Zobrazeno 1 - 5
of 5
pro vyhledávání: '"Steven Y Yap"'
Autor:
Tammaryn Lashley, Kerstin Sander, Nick C. Fox, Steven Y Yap, Michael Schöll, Barbara Frias, Erik Årstad, Melissa C. Wren
Publikováno v:
Brain
A next generation of tau PET tracers for the imaging of Alzheimer’s disease and other dementias has recently been developed. Whilst the new compounds have now entered clinical studies, there is limited information available to assess their suitabil
Autor:
Richard J. Spears, Alina Chrzastek, Steven Y. Yap, Kersti Karu, Abil E. Aliev, James R. Baker, Vijay Chudasama
Publikováno v:
Chemical communications (Cambridge, England). 58(35)
Herein we report a fundamental discovery on the use of tris(dialkylamino)phosphine reagents for peptide and protein modification. We discovered that C-terminal thiophosphonium species, which are uniquely stable, could be selectively and rapidly gener
Autor:
Steven Y. Yap, Huguette Savoie, Stephen J. Archibald, Ross W. Boyle, Isaline Renard, Saul Michue-Seijas, Harry C. Sample, Graeme J. Stasiuk, Benjamin P. Burke
Publikováno v:
Chemical Communications. 56:11090-11093
The goal of “personalised” medicine has seen a growing interest in the development of theranostic agents. Bifunctional, and targeted-trifunctional, theranostic water-soluble porphyrins with a histidine-like chelating group have been synthesised v
Autor:
Steven Y. Yap, Huguette Savoie, Aline Nonat, Ross W. Boyle, Thomas W. Price, Graeme J. Stasiuk, Raphaël Gillet, Loïc J. Charbonnière
Publikováno v:
Chemistry-A European Journal
Chemistry-A European Journal, Wiley-VCH Verlag, 2020, ⟨10.1002/chem.201905776⟩
Price, T, Yap, S, Gillet, R, Savoie, H, Charbonnière, L, Boyle, R, Nonat, A & Stasiuk, G J 2020, ' Evaluation of a bispidine-based chelator for gallium-68 and of the porphyrin conjugate as PET/PDT theranostic agent ', Chemistry (Weinheim an der Bergstrasse, Germany), vol. 26, no. 34, pp. 7602-7608 . https://doi.org/10.1002/chem.201905776
Chemistry-A European Journal, Wiley-VCH Verlag, 2020, ⟨10.1002/chem.201905776⟩
Price, T, Yap, S, Gillet, R, Savoie, H, Charbonnière, L, Boyle, R, Nonat, A & Stasiuk, G J 2020, ' Evaluation of a bispidine-based chelator for gallium-68 and of the porphyrin conjugate as PET/PDT theranostic agent ', Chemistry (Weinheim an der Bergstrasse, Germany), vol. 26, no. 34, pp. 7602-7608 . https://doi.org/10.1002/chem.201905776
International audience; In this study a bispidine ligand has been applied to the complexation of gallium(III) and radiolabelled with gallium-68 for the first time. Despite its 5-coordinate nature, the resulting complex is stable in serum for over two
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f172f6532dfcec3b5b59a162ea78dd0c
https://hal.archives-ouvertes.fr/hal-02870103
https://hal.archives-ouvertes.fr/hal-02870103
Publikováno v:
Chemical Communications. 54:7952-7954
A theranostic conjugate for use as a positron emission tomography (PET) radiotracer and as a photosensitiser for photodynamic therapy (PDT) has been synthesised. A water-soluble porphyrin was coupled with the bifunctional chelate, H4Dpaa.ga. This con