Zobrazeno 1 - 10
of 39
pro vyhledávání: '"Stevenson Flemer"'
Autor:
Jane T. Jones, Xi Qian, Jos L.J. van der Velden, Shi Biao Chia, David H. McMillan, Stevenson Flemer, Sidra M. Hoffman, Karolyn G. Lahue, Robert W. Schneider, James D. Nolin, Vikas Anathy, Albert van der Vliet, Danyelle M. Townsend, Kenneth D. Tew, Yvonne M.W. Janssen-Heininger
Publikováno v:
Redox Biology, Vol 8, Iss C, Pp 375-382 (2016)
Nuclear Factor kappa B (NF-κB) is a transcription factor family critical in the activation of pro- inflammatory responses. The NF-κB pathway is regulated by oxidant-induced post-translational modifications. Protein S-glutathionylation, or the conju
Externí odkaz:
https://doaj.org/article/3ed60b5204d4422aa9edd41130e7d3f4
Autor:
Stevenson Flemer Jr.
Publikováno v:
Molecules, Vol 16, Iss 4, Pp 3232-3251 (2011)
The appearance of selenium in organic synthesis is relatively rare, and thus examples in the literature pertaining to the masking of its considerable reactivity are similarly uncommon. Greene's Protecting Groups in Organic Synthesis, the standard ref
Externí odkaz:
https://doaj.org/article/522900daa4ad49068a294fe582af250b
Publikováno v:
Organic Letters. 19:4010-4013
Isothioureas tethered to bridged-bicyclic tertiary allylic amines can be converted to carbodiimides through reaction with Hg(II) salts. Intramolecular cyclization of the tethered tertiary allylic amines to the carbodiimides afford zwitterionic interm
Autor:
Danyelle M. Townsend, Yvonne M. W. Janssen-Heininger, Albert van der Vliet, Jos van der Velden, Jane T. Jones, Xi Qian, Kenneth D. Tew, Shi Biao Chia, James D. Nolin, Sidra M. Hoffman, Robert W. Schneider, Stevenson Flemer, Vikas Anathy, Karolyn G. Lahue, David H. McMillan
Publikováno v:
Redox Biology, Vol 8, Iss C, Pp 375-382 (2016)
Redox Biology
Redox Biology
Nuclear Factor kappa B (NF-κB) is a transcription factor family critical in the activation of pro- inflammatory responses. The NF-κB pathway is regulated by oxidant-induced post-translational modifications. Protein S-glutathionylation, or the conju
Autor:
Stevenson Flemer
Publikováno v:
Journal of Peptide Science. 21:53-59
We report here the synthesis of the first selenocysteine SPPS derivatives which bear TFA-labile sidechain protecting groups. New compounds Fmoc-Sec(Xan)-OH and Fmoc-Sec(Trt)-OH are presented as useful and practical alternatives to the traditional Fmo
Autor:
Stevenson Flemer
Publikováno v:
Protein & Peptide Letters. 21:1257-1264
A proof-of-principle methodology is presented in which all commercially-available cysteine (Cys) and selenocysteine (Sec) solid phase peptide synthesis (SPPS) derivatives are synthesized in high yield from easily prepared protected dichalcogenide pre
Autor:
David H, McMillan, Jos Lj, van der Velden, Karolyn G, Lahue, Xi, Qian, Robert W, Schneider, Martina S, Iberg, James D, Nolin, Sarah, Abdalla, Dylan T, Casey, Kenneth D, Tew, Danyelle M, Townsend, Colin J, Henderson, C Roland, Wolf, Kelly J, Butnor, Douglas J, Taatjes, Ralph C, Budd, Charles G, Irvin, Albert, van der Vliet, Stevenson, Flemer, Vikas, Anathy, Yvonne Mw, Janssen-Heininger
Publikováno v:
JCI insight. 1(8)
Idiopathic pulmonary fibrosis (IPF) is a debilitating lung disease characterized by excessive collagen production and fibrogenesis. Apoptosis in lung epithelial cells is critical in IPF pathogenesis, as heightened loss of these cells promotes fibrobl
Publikováno v:
Journal of Peptide Science. 18:155-162
In contrast to the large number of sidechain protecting groups available for cysteine derivatives in solid phase peptide synthesis, there is a striking paucity of analogous selenocysteine Se-protecting groups in the literature. However, the growing i
Publikováno v:
Journal of Peptide Science. 18:1-9
Of all the commercially available amino acid derivatives for solid phase peptide synthesis, none has a greater abundance of side-chain protection diversity than cysteine. The high reactivity of the cysteine thiol necessitates its attenuation during p
Publikováno v:
Journal of Peptide Science. 18:30-36
A methodology is presented for the facile synthesis of Arg-containing peptides modified at the guanidine headgroup as substituted amidine cores. This process allows for the iterative construction of these Arg isosteres while the peptide is being buil