Zobrazeno 1 - 10
of 104
pro vyhledávání: '"Steven Y Qian"'
Autor:
Zhiguo Zhao, Lael Reinstatler, Zachary Klaassen, Yi Xu, Xiaoyu Yang, Rabii Madi, Martha K Terris, Steven Y Qian, Uddhav Kelavkar, Kelvin A Moses
Publikováno v:
PLoS ONE, Vol 11, Iss 11, p e0166594 (2016)
Epidemiological data suggest that omega-6 (ω-6) fatty acids (FAs) may be associated with cancer incidence and/or cancer mortality, whereas ω-3 FAs are potentially protective. We examined the association of the ratio of ω-6 to ω-3 FA (ω-6:ω-3) a
Externí odkaz:
https://doaj.org/article/1ea43aacd1604759ab37a05968e52da6
Autor:
Chengwei He, Xiying Qu, Jianbo Wan, Rong Rong, Lili Huang, Chun Cai, Keyuan Zhou, Yan Gu, Steven Y Qian, Jing X Kang
Publikováno v:
PLoS ONE, Vol 7, Iss 10, p e47567 (2012)
Recent studies have shown that a tumor-supportive microenvironment is characterized by high levels of pro-inflammatory and pro-angiogenic eicosanoids derived from omega-6 (n-6) arachidonic acid (AA). Although the metabolic pathways (COX, LOX, and P45
Externí odkaz:
https://doaj.org/article/61980e44f977430db3078b1e905cc24c
Publikováno v:
Molecular Therapy: Nucleic Acids, Vol 22, Iss , Pp 222-235 (2020)
Knocking down delta-5-desaturase (D5D) expression by D5D small interfering RNA (siRNA) has been reported that could redirect the cyclooxygenase-2 (COX-2)-catalyzed dihomo-γ-linolenic acid (DGLA) peroxidation from producing prostaglandin E2 to 8-hydr
Externí odkaz:
https://doaj.org/article/a6e26193aa3640e99d722ec2e98e7807
Publikováno v:
Redox Biology, Vol 11, Iss , Pp 653-662 (2017)
We recently reported that knockdown of delta-5-desaturase (a key enzyme that converts dihomo-γ-linolenic acid, DGLA, to the downstream ω-6 arachidonic acid) promotes formation of an anti-cancer byproduct 8-hydroxyoctanoic acid from cyclooxygenase (
Externí odkaz:
https://doaj.org/article/e3733639fd3947fbbda7b5163cceffd8
Supplemental Figures 1-9 with Figure Legends
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::076417a2ca4c61b421ecc50fd3811dc8
https://doi.org/10.1158/1535-7163.22503577.v1
https://doi.org/10.1158/1535-7163.22503577.v1
Publikováno v:
Free Radic Biol Med
Cyclooxygenase-2 (COX-2) is up-regulated by redox imbalance and is considered a target for cancer therapy. The rationale of the COX-2 inhibitor lies in suppressing COX-2 catalyzed peroxidation of omega-6 polyunsaturated fatty acids (PUFAs), which are
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1a89ffdbda0c911f684eeda4de623e5c
https://doi.org/10.1016/j.freeradbiomed.2021.06.004
https://doi.org/10.1016/j.freeradbiomed.2021.06.004
Autor:
Yi Xu, Steven Y. Qian
Publikováno v:
Biomedical Journal, Vol 37, Iss 3, Pp 112-119 (2014)
The ω-3 and ω-6 polyunsaturated fatty acids (PUFAs) are two major families of PUFAs present as essential cellular components which possess diverse bioactivities. The ω-3s, mainly found in seafood, are associated with many beneficial effects on hum
Externí odkaz:
https://doaj.org/article/7d5d581305e945d59fb598d54ad1af74
Publikováno v:
ACS Applied Bio Materials. 3:6865-6875
Three mononuclear or dinuclear bis(terpyridine) (tpy) iridium(III) complexes bearing pyren-1-yl (pyr) group(s) were synthesized. Their photophysical properties in water and in vitro photodynamic therapy (PDT) effects toward the human lung epithelial
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7e5f5a1eb01e132c2014419d18f195be
https://doi.org/10.1021/acsabm.0c00784
https://doi.org/10.1021/acsabm.0c00784
Publikováno v:
Translational Oncology, Vol 14, Iss 11, Pp 101207-(2021)
Translational Oncology
Translational Oncology
Highlights • D5D is an independent prognostic factor in cancer. • D5D aggravates cancer progression via mediating AA/PGE2 production from DGLA. • AA/PGE2 promotes cancer progression via regulating the tumor microenvironment. • Inhibition of D
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c81cba5e09eeffe1477f02b7b3cd5fa8
http://www.sciencedirect.com/science/article/pii/S1936523321001996
http://www.sciencedirect.com/science/article/pii/S1936523321001996
Publikováno v:
npj Breast Cancer, Vol 7, Iss 1, Pp 1-13 (2021)
NPJ Breast Cancer
NPJ Breast Cancer
Knocking down delta-5-desaturase (D5D) by siRNA or shRNA is a promising strategy to achieve 8-hydroxyoctanoic acid (8-HOA) production for cancer inhibition. However, the RNAi-based strategy to stimulate 8-HOA is restricted due to endonucleases mediat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d906aadcd431e186cd12dadde9185774
https://doi.org/10.1038/s41523-021-00330-9
https://doi.org/10.1038/s41523-021-00330-9