Zobrazeno 1 - 10
of 52
pro vyhledávání: '"Steven Whitebread"'
Autor:
Mateusz Maciejewski, Eugen Lounkine, Steven Whitebread, Pierre Farmer, William DuMouchel, Brian K Shoichet, Laszlo Urban
Publikováno v:
eLife, Vol 6 (2017)
The Food and Drug Administration Adverse Event Reporting System (FAERS) remains the primary source for post-marketing pharmacovigilance. The system is largely un-curated, unstandardized, and lacks a method for linking drugs to the chemical structures
Externí odkaz:
https://doaj.org/article/093147f8a3444b44bec422d9105175a0
Autor:
Cindy Li, Xu Zang, Vijay Sethuraman, Xiaoyu Shen, Johanne Blais, Heinz E. Moser, Kyuto Tashiro, Ellie Growcott, Ramadevi Prathapam, Anthony Casarez, Aregahegn Yifru, Charles Vitt, David McKenney, Tsuyoshi Uehara, Patrick J Rudewicz, Fengxia Li, Hongqiu Guo, Adriana K. Jones, Louis E. Metzger, Wanben Gong, Jacob Shaul, Alun Bermingham, Taryn Cariaga, Richard Colvin, Xiaodong Lin, Dita M. Rasper, Mika Lindvall, Dazhi Tang, Vladimir Capka, Steven Whitebread, Sara Lopez, Meiliana Tjandra, Qingming Zhu, Nancy Turner, Robert Lowell Simmons, Charles R. Dean, Alex Fekete, Folkert Reck
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 28:748-755
Metallo-β-lactamases (MBLs), such as New Delhi metallo-β-lactamase (NDM-1) have spread world-wide and present a serious threat. Expression of MBLs confers resistance in Gram-negative bacteria to all classes of β-lactam antibiotics, with the except
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::82fc48314e0379bba2ac0622f8f85e46
https://doi.org/10.1016/j.bmcl.2018.01.006
https://doi.org/10.1016/j.bmcl.2018.01.006
Autor:
S. Nassir Ghaemi, Guiqing Liang, Duncan Armstrong, Hong Jin, Bryan L. Roth, Joshua Pottel, Brian K. Shoichet, Xi Ping Huang, Alexander Fekete, Laszlo Urban, Kathleen M. Giacomini, Ellen L. Berg, John J. Irwin, Steven Whitebread, Ling Zou, Hayarpi Torosyan, Katalin V. Lukacs, Barun Bhhatarai, Samuel T. Slocum, Dallas Bednarczyk
Publikováno v:
Science (New York, N.Y.), vol 369, iss 6502
Science
Science
Excipients, considered “inactive ingredients,” are a major component of formulated drugs and play key roles in their pharmacokinetics. Despite their pervasiveness, whether they are active on any targets has not been systematically explored. We co
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d09b20fb65c9cd3b8fabfaad38953262
https://pubmed.ncbi.nlm.nih.gov/32728229
https://pubmed.ncbi.nlm.nih.gov/32728229
Autor:
W. Frieauff, H.-J. Martus, John Reilly, Duncan Armstrong, Dmitri Mikhailov, Steven Whitebread, Shu Li, Laszlo Urban
Over the last decade, a number of modern in vivo and in vitro methodologies and in silico tools have been developed to investigate toxicokinetic and toxicodynamic processes of chemicals, enabling an understanding of mechanism of action at different l
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a95d45524278b53175735a6dcce408b7
https://doi.org/10.1016/b978-0-12-409547-2.12367-4
https://doi.org/10.1016/b978-0-12-409547-2.12367-4
Publikováno v:
Journal of Medicinal Chemistry. 57:3786-3802
Matched molecular pair analysis (MMPA) has become a major tool for analyzing large chemistry data sets for promising chemical transformations. However, the dependence of MMPA predictions on data constraints such as the number of pairs involved, exper
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6d1b6972adcf68c8c5da120e655ee651
https://doi.org/10.1021/jm500317a
https://doi.org/10.1021/jm500317a
Autor:
Steven Whitebread, Patrick Y. Muller, Jacques Hamon, Alexander Fekete, Mateusz Maciejewski, Laszlo Urban, Jeremy L. Jenkins, Eugen Lounkine
Publikováno v:
Toxicol. Res.. 3:433-444
Adverse drug reactions (ADRs) are associated with most drugs, often discovered late in drug development and sometimes only during extended course of clinical use. They are linked either to the therapeutic target or pathway, or could emerge as the con
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1c4f155af490b7c24accdf2a8071d19f
https://doi.org/10.1039/c4tx00077c
https://doi.org/10.1039/c4tx00077c
Autor:
Laszlo Urban, Eugen Lounkine, Brian K. Shoichet, Mateusz Maciejewski, Pierre Farmer, Steven Whitebread, DuMouchel B
The Food and Drug Administration Adverse Event Reporting System (FAERS) is the primary source for post-marketing pharmacovigilance. Though potentially highly useful, the database reflects reporting biases, stimulated reporting, and suffers from lack
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::13084913d8a79c2ac88af6f544a99ccd
Secondary pharmacology: screening and interpretation of off-target activities - focus on translation
Autor:
Alexander Fekete, Shanni Chen, Duncan Armstrong, Berengere Dumotier, Andreas Hartmann, Steven Whitebread, Laszlo Urban, Patrick Y. Muller
Publikováno v:
Drug discovery today. 21(8)
Secondary pharmacology is an essential component of drug discovery and is used extensively in the pharmaceutical industry for achieving optimal specificity of new drugs via early hazard identification and off-target mitigation. The importance of this
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::735431dfad7ea6173608249fbab82383
https://pubmed.ncbi.nlm.nih.gov/27140035
https://pubmed.ncbi.nlm.nih.gov/27140035
Autor:
Jacques Hamon, Steven Whitebread
Publikováno v:
Hit and Lead Profiling
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::42bdfc7456981549fe30c17828a46c62
https://doi.org/10.1002/9783527627448.ch12
https://doi.org/10.1002/9783527627448.ch12
Publikováno v:
Hit and Lead Profiling
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ba1f15c2a46647c389c5f074dec72600
https://doi.org/10.1002/9783527627448.ch16
https://doi.org/10.1002/9783527627448.ch16