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Molecular insights into the surface-catalyzed secondary nucleation of amyloid-β₄₀ (Aβ₄₀) by the peptide fragment Aβ₁₆-₂₂

Autor: Bunce, SJ, Wang, Y, Stewart, KL, Ashcroft, AE, Radford, SE, Hall, CK, Wilson, AJ

Understanding the structural mechanism by which proteins and peptides aggregate is crucial given the role of fibrillar aggregates in debilitating amyloid diseases and bioinspired materials. Yet, this is a major challenge given assembly involves multi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=core_ac_uk__::355bdf0069518dc154250436e02232c4
https://eprints.whiterose.ac.uk/145685/5/eaav8216.full.pdf

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Molecular Origins of the Compatibility Between Glycosaminoglycans and Aβ40 Amyloid Fibrils

Autor: Stewart, KL, Hughes, E, Yates, EA, Middleton, DA, Radford, SE

Publikováno v: Journal of Molecular Biology

The Aβ peptide forms extracellular plaques associated with Alzheimer's disease. In addition to protein fibrils, amyloid plaques also contain non-proteinaceous components, including glycosaminoglycans (GAGs). We have shown previously that the GAG low

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::6424b387383ac1b14fe68efcdc7973cc
https://eprints.whiterose.ac.uk/118820/30/1-s2.0-S0022283617303388-main.pdf

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Atomic Details of the Interactions of Glycosaminoglycans with Amyloid-β Fibrils

Autor: Stewart, KL, Hughes, E, Yates, EA, Akien, GR, Huang, TY, Lima, MA, Rudd, TR, Guerrini, M, Hung, SC, Radford, SE, Middleton, DA

The amyloid plaques associated with Alzheimer's disease (AD) comprise fibrillar amyloid-β (Aβ) peptides as well as non-protein factors including glycosaminoglycan (GAG) polysaccharides. GAGs affect the kinetics and pathway of Aβ self-assembly and

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=core_ac_uk__::e7ca3be8a6fdbe5ff33703f0dd92f10c

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Atomic Details of the Interactions of Glycosaminoglycans with Amyloid-beta Fibrils

Autor: Stewart, KL, Hughes, E, Yates, EA, Akien, GR, Huang, T-Y, Lima, MA, Rudd, TR, Guerrini, M, Hung, S-C, Radford, SE, Middleton, DA

Publikováno v: JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

The amyloid plaques associated with Alzheimer’s disease (AD) comprise fibrillar amyloid-β (Aβ) peptides as well as non-protein factors including glycosaminoglycan (GAG) polysaccharides. GAGs affect the kinetics and pathway of Aβ self-assembly an

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=core_ac_uk__::806da6b49a713b35e42dab4f3230440d
http://livrepository.liverpool.ac.uk/3003617/1/JACS_2016.pdf

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