "Stewart C. Pearson"

Identification of a Series of Tricyclic Natural Products as Potent Broad-Spectrum Inhibitors of Metallo-β-Lactamases

Autor: David G. Tew, Alfonso Rivera-Sagredo, Paloma Perez, Cheryl A. Janson, Nestor O. Concha, Martin Gilpin, Juan A. Hueso-Rodríguez, Michael Rees, John H. Bateson, Jesús Ángel de la Fuente, Helen F. Boyd, Niconovich Nancy, Stewart C. Pearson, Christy Cheever, David J. Payne, E. Diez, Stephen Rittenhouse

Publikováno v: Antimicrobial Agents and Chemotherapy. 46:1880-1886

Metallo-β-lactamases provide bacteria with an efficient and effective way of mediating resistance to β-lactam-based antibacterial agents. More significantly, they confer resistance to carbapenems. Therefore, if metallo-β-lactamases increase in pre

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e9aa937c16cee0ca888b0a557de1cdef
https://doi.org/10.1128/aac.46.6.1880-1886.2002

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The bacA gene, which determines bacitracin susceptibility in Streptococcus pneumoniae and Staphylococcus aureus, is also required for virulence The GenBank accession number for the sequence reported in this paper is AF228662

Autor: David J. Holmes, Nicola G. Wallis, Alexander P. Bryant, Karen A. Ingraham, John Broskey, Stewart C. Pearson, Alison F. Chalker, Joanna Bryant, R. Dwayne Lunsford

Publikováno v: Microbiology. 146:1547-1553

Homologues of Escherichia coli bacA, encoding extremely hydrophobic proteins, were identified in the genomes of Staphylococcus aureus and Streptococcus pneumoniae. Allelic replacement mutagenesis demonstrated that the gene is not essential for in vit

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::9e0c8d587950bdffb6d3b1b9625212ca
https://doi.org/10.1099/00221287-146-7-1547

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Indole naphthyridinones as inhibitors of bacterial enoyl-ACP reductases FabI and FabK

Publikováno v: Journal of medicinal chemistry. 46(9)

Bacterial enoyl-ACP reductase (FabI) is responsible for catalyzing the final step of bacterial fatty acid biosynthesis and is an attractive target for the development of novel antibacterial agents. Previously we reported the development of FabI inhib

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a7ee8292abc59749735aeddbd0d1ed93
https://pubmed.ncbi.nlm.nih.gov/12699381

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Discovery of aminopyridine-based inhibitors of bacterial enoyl-ACP reductase (FabI)

Autor: William H, Miller, Mark A, Seefeld, Kenneth A, Newlander, Irene N, Uzinskas, Walter J, Burgess, Dirk A, Heerding, Catherine C K, Yuan, Martha S, Head, David J, Payne, Stephen F, Rittenhouse, Terrance D, Moore, Stewart C, Pearson, Valerie, Berry, Walter E, DeWolf, Paul M, Keller, Brian J, Polizzi, Xiayang, Qiu, Cheryl A, Janson, William F, Huffman

Publikováno v: Journal of medicinal chemistry. 45(15)

Bacterial enoyl-ACP reductase (FabI) catalyzes the final step in each cycle of bacterial fatty acid biosynthesis and is an attractive target for the development of new antibacterial agents. Our efforts to identify potent, selective FabI inhibitors be

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::88457e027bb10a51dc01df9d68bcf47b
https://pubmed.ncbi.nlm.nih.gov/12109908

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The bacA gene, which determines bacitracin susceptibility in Streptococcus pneumoniae and Staphylococcus aureus, is also required for virulence

Autor: Alison F, Chalker, Karen A, Ingraham, R Dwayne, Lunsford, Alexander P, Bryant, Joanna, Bryant, Nicola G, Wallis, John P, Broskey, Stewart C, Pearson, David J, Holmes

Publikováno v: Microbiology (Reading, England). 146

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::6c8f161e56df74522f9f7af6cf856ebb
https://pubmed.ncbi.nlm.nih.gov/10878119

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Inhibition of metallo-beta-lactamases by a series of thiol ester derivatives of mercaptophenylacetic acid

Autor: Stewart C. Pearson, David Proctor, Robert Reid, Teresa Khushi, Bateson John Hargreaves, David J. Payne, Brian Charles Gasson

Publikováno v: FEMS microbiology letters. 157(1)

A series of mercaptophenylacetic acid thiol esters bearing a phenyl substituent adjacent to the carboxylic acid function has been shown to be inhibitors of metallo-beta-lactamases. The inhibition of the Bacteroides fragilis CfiA and Bacillus cereus I

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::eb09cfa321807f92e482bc7c8bf9bbe6
https://pubmed.ncbi.nlm.nih.gov/9418252

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Clofoctol-Induced Ultrastructural Changes In Staphylococcus Aureus

Autor: Stewart C. Pearson, Timothy K. Hart, David J. Payne, Beverly E. Maleeff

Publikováno v: Microscopy and Microanalysis. 5:1138-1139

Clofoctol [2-(2,4-dichlorobenzyl)-4-(tetramethyl-l,l,3,3-butyl) phenol] is a synthetic antibacterial compound with activity against both Gram-positive1 and Gram-negative2 microorganisms. Although the specific mechanism of Clofoctol action has not bee

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::aa9a6a4175a18356751d8b3fdd992fa1
https://doi.org/10.1017/s1431927600019012

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