Zobrazeno 1 - 10
of 21
pro vyhledávání: '"Steven X. Cho"'
Autor:
Ji-Seung Yoo, Michihito Sasaki, Steven X. Cho, Yusuke Kasuga, Baohui Zhu, Ryota Ouda, Yasuko Orba, Paul de Figueiredo, Hirofumi Sawa, Koichi S. Kobayashi
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-17 (2021)
The presentation of viral antigens to T cells via the MHC molecules is a critical component of the host response to viral infection. Here the authors suggest SARS-CoV-2 possesses the immune evasion strategy against the MHC class I pathway by targetin
Externí odkaz:
https://doaj.org/article/985ec8dc38ab4bd98cffc38c5682e3e9
Autor:
Sayuri Yoshihama, Steven X. Cho, Jason Yeung, Xuedong Pan, Gregory Lizee, Kranti Konganti, Valen E. Johnson, Koichi S. Kobayashi
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-12 (2021)
Abstract Checkpoint blockade-mediated immunotherapy is emerging as an effective treatment modality for multiple cancer types. However, cancer cells frequently evade the immune system, compromising the effectiveness of immunotherapy. It is crucial to
Externí odkaz:
https://doaj.org/article/de1241d0f963406ab60cbcf3271651f4
Autor:
Elys A. Green, Steven P. Garrick, Briana Peterson, Philip J. Berger, Robert Galinsky, Rod W. Hunt, Steven X. Cho, Jane E. Bourke, Marcel F. Nold, Claudia A. Nold-Petry
Publikováno v:
International Journal of Molecular Sciences, Vol 24, Iss 3, p 2795 (2023)
Preterm birth is a major contributor to neonatal morbidity and mortality. Complications of prematurity such as bronchopulmonary dysplasia (BPD, affecting the lung), pulmonary hypertension associated with BPD (BPD-PH, heart), white matter injury (WMI,
Externí odkaz:
https://doaj.org/article/385138401cc346378560e4dd652fe312
Autor:
Steven X. Cho, Ina Rudloff, Jason C. Lao, Merrin A. Pang, Rimma Goldberg, Christine B. Bui, Catriona A. McLean, Magdalena Stock, Tilman E. Klassert, Hortense Slevogt, Niamh E. Mangan, Wei Cheng, Doris Fischer, Stefan Gfroerer, Manjeet K. Sandhu, Devi Ngo, Alexander Bujotzek, Laurent Lariviere, Felix Schumacher, Georg Tiefenthaler, Friederike Beker, Clare Collins, C. Omar F. Kamlin, Kai König, Atul Malhotra, Kenneth Tan, Christiane Theda, Alex Veldman, Andrew M. Ellisdon, James C. Whisstock, Philip J. Berger, Claudia A. Nold-Petry, Marcel F. Nold
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-19 (2020)
Necrotizing Enterocolitis (NEC) is an untreatable intestinal disease in infants. Here the authors show that human and experimental mouse NEC is associated with altered toll-like receptor expression in the intestine, enhanced Th17/type 3 polarization
Externí odkaz:
https://doaj.org/article/242592c0bc1c49d49d4bb66a63310f56
Autor:
Christine B. Bui, Magdalena Kolodziej, Emma Lamanna, Kirstin Elgass, Arvind Sehgal, Ina Rudloff, Daryl O. Schwenke, Hirotsugu Tsuchimochi, Maurice A. G. M. Kroon, Steven X. Cho, Anton Maksimenko, Marian Cholewa, Philip J. Berger, Morag J. Young, Jane E. Bourke, James T. Pearson, Marcel F. Nold, Claudia A. Nold-Petry
Publikováno v:
Frontiers in Immunology, Vol 10 (2019)
Pulmonary hypertension secondary to bronchopulmonary dysplasia (BPD-PH) represents a major complication of BPD in extremely preterm infants for which there are currently no safe and effective interventions. The abundance of interleukin-1 (IL-1) is st
Externí odkaz:
https://doaj.org/article/4cf373f5de034ebeae37df5fe137e7df
Autor:
Jason C. Lao, Christine B. Bui, Merrin A. Pang, Steven X. Cho, Ina Rudloff, Kirstin Elgass, Jan Schröder, Anton Maksimenko, Niamh E. Mangan, Malcolm R. Starkey, Elisabeth M. Skuza, Yu B. Y. Sun, Friederike Beker, Clare L. Collins, Omar F. Kamlin, Kai König, Atul Malhotra, Kenneth Tan, Christiane Theda, Morag J. Young, Catriona A. McLean, Nicholas J. Wilson, Arvind Sehgal, Philip M. Hansbro, James T. Pearson, Jose M. Polo, Alex Veldman, Philip J. Berger, Claudia A. Nold-Petry, Marcel F. Nold
Publikováno v:
Science translational medicine. 14(639)
Postnatal maturation of the immune system is poorly understood, as is its impact on illnesses afflicting term or preterm infants, such as bronchopulmonary dysplasia (BPD) and BPD-associated pulmonary hypertension. These are both cardiopulmonary infla
Autor:
Yusuke Kasuga, Steven X. Cho, Baohui Zhu, Hirofumi Sawa, Yasuko Orba, Michihito Sasaki, Ryota Ouda, Ji-Seung Yoo, Koichi Kobayashi, Paul de Figueiredo
Publikováno v:
Nature Communications
Nature Communications, Vol 12, Iss 1, Pp 1-17 (2021)
Nature Communications, Vol 12, Iss 1, Pp 1-17 (2021)
The MHC class I-mediated antigen presentation pathway plays a critical role in antiviral immunity. Here we show that the MHC class I pathway is targeted by SARS-CoV-2. Analysis of the gene expression profile from COVID-19 patients as well as SARS-CoV
Autor:
Laura D’Andrea, Elsa A. Marquez, Kirsten Richter, Marcel F. Nold, Franziska Regenass-Lechner, Claudia A. Nold-Petry, Wolfgang F. Richter, Sabine Schuster, Nadia S. Deen, Ina Rudloff, Georg Tiefenthaler, Laurent Lariviere, Jasmin Sydow-Andersen, Steven X. Cho, Alexander Poehler, Andrew M. Ellisdon, Xaver Reiser, Sebastian Hoepfl, Jeannette Neubauer, James C. Whisstock, Felix Schumacher, Alexander Bujotzek
Publikováno v:
Cell Chemical Biology. 29:586-596.e4
Harnessing the immunomodulatory activity of cytokines is a focus of therapies targeting inflammatory disease. The interleukin (IL)-1 superfamily contains pro-inflammatory and anti-inflammatory members that help orchestrate the immune response in adap
Autor:
Ning An, Toshiyuki Watanabe, Saptha Vijayan, Koichi Kobayashi, Ryota Ouda, Steven X. Cho, Ji-Seung Yoo
Publikováno v:
Immunology
The presentation of antigenic peptides by major histocompatibility complex (MHC) class I and class II molecules is crucial for activation of the adaptive immune system. The nucleotide-binding domain and leucine-rich repeat receptor family members CII
Autor:
Xuedong Pan, Valen E. Johnson, Jason Yeung, Sayuri Yoshihama, Koichi Kobayashi, Kranti Konganti, Steven X. Cho, Gregory Lizée
Publikováno v:
Scientific Reports
Scientific Reports, Vol 11, Iss 1, Pp 1-12 (2021)
Scientific Reports, Vol 11, Iss 1, Pp 1-12 (2021)
Checkpoint blockade-mediated immunotherapy is emerging as an effective treatment modality for multiple cancer types. However, cancer cells frequently evade the immune system, compromising the effectiveness of immunotherapy. It is crucial to develop s