Výsledky vyhledávání - "Steven X. Hu"

Stability of Ketoprofen Methylester in Plasma of Different Species

Autor: Kenneth L. Feenstra, Kelsey Ernst, Charles P. Benner, Steven X. Hu

Publikováno v: Current Drug Metabolism. 22:215-223

Background: Pharmacokinetic and pharmacodynamic assessment of ester-containing drugs can be impacted by hydrolysis of the drugs in plasma samples post blood collection. The impact is different in the plasma of different species. Objective: This study

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b5b666f47ba084f03b73b825275065be
https://doi.org/10.2174/1389200221666201217141025

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Assessment of Inhibition of Bovine Hepatic Cytochrome P450 by 43 Commercial Bovine Medicines Using a Combination ofIn VitroAssays and Pharmacokinetic Data from the Literature

Autor: Kenneth L. Feenstra, Chase A. Mazur, Steven X. Hu

Publikováno v: Drug Metabolism Letters. 13:123-131

Background:There has been a lack of information about the inhibition of bovine medicines on bovine hepatic CYP450 at their commercial doses and dosing routes.Objective:The aim of this work was to assess the inhibition of 43 bovine medicines on bovine

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::7ca321dbac5d6018c9c159b38b2d3d8f
https://doi.org/10.2174/1872312813666191120094649

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Hepatic Flavin-containing Monooxygenase and Aldehyde Oxidase Activities in Male Domestic Pigs at Different Ages

Autor: Steven X. Hu

Publikováno v: Drug Metabolism Letters. 12:125-131

BACKGROUND Age has a significant impact on activities of hepatic metabolizing enzymes in humans and animals. Flavin-containing Monooxygenase (FMO) and Aldehyde Oxidase (AO) are two important hepatic enzymes. Understanding of the impact of age on thes

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cc2a6c0cc94bce8b8c14ac27826138f9
https://doi.org/10.2174/1872312812666180913145334

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Assessment of Inhibition of Bovine Hepatic Cytochrome P450 by 43 Commercial Bovine Medicines Using a Combination of

Autor: Steven X, Hu, Chase A, Mazur, Kenneth L, Feenstra

Publikováno v: Drug metabolism letters. 13(2)

There has been a lack of information about the inhibition of bovine medicines on bovine hepatic CYP450 at their commercial doses and dosing routes.The aim of this work was to assess the inhibition of 43 bovine medicines on bovine hepatic CYP450 using

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::81bc1a5c1deba9da192657d379547232
https://pubmed.ncbi.nlm.nih.gov/31750810

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Pharmacokinetics and brain distribution of amitraz and its metabolites in rats

Autor: Charles P. Benner, Kenneth L. Feenstra, Steven X. Hu, Julie A. White, Roger A. Martin

Publikováno v: Environmental toxicology and pharmacology. 65

Amitraz is an acaricide and insecticide widely used in agriculture and veterinary medicine. Although central nervous system (CNS) toxicity is one of major toxicities following oral ingestion of amitraz, the understanding of the cause of the toxicity

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::178dad294cdb846b00446cec97f67a24
https://pubmed.ncbi.nlm.nih.gov/30503806

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Development of an in vitro screen for compound bioaccumulation in Haemonchus contortus

Autor: Debra J. Woods, Xin Zhou, David P. Thompson, Alan A. Marchiondo, Christopher S. Knauer, Matthew J. Zaya, Steven X. Hu, Julie K. Lorenz, Wendy Collard, Bernard D Hummel, Dawn A. Merritt, Jinxia Nancy Deng

Publikováno v: The Journal of parasitology. 100(6)

The objective of the current study was to establish an in vitro screen and a highly sensitive analytical assay to delineate key physicochemical properties that favor compound bioaccumulation in the L3 life stage of a Haemonchus contortus isolate. Tim

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::116b2400eea8841a60fb0d2ab2dd7969
https://pubmed.ncbi.nlm.nih.gov/25116000

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Metabolism and pharmacokinetics of a novel Src kinase inhibitor TG100435 ([7-(2,6-dichloro-phenyl)-5-methyl-benzo[1,2,4]triazin-3-yl]-[4-(2-pyrrolidin-1-yl-ethoxy)-phenyl]-amine) and its active N-oxide metabolite TG100855 ([7-(2,6-dichloro-phenyl)-5-methylbenzo[1,2,4]triazin-3-yl]-{4-[2-(1-oxy-pyrrolidin-1-yl)-ethoxy]-phenyl}-amine)

Autor: Steven X, Hu, Richard, Soll, Shiyin, Yee, Daniel L, Lohse, Ahmed, Kousba, Binqi, Zeng, Xiyun, Yu, Andrew, McPherson, Joel, Renick, Jianguo, Cao, Arek, Tabak, John, Hood, John, Doukas, Glenn, Noronha, Michael, Martin

Publikováno v: Drug metabolism and disposition: the biological fate of chemicals. 35(6)

TG100435 ([7-(2,6-dichloro-phenyl)-5-methyl-benzo[1,2,4]triazin-3-yl]-[4-(2-pyrrolidin-1-yl-ethoxy)-phenyl]-amine) is a novel multitargeted, orally active protein tyrosine kinase inhibitor. The inhibition constants (K(i)) of TG100435 against Src, Lyn

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::8c7981b80db1a74ec1e48f4001aefc4f
https://pubmed.ncbi.nlm.nih.gov/17371799

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