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Association of Kidney-Related Safety Events with Incident Chronic Kidney Disease in Veterans

Autor: Stewart Pm, Siddiqui T, Helman, Fink Jc, Weiner S

Publikováno v: Austin Journal of Nephrology and Hypertension. 8

Objective: The impact of Nonsteroidal Anti-Inflammatory Drugs (NSAID) and iodine-based contrast exposures on developing Chronic Kidney Disease (CKD) is controversial. We examined the association of these exposures with the development of CKD in a Vet

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::6eedfa0e499896cae14d0edf4a5e3a8d
https://doi.org/10.26420/austinjnephrolhypertens.2021.1095

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Improved Urinary Cortisol Metabolome in Addison Disease : A Prospective Trial of Dual-Release Hydrocortisone

Autor: Espiard, S, McQueen, J, Sherlock, M, Ragnarsson, O, Bergthorsdottir, R, Burman, P, Dahlqvist, P, Ekman, B, Engström, BE, Skrtic, S, Wahlberg, J, Stewart, PM, Johannsson, G

CONTEXT: Oral once-daily dual-release hydrocortisone (DR-HC) replacement therapy has demonstrated an improved metabolic profile compared to conventional 3-times-daily (TID-HC) therapy among patients with primary adrenal insufficiency. This effect mig

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=dedup_wf_001::eabbbd95675fef9128765b4f0c8cba71
http://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-174794

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11βHSD1 Inhibition with AZD4017 Improves Lipid Profiles and Lean Muscle Mass in Idiopathic Intracranial Hypertension

Autor: Hardy, RS, Botfield, H, Markey, K, Mitchell, JL, Alimajstorovic, Z, Westgate, CSJ, Sagmeister, M, Fairclough, RJ, Ottridge, RS, Yiangou, A, Storbeck, K-HH, Taylor, AE, Gilligan, LC, Arlt, W, Stewart, PM, Tomlinson, JW, Mollan, SP, Lavery, GG, Sinclair, AJ

Background The enzyme 11β-hydroxysteroid dehydrogenase type 1 (11β-HSD1) determines prereceptor metabolism and activation of glucocorticoids within peripheral tissues. Its dysregulation has been implicated in a wide array of metabolic diseases, lea

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=core_ac_uk__::7a94e5b368fa7527dac8e484ff56645f

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Akademický článek

Association between premature mortality and hypopituitarism

Autor: Tomlinson, JW, Holden, N, Hills, RK, Wheatley, K, Clayton, RN, Bates, AS, Sheppard, MC, Stewart, PM

Publikováno v: In The Lancet 10 February 2001 357(9254):425-431

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11β-HSD1 modulates the set point of brown adipose tissue response to glucocorticoids in male mice

Autor: Doig, CL, Fletcher, RS, Morgan, SA, McCabe, EL, Larner, DP, Tomlinson, JW, Stewart, PM, Philp, A, Lavery, GG

Glucocorticoids (GCs) are potent regulators of energy metabolism. Chronic GC exposure suppresses brown adipose tissue (BAT) thermogenic capacity in mice, with evidence for a similar effect in humans. Intracellular GC levels are regulated by 11β-hydr

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=dedup_wf_001::37071008e10de7fafb2a938a7a74c190
https://ora.ox.ac.uk/objects/uuid:070d53df-a219-4ea5-9cd1-b8c363d4f383

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25-hydroxyvitamin D3 and 1,25-dihydroxyvitamin D3 exert distinct effects on human skeletal muscle function and gene expression

Autor: Hassan-Smith, ZK, Jenkinson, C, Smith, DJ, Hernandez, I, Morgan, SA, Crabtree, NJ, Gittoes, NJ, Keevil, BG, Stewart, PM, Hewison, M

Publikováno v: PLoS ONE
Hassan-Smith, Z K, Jenkinson, C, Smith, D J, Hernandez, I, Stuart, A M, Crabtree, N J, Gittoes, N J, Keevil, B G, Stewart, P M & Hewison, M 2017, ' 25-hydroxyvitamin D3 and 1,25-dihydroxyvitamin D3 exert distinct effects on human skeletal muscle function and gene expression ', PLoS ONE, vol. 12, no. 2, e0170665 . https://doi.org/10.1371/journal.pone.0170665
PLoS ONE, Vol 12, Iss 2, p e0170665 (2017)

Age-associated decline in muscle function represents a significant public health burden. Vitamin D-deficiency is also prevalent in aging subjects, and has been linked to loss of muscle mass and strength (sarcopenia), but the precise role of specific

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::568a7bff07d4a80dfbd5ae5324a0d15f
http://europepmc.org/articles/PMC5310904

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SFRP2 Is Associated with Increased Adiposity and VEGF Expression

Autor: Crowley, RK, O’Reilly, MW, Bujalska, IJ, Hassan-Smith, ZK, Hazlehurst, JM, Foucault, DR, Stewart, PM, Tomlinson, JW

Publikováno v: PLoS ONE
PLoS ONE, Vol 11, Iss 9, p e0163777 (2016)

Aims The aim of this study was to assess depot-specific expression and secretion of secreted frizzled-related protein 2 (sFRP2) by adipose tissue and its effect on adipocyte biology. We measured serum sFRP2 concentrations in 106 patients in vivo to e

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::cdfc63cb264599f124b673ac8cbf7004
http://europepmc.org/articles/PMC5042473

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