Zobrazeno 1 - 10
of 60
pro vyhledávání: '"Steven West"'
Publikováno v:
eLife, Vol 13 (2024)
RNA polymerase II (RNAPII) transcription initiates bidirectionally at many human protein-coding genes. Sense transcription usually dominates and leads to messenger RNA production, whereas antisense transcription rapidly terminates. The basis for this
Externí odkaz:
https://doaj.org/article/2c3f24c7b7a5449b86eaae485b5c2a3b
Autor:
Benjamin H. Jenkins, Finlay Maguire, Guy Leonard, Joshua D. Eaton, Steven West, Benjamin E. Housden, David S. Milner, Thomas A. Richards
Publikováno v:
Royal Society Open Science, Vol 8, Iss 4 (2021)
Endosymbiosis was fundamental for the evolution of eukaryotic complexity. Endosymbiotic interactions can be dissected through forward- and reverse-genetic experiments, such as RNA-interference (RNAi). However, distinguishing small (s)RNA pathways in
Externí odkaz:
https://doaj.org/article/5797075f445f481589d370f2df1e2706
Publikováno v:
eLife, Vol 10 (2021)
The human genome encodes thousands of non-coding RNAs. Many of these terminate early and are then rapidly degraded, but how their transcription is restricted is poorly understood. In a screen for protein-coding gene transcriptional termination factor
Externí odkaz:
https://doaj.org/article/db3925eccb7d4d0082a7c6bf78d0e797
Autor:
Lee Davidson, Laura Francis, Ross A. Cordiner, Joshua D. Eaton, Chris Estell, Sara Macias, Javier F. Cáceres, Steven West
Publikováno v:
Cell Reports, Vol 26, Iss 10, Pp 2779-2791.e5 (2019)
Summary: Cell-based studies of human ribonucleases traditionally rely on methods that deplete proteins slowly. We engineered cells in which the 3′→5′ exoribonucleases of the exosome complex, DIS3 and EXOSC10, can be rapidly eliminated to assess
Externí odkaz:
https://doaj.org/article/d371ae4c1a99434ea1385794f47c8f8f
Autor:
Anne Hett, Steven West
Publikováno v:
PLoS ONE, Vol 9, Iss 5, p e96174 (2014)
Most human pre-mRNAs contain introns that are removed by splicing. Such a complex process needs strict control and regulation in order to prevent the expression of aberrant or unprocessed transcripts. To analyse the fate of pre-mRNAs that cannot be s
Externí odkaz:
https://doaj.org/article/bd94fa1dfb8d47bfbe2f2bdb41d668d6
Publikováno v:
Journal of Gaming & Virtual Worlds. 14:181-206
Challenge is a key gratification sought in video games, and punishment by character death is often the repercussion for poor performance, requiring players to recover or restart. But some gamers go a step further and opt into games that feature perma
Autor:
Jennifer Hecker, Anthony Janicki, Steven West, Edward T. Sherwood, Marcus W. Beck, Michael R. Wessel, Jay R. Leverone
Publikováno v:
Estuaries and Coasts. 45:17-37
The three contiguous National Estuary Programs of southwest Florida, along with partners from six coastal counties, have developed a tidal creek water quality assessment framework to help prioritize natural resource investigations across a large popu
Autor:
Joshua D. Eaton, Steven West
Publikováno v:
Trends in Genetics. 36:664-675
RNA polymerase II (Pol II) transcribes hundreds of thousands of transcription units - a reaction always brought to a close by its termination. Because Pol II transcribes multiple gene types, its termination occurs in a variety of ways, with the polym
Autor:
Mckay Steven West, Matthew M. Martin
Publikováno v:
Communication Education. 68:328-349
Instructors use humor in the classroom in numerous ways, including behaving stupidly, offering impersonations, manipulating their nonverbals, telling a story, joke, or pun, and using a costume or p...