Zobrazeno 1 - 8
of 8
pro vyhledávání: '"Stewart J. Baker"'
Autor:
Laurent Salphati, Stewart J. Baker, Steve Price, Jim Nonomiya, Matthew C. Lucas, Timothy Hancox, David Knowles, Bohdan Waszkowycz, Neil Anthony Pegg, David Chantry, Bryan K. Chan, Paul Blaney, Anthony Brown, Steven T. Staben, Jodie Pang, Paul Depledge, Rama K. Kondru, Mark Ultsch, Paul Goldsmith, Karin Reif, Angelina Bisconte, Cristina Lewis, Eileen Mary Seward, Jeremy Murray, Brian Safina, Daniel P. Sutherlin, Zachary Kevin Sweeney, Georgette Castanedo, David Michael Goldstein, Jasmit Kaur, Sukhjit Sohal, Binqing Wei, John Lesnick, Stephen J. Shuttleworth, Alan Nadin
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 22:4296-4302
A potent inhibitor of PI3Kδ that is ⩾200 fold selective for the remaining three Class I PI3K isoforms and additional kinases is described. The hypothesis for selectivity is illustrated through structure activity relationships and crystal structure
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::92be9aea35b7ac14f79d9d789ee6948b
https://doi.org/10.1016/j.bmcl.2012.05.027
https://doi.org/10.1016/j.bmcl.2012.05.027
Autor:
Suzanne A. Eccles, Pauline Moore, Lori Friedman, Paul A. Clarke, Stewart J. Baker, Olivero Alan G, Gary Box, Anthony Robson, Paul Workman, Khatereh Ahmadi, Laurent Salphati, Nahid Saghir, Giles Pergl-Wilson, Irina Chuckowree, Mark H. Ultsch, Wendy K. Alderton, Marketa Zvelebil, Florence I. Raynaud, Sukhjit Sohal, Arumugam Kugendradas, Christian Wiesmann, Adrian Folkes, Sonal Patel, Letitia Lensun, Angela Hayes, Timothy Hancox, Stephen J. Shuttleworth, Alexander Zhyvoloup, Heidi J.A. Wallweber, Paul Depledge, Melanie Valenti, Sonia Alix, Nan Chi Wan, Jodie Pang
Publikováno v:
Journal of Medicinal Chemistry. 51:5522-5532
Phosphatidylinositol-3-kinase (PI3K) is an important target in cancer due to the deregulation of the PI3K/ Akt signaling pathway in a wide variety of tumors. A series of thieno[3,2-d]pyrimidine derivatives were prepared and evaluated as inhibitors of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9de0e3ae091925e99a0f90135c014d5f
https://doi.org/10.1021/jm800295d
https://doi.org/10.1021/jm800295d
Autor:
Hayley Farmer, Peter Charlton, Simon Cocks, Paul Depledge, Richard Faint, Irina Chuckowree, Deanne Thompson, Shouming Wang, Nan Chi Wan, Adrian Folkes, John W. Scott, Jan Broadbridge, Stewart J. Baker, John R. Harrison, Anthony Boyce, Sukhjit Sohal, Timothy Hancox, Warren Miller, Francis Xavier Wilson, Prakash Mistry, Caroline Freathy
Publikováno v:
Journal of Medicinal Chemistry. 47:1339-1350
In our continued effort to identify selective MRP1 modulators, we have developed two novel templates, 3 and 4, through rational drug design by identifying the key pharmacophore interaction at the 7-position of the pyrrolopyrimidine template 1. Furthe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7e0bee0b02b3618e536f0b7b91a6b068
https://doi.org/10.1021/jm0310129
https://doi.org/10.1021/jm0310129
Publikováno v:
Tetrahedron Letters. 37:1297-1300
The Ritter reactions of 3-alkyl-3-hydroxyazetidine or -piperidine derivatives give low yields of the desired products, whereas the 3-alkyl-3-hydroxy-pyrrolidine and 4-alkyl-4-hydroxy-piperidine derivatives react smoothly to give the corresponding ace
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9251e9094494fd58667906a572e2f972
https://doi.org/10.1016/0040-4039(95)02378-x
https://doi.org/10.1016/0040-4039(95)02378-x
Autor:
Steve Price, Georgette Castanedo, Fernando Padilla, Bohdan Waszkowycz, Christine Chabot, Neil Anthony Pegg, Laurent Salphati, Alan Nadin, Jun Li, Karin Reif, Raj K. Handa, Arnaud J. Cheguillaume, Timothy Hancox, Suzanne Tay, Pascal Savy, Parcharee Tivitmahaisoon, Zachary Kevin Sweeney, Jeremy Murray, Binqing Wei, Krintel Sussie Lerche, Qin Yue, Eileen Mary Seward, Sophie Mukadam, Rama K. Kondru, Pravin Iyer, Sukhjit Sohal, Jasmit Kaur, John Lesnick, Yung-Hsiang Chen, Daniel P. Sutherlin, Stephen J. Shuttleworth, Matthew W. Cartwright, Bindu Goyal, Paul M. Blaney, Paul Goldsmith, Jodie Pang, Matthew C. Lucas, Stewart J. Baker, Jim Nonomiya, Cristina Lewis, Wylie Solang Palmer, Chenghong Zhang, Brian Safina, Matt Baumgardner, Bryan K. Chan, David Michael Goldstein, Jane R. Kenny
Publikováno v:
Journal of medicinal chemistry. 55(12)
PI3Kδ is a lipid kinase and a member of a larger family of enzymes, PI3K class IA(α, β, δ) and IB (γ), which catalyze the phosphorylation of PIP2 to PIP3. PI3Kδ is mainly expressed in leukocytes, where it plays a critical, nonredundant role in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c8f3151193dd85c9e07e1ac655378624
https://pubmed.ncbi.nlm.nih.gov/22626259
https://pubmed.ncbi.nlm.nih.gov/22626259
Autor:
I. Najera, Sophie Le Pogam, Graham Maile, Hobbs Christopher John, JH Merrett, Steven Swallow, Carl Laxton, Julie Hang, Rene Devos, Stewart J. Baker, Han Ma, Keshab Sarma, Julian Symons, Klaus Klumpp, David Bernard Smith, Vincent Leveque, David R. Vesey, Peter Blomgren, Mark D. Smith, Arkadius Pichota, Joseph Armstrong Martin, W.R. Jiang, Caroline Granycome, Nick Cammack
Publikováno v:
Bioorganicmedicinal chemistry letters. 17(9)
A series of 4'-substituted ribonucleoside derivatives has been prepared and evaluated for inhibition of hepatitis C virus (HCV) RNA replication in cell culture. The most potent and non-cytotoxic derivative was compound 28 (4'-azidocytidine, R1479) wi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::75a5e8af068b7cffce86f83a0bd1b0c8
https://pubmed.ncbi.nlm.nih.gov/17317178
https://pubmed.ncbi.nlm.nih.gov/17317178
Autor:
Kevin E. B. Parkes, David J. Bushnell, Philippe Wong Kai-In, Andrew C. Freeman, Julie E Cansfield, JH Merrett, Ian R Johns, Stephen J. Dunsdon, Stewart J. Baker, Joseph Armstrong Martin, Mark Holland, Heather Simmonite, Andrea Walmsley, Robert Wilson Lambert, Gareth John Thomas, Elizabeth Keech, Richard A. Hopkins
Publikováno v:
Bioorganicmedicinal chemistry letters. 11(13)
A series of carboxamide derivatives of 5′-amino-2′,5′-dideoxy-5-ethyluridine has been prepared as inhibitors of HSV-TK (herpes simplex virus thymidine kinase). The most potent compounds were derived from xanthene, thioxanthene and dihydroanthra
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e55d79c544bf1e8d1e9a72ae0699f3ca
https://pubmed.ncbi.nlm.nih.gov/11425530
https://pubmed.ncbi.nlm.nih.gov/11425530
Autor:
Adrian J. Folkes, Khatereh Ahmadi, Wendy K. Alderton, Sonia Alix, Stewart J. Baker, Gary Box, Irina S. Chuckowree, Paul A. Clarke, Paul Depledge, Suzanne A. Eccles, Lori S. Friedman, Angela Hayes, Timothy C. Hancox, Arumugam Kugendradas, Letitia Lensun, Pauline Moore, Alan G. Olivero, Jodie Pang, Sonal Patel, Giles H. Pergl-Wilson
Publikováno v:
Journal of Medicinal Chemistry; Aug2008, Vol. 51 Issue 18, p5522-5532, 11p