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pro vyhledávání: '"Stevenson V Tran"'
Autor:
Haohui Duan, Stevenson V Tran, Dávid Szüts, Adam J. Bass, Anita Giobbie-Hurder, Rachel Reed, Sabina Signoretti, Rebecca B. Jennings, Joshua Rivera, Elizabeth F Cohen, David M. Livingston, Roderick T. Bronson, Zoltan Szallasi, Miklos Diossy, Ye He, Christian Bowman-Colin, Shailja Pathania, Jesse Novak
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America
Significance Although germline heterozygous BRCA1 mutations predispose human carriers to cancer, heterozygous mouse BRCA1 mutations do not. We find that exposure to a source of upper gastrointestinal replication stress (RS) elicited a marked cancer i
Publikováno v:
Cancer Research. 80:B36-B36
Women with mutations in breast cancer (BrCa) gene BRCA1 are highly predisposed to BrCa. In these families, cancer develops almost exclusively in females and often at very young ages. The molecular pathogenic steps, especially the earliest ones that d