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Molecular basis of USP7 inhibition by selective small-molecule inhibitors.

Autor: Turnbull AP; CRUK Therapeutic Discovery Laboratories, London Bioscience Innovation Centre, London NW1 0NH, UK., Ioannidis S; FORMA Therapeutics, Arsenal Street, Watertown, Massachusetts 02472, USA., Krajewski WW; CRUK Therapeutic Discovery Laboratories, London Bioscience Innovation Centre, London NW1 0NH, UK., Pinto-Fernandez A; Target Discovery Institute, Nuffield Department of Medicine, University of Oxford, Roosevelt Drive, Oxford OX3 7FZ, UK., Heride C; Cellular and Molecular Physiology, Institute of Translational Medicine, University of Liverpool, Crown Street, Liverpool L69 3BX, UK., Martin ACL; CRUK Therapeutic Discovery Laboratories, Jonas Webb Building, Babraham Research Campus, Cambridge CB22 3AT, UK., Tonkin LM; CRUK Therapeutic Discovery Laboratories, Jonas Webb Building, Babraham Research Campus, Cambridge CB22 3AT, UK., Townsend EC; FORMA Therapeutics, Arsenal Street, Watertown, Massachusetts 02472, USA., Buker SM; FORMA Therapeutics, Arsenal Street, Watertown, Massachusetts 02472, USA., Lancia DR; FORMA Therapeutics, Arsenal Street, Watertown, Massachusetts 02472, USA., Caravella JA; FORMA Therapeutics, Arsenal Street, Watertown, Massachusetts 02472, USA., Toms AV; FORMA Therapeutics, Arsenal Street, Watertown, Massachusetts 02472, USA., Charlton TM; Target Discovery Institute, Nuffield Department of Medicine, University of Oxford, Roosevelt Drive, Oxford OX3 7FZ, UK., Lahdenranta J; FORMA Therapeutics, Arsenal Street, Watertown, Massachusetts 02472, USA., Wilker E; FORMA Therapeutics, Arsenal Street, Watertown, Massachusetts 02472, USA., Follows BC; FORMA Therapeutics, Arsenal Street, Watertown, Massachusetts 02472, USA., Evans NJ; CRUK Therapeutic Discovery Laboratories, London Bioscience Innovation Centre, London NW1 0NH, UK., Stead L; Cellular and Molecular Physiology, Institute of Translational Medicine, University of Liverpool, Crown Street, Liverpool L69 3BX, UK., Alli C; CRUK Therapeutic Discovery Laboratories, Jonas Webb Building, Babraham Research Campus, Cambridge CB22 3AT, UK., Zarayskiy VV; FORMA Therapeutics, Arsenal Street, Watertown, Massachusetts 02472, USA., Talbot AC; FORMA Therapeutics, Arsenal Street, Watertown, Massachusetts 02472, USA., Buckmelter AJ; FORMA Therapeutics, Arsenal Street, Watertown, Massachusetts 02472, USA., Wang M; FORMA Therapeutics, Arsenal Street, Watertown, Massachusetts 02472, USA., McKinnon CL; FORMA Therapeutics, Arsenal Street, Watertown, Massachusetts 02472, USA., Saab F; CRUK Therapeutic Discovery Laboratories, London Bioscience Innovation Centre, London NW1 0NH, UK., McGouran JF; Target Discovery Institute, Nuffield Department of Medicine, University of Oxford, Roosevelt Drive, Oxford OX3 7FZ, UK., Century H; Target Discovery Institute, Nuffield Department of Medicine, University of Oxford, Roosevelt Drive, Oxford OX3 7FZ, UK., Gersch M; Medical Research Council Laboratory of Molecular Biology, Francis Crick Avenue, Cambridge CB2 0QH, UK., Pittman MS; CRUK Therapeutic Discovery Laboratories, London Bioscience Innovation Centre, London NW1 0NH, UK., Marshall CG; FORMA Therapeutics, Arsenal Street, Watertown, Massachusetts 02472, USA., Raynham TM; CRUK Therapeutic Discovery Laboratories, London Bioscience Innovation Centre, London NW1 0NH, UK., Simcox M; FORMA Therapeutics, Arsenal Street, Watertown, Massachusetts 02472, USA., Stewart LMD; CRUK Therapeutic Discovery Laboratories, London Bioscience Innovation Centre, London NW1 0NH, UK., McLoughlin SB; CRUK Therapeutic Discovery Laboratories, Jonas Webb Building, Babraham Research Campus, Cambridge CB22 3AT, UK., Escobedo JA; FORMA Therapeutics, Arsenal Street, Watertown, Massachusetts 02472, USA., Bair KW; FORMA Therapeutics, Arsenal Street, Watertown, Massachusetts 02472, USA., Dinsmore CJ; FORMA Therapeutics, Arsenal Street, Watertown, Massachusetts 02472, USA., Hammonds TR; CRUK Therapeutic Discovery Laboratories, London Bioscience Innovation Centre, London NW1 0NH, UK., Kim S; FORMA Therapeutics, Arsenal Street, Watertown, Massachusetts 02472, USA., Urbé S; Cellular and Molecular Physiology, Institute of Translational Medicine, University of Liverpool, Crown Street, Liverpool L69 3BX, UK., Clague MJ; Cellular and Molecular Physiology, Institute of Translational Medicine, University of Liverpool, Crown Street, Liverpool L69 3BX, UK., Kessler BM; Target Discovery Institute, Nuffield Department of Medicine, University of Oxford, Roosevelt Drive, Oxford OX3 7FZ, UK., Komander D; Medical Research Council Laboratory of Molecular Biology, Francis Crick Avenue, Cambridge CB2 0QH, UK.

Publikováno v: Nature [Nature] 2017 Oct 26; Vol. 550 (7677), pp. 481-486. Date of Electronic Publication: 2017 Oct 18.