Zobrazeno 1 - 5
of 5
pro vyhledávání: '"Steven Wayne Pedersen"'
Autor:
Christopher W. Doecke, Michael J. Martinelli, Pawlak Joseph Matthew, D. Scott Coffey, Richard D. Miller, Timothy M. Braden, Jeffrey Thomas Vicenzi, Steven Wayne Pedersen, Bruce W. Shaw, Michael E. LeTourneau, Christopher L. Meyer, Schmid Christopher Randall, and Michael A. Staszak
Publikováno v:
Organic Process Research & Development. 11:431-440
The first kilogram-scale synthesis of the PPARα agonist LY518674 (1) is described. The de novo convergent synthetic approach involved coupling of two rapidly assembled components, triazolone formation via a novel acid-promoted cyclization reaction,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0dd9fd5b6d28e178e92176fe99739e5a
https://doi.org/10.1021/op700040v
https://doi.org/10.1021/op700040v
Publikováno v:
Tetrahedron Letters. 46:7299-7302
LY544344·HCl was efficiently prepared in two steps from LY354740. The key step highlighted the in situ masking of the carboxylic acid groups as trimethylsilyl esters to facilitate an effective acylation reaction.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::009e8ebd085c254096de46caaae54002
https://doi.org/10.1016/j.tetlet.2005.08.144
https://doi.org/10.1016/j.tetlet.2005.08.144
Autor:
Rima S. Al-awar, Michael E. LeTourneau, Marcella T. Clayton, Steven Wayne Pedersen, D. Scott Coffey, James Edward Ray, Thomas A. Engler, Sushant Malhotra, John L. Grutsch, Michael John Martinelli, Joseph Matthew Pawlak, Stanley P. Kolis, Kevin A. Sullivan, Margaret M. Faul, Kelly Wayne Furness
Publikováno v:
The Journal of Organic Chemistry. 69:2967-2975
Synthesis of indolo[6,7-a]pyrrolo[3,4-c]carbazoles 1, a new class of cyclin D1/CDK4 inhibitors, by oxidation of the corresponding aryl indolylmaleimides 2, will be described. Two approaches to the synthesis of 2 were identified that required new meth
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::37eb9dd72e993b68b945c14cc7332a64
https://doi.org/10.1021/jo035606v
https://doi.org/10.1021/jo035606v
Autor:
Steven Wayne Pedersen, Yao-Chang Xu, Marvin M. Hansen, Sandra S. Keast, Godfrey Alexander Glenn, John L. Grutsch, Marcella T. Clayton, Daniel Timothy Kohlman, Andreea R. McSpadden, Jeffrey A. Ward
Publikováno v:
Synlett. :1351-1354
2-Trimethylsilyl protection of benzothiophenes and benzofurans prevents anion migration to the 2-position when lithiated species are formed. These lithiated benzothiophenes and benzofurans provide superior results in additions to piperidones. Deprote
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::00f654013a1b36edb64f1ccc153d2a6f
https://doi.org/10.1055/s-2004-825609
https://doi.org/10.1055/s-2004-825609
Publikováno v:
ChemInform. 37
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::239c550cfce2f9549de06256a305590e
https://doi.org/10.1002/chin.200606194
https://doi.org/10.1002/chin.200606194